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1. 血小板機能に対する心臓病剤の影響 effect of cardiac drugs on platelet function
2. 血管内皮機能および血栓溶解療法の基本的メカニズム vascular endothelial function and fundamental mechanisms of fibrinolysis thrombolysis

English Journal

Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D.

Liu Y1, Park JM1, Oh SJ1, Chang KH1, Lee MY2.
European journal of pharmacology.Eur J Pharmacol.2015 Aug 5;760:81-7. doi: 10.1016/j.ejphar.2015.03.084. Epub 2015 Apr 22.
AMP-activated protein kinase (AMPK) acts as a major regulator of cellular energy homeostasis. In platelets, AMPK activation stimulates endothelial nitric oxide synthase (eNOS) and its downstream signaling, and thereby inhibits platelet aggregation. In this study, a newly developed AMPK activator 3-[
PMID 25913239

Virgin olive oil, palm olein and coconut oil diets do not raise cell adhesion molecules and thrombogenicity indices in healthy Malaysian adults.

Voon PT1, Ng TK2, Lee VK2, Nesaretnam K3.
European journal of clinical nutrition.Eur J Clin Nutr.2015 Jun;69(6):712-6. doi: 10.1038/ejcn.2015.26. Epub 2015 Mar 25.
BACKGROUND/OBJECTIVES: Effects of high-protein diets that are rich in saturated fats on cell adhesion molecules, thrombogenicity and other nonlipid markers of atherosclerosis in humans have not been firmly established. We aim to investigate the effects of high-protein Malaysian diets prepared separa
PMID 25804278

Chong CR1, Liu S1, Licari G1, Heresztyn T2, Chirkov YY1, Ngo DT1, Horowitz JD3.
The American journal of medicine.Am J Med.2015 Apr;128(4):427-30. doi: 10.1016/j.amjmed.2014.11.007. Epub 2014 Nov 25.
BACKGROUND: Hyperglycemia in patients with acute coronary syndromes is associated with poor outcomes, and its rapid correction with insulin infusion has been shown to restore platelet responsiveness to nitric oxide and to suppress superoxide (O2(-)) generation. Thioredoxin-interacting protein has em
PMID 25460870

1,4-Benzoxazine-3(4H)-ones as Potent Inhibitors of Platelet Aggregation: Design, Synthesis and Structure–Activity Relations

Platelet Aggregability in Patients with Hypertension Treated with Angiotensin II Type 1 Receptor Blockers

The Mechanism by Which Flaxseed Oil Consumption Increases Bleeding Time in Patients with Type 2 Diabetes in Cape Breton, Nova Scotia, Canada is Independent of Lipoprotein(a) Concentration