抗エストロゲン薬

WordNet

not in favor of (an action or proposal etc.)
a person who is opposed (to an action or policy or practice etc.); "the antis smelled victory after a long battle"
social insect living in organized colonies; characteristically the males and fertile queen have wings during breeding season; wingless sterile females are the workers (同)emmet, pismire
a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics (同)oestrogen

PrepTutorEJDIC

《話》(特定の慣習・政策・行動などに)反対する人
『アリ』
=ain't
エストロゲン(動物の雌を発情させる卵胞ホルモン)(《英》oestrogen)
(次にくる語の発音が母音で始まるときに用いる) / (子音[h]で始まり第1音節に強勢のない語の場合はanを用いることがある.ただし,この場合は[h]を発音しない)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/03 16:21:00」(JST)

wiki en

An antiestrogen is a substance that blocks the production or utilization of estrogens,^[1] or inhibits their effects.^[2] (Estrogens are the family of hormones that promote the development and maintenance of female sex characteristics.)

Antiestrogens like tamoxifen can promote an invasive phenotype in estrogen receptor (ER)-positive breast cancer cells with deficient intercellular adhesion.

Although aromatase inhibitors could be considered antiestrogens by some definitions, they are often considered to be a distinct class.^[3] Aromatase inhibitors reduce the production of estrogen, while the term "antiestrogen" is usually reserved for agents reducing the response to estrogen.

References

^ "Definition of antiestrogen - NCI Dictionary of Cancer Terms, Definition of antiestrogen - NCI Dictionary of Cancer Terms". http://www.cancer.gov/dictionary/?CdrID=44813. ,
^ "antiestrogen" at Dorland's Medical Dictionary
^ Riggins RB, Bouton AH, Liu MC, Clarke R (2005). "Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer". Vitam. Horm. 71: 201–37. doi:10.1016/S0083-6729(05)71007-4. PMID 16112269. http://linkinghub.elsevier.com/retrieve/pii/S0083-6729(05)71007-4.

External links

[1]

This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

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UpToDate Contents

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1. 選択的エストロゲン受容体モジュレーター・受容体ダウンレギュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators and down regulators
2. HER2陰性ホルモン受容体陽性転移性乳癌への治療法：内分泌療法 treatment approach to metastatic hormone receptor positive her2 negative breast cancer endocrine therapy
3. エストロゲン・プロゲスチン避妊剤の使用に関する概要 overview of the use of estrogen progestin contraceptives
4. タモキシフェンによるホルモン療法を受ける女性の不正子宮出血と子宮の病理 abnormal uterine bleeding and uterine pathology in women on tamoxifen therapy
5. 全身性エリテマトーデス女性患者における避妊に対するアプローチ approach to contraception in women with systemic lupus erythematosus

English Journal

Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis.

Manni A, Richie JP Jr, Xu H, Washington S, Aliaga C, Cooper TK, Bruggeman R, Das A, Prokopczyk B, Calcagnotto A, Trushin N, Dickinson R, Liao J, Verderame MF, El-Bayoumy K.SourceDivision of Endocrinology, H044, Hershey Medical Center, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USA.
International journal of oncology.Int J Oncol.2011 Nov;39(5):1153-64. doi: 10.3892/ijo.2011.1133. Epub 2011 Jul 20.
Epidemiologic studies on the protective role of omega-3 fatty acids (n:3) on breast cancer prevention remain inconclusive but studies in preclinical models provide more positive outcome. However, the mechanisms accounting for the protective effect of n:3 are not defined. In the present study, conduc
PMID 21892590

Anti-estrogen therapy for breast cancer modifies the risk of subsequent cutaneous melanoma.

Huber C, Bouchardy C, Schaffar R, Neyroud-Caspar I, Vlastos G, LE Gal FA, Rapiti E, Benhamou S.Source1Clinic of Dermatology, Geneva University Hospitals.
Cancer prevention research (Philadelphia, Pa.).Cancer Prev Res (Phila).2011 Sep 20. [Epub ahead of print]
Increased risk of secondary melanoma after breast cancer has been reported. Several lines of evidence suggest that elevated estrogen levels may be implicated in melanoma etiology. Accordingly, use of anti-estrogens should be associated with decreased risk of melanoma. We compared melanoma incidence
PMID 21933913

Japanese Journal

Recombinant follicle-stimulating hormone (follitropin alfa) versus purified urinary follicle-stimulating hormone in a low-dose step-up regimen to induce ovulation in Japanese women with anti-estrogen-ineffective oligo- or anovulatory infertility : results of a single-blind Phase III study

TAKETANI Yuji,KELLY Eduardo,YOSHIMURA Yasunori,HOSHIAI Hiroshi,IRAHARA Minoru,MIZUNUMA Hideki,SAITO Hidekazu,ANDOH Kazumichi,YANAIHARA Takumi
Reproductive medicine and biology 9(2), 99-106, 2010-06-01
NAID 10027050407

Recombinant follicle-stimulating hormone (follitropin alfa) for ovulation induction in Japanese patients with anti-estrogen-ineffective oligo- or anovulatory infertility : results of a phase II dose-response study

TAKETANI Yuji,KELLY Eduardo,YOSHIMURA Yasunori,HOSHIAI Hiroshi,IRAHARA Minoru,MIZUNUMA Hideki,SAITO Hidekazu,ANDOH Kazumichi,BEBIA Zourab,YANAIHARA Takumi
Reproductive medicine and biology 9(2), 91-97, 2010-06-01
NAID 10027050391