English Journal

Taming the Reactivity of Glycosyl Iodides To Achieve Stereoselective Glycosidation.

Gervay-Hague J1.
Accounts of chemical research.Acc Chem Res.2015 Nov 2. [Epub ahead of print]
Although glycosyl iodides have been known for more than 100 years, it was not until the 21st century that their full potential began to be harnessed for complex glycoconjugate synthesis. Mechanistic studies in the late 1990s probed glycosyl iodide formation by NMR spectroscopy and revealed important
PMID 26524481

A new glycosidation method through nitrite displacement on substituted nitrobenzenes.

Alvarez-Micó X1, Calvete MJ, Hanack M, Ziegler T.
Carbohydrate research.Carbohydr Res.2007 Feb 26;342(3-4):440-7. Epub 2006 Nov 21.
Benzyl, benzoyl, and acetyl protected 1-OH and 1-SH glycoses in the glucose, glucosamine, galactose, mannose, and lactose series react with nitrobenzenes activated by one or two electron withdrawing substituents like nitro and cyano to afford the corresponding aryl glycosides in 50-100% yield. The S
PMID 17182018

Potent and specific inhibitors of mammalian phosphoribosylpyrophosphate (PRPP) synthetase.

Willis RC1, Nord LD, Fujitaki JM, Robins RK.
Advances in enzyme regulation.Adv Enzyme Regul.1989;28:167-82.
The monophosphates of the exocyclic amino ribonucleosides, 4-amino- and 4-methoxy-8-(D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine, are potent and specific inhibitors of human erythrocyte and B-lymphoblast PRPP synthetase. The inhibition by MRPP monophosphate is competitive (Ki = 35 microM with the
PMID 2560324

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