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Anisocytosis is a medical term meaning that a patient's red blood cells are of unequal size. This is commonly found in anemia and other blood conditions. False diagnostic flagging may be triggered by an elevated WBC count, agglutinated RBCs, RBC fragments, giant platelets or platelet clumps. In addition, it is a characteristic feature of bovine blood.

The red cell distribution width (RDW) is a measurement of anisocytosis^[1] and is calculated as a coefficient of variation of the distribution of RBC volumes divided by the mean corpuscular volume (MCV)

Types

Anisocytosis is identified by RDW and is classified according to the size of RBC measured by MCV. According to this, it can be divided into

Anisocytosis with microcytosis – Iron deficiency, sickle cell anemia
Anisocytosis with macrocytosis – Folate or vitamin B12 deficiency, autoimmune hemolytic anemia, cytotoxic chemotherapy, Chronic liver disease, Myelodysplastic syndrome

Increased RDW is seen in iron deficiency anemia, Thalassemia Major (Cooley's anemia), Thalassemia Intermedia and myelodysplastic syndromes

Anisocytosis with normal RBC size – Early iron, vit B12 or folate deficiency, dimorphic anemia, Sickle cell disease, chronic liver disease, Myelodysplastic syndrome^[2]

References

^ Barbara J. Bain (2006). Blood cells: a practical guide. Wiley-Blackwell. pp. 66–. ISBN 978-1-4051-4265-6. Retrieved 10 November 2010.
^ Red Cell Distribution Width (RDW) at eMedicine

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2. 平均赤血球容積 mean corpuscular volume
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English Journal

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Dani SU.SourceDepartment of Internal Medicine I and Clinical Chemistry, University of Heidelberg General Hospital, Im Neuenheimer Feld 671, 69120 Heidelberg, Germany. Electronic address: srgdani@gmail.com.
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Bee venom induced in vivo ultrastructural reactions of cells involved in the bone marrow erythropoiesis and of circulating red blood cells.

Florea A, Crăciun C.SourceDepartment of Cell and Molecular Biology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 6 Pasteur St., 400349, Cluj-Napoca, Romania.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada.Microsc Microanal.2013 Apr;19(2):393-405. doi: 10.1017/S1431927612014195. Epub 2013 Feb 4.
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NAID 110006688960