関: anileridine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/11 23:39:12」(JST)

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Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s.^[1] It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada.^[2]

Administration[edit]

As tablets or injection.^[3]

Pharmacokinetics[edit]

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.^[4] It is mostly metabolized by the liver.

References[edit]

^ US Patent 2897204
^ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Retrieved 28 July 2008.
^ "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010.
^ "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.

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English Journal

Electronic-topological study of the structure-activity relationships in a series of piperidine morphinomimetics.

Sim E, Dimoglo A, Shvets N, Ahsen V.SourceGebze Institute of Technology, POB 141, Gebze, 41400, Turkey.
Current medicinal chemistry.Curr Med Chem.2002 Aug;9(16):1537-45.
Structure-activity relationships (SAR) are studied in the series of 4,4-disubstituted piperidine morphinomimetics (42 compounds) by means of the Electronic-Topological Method (ETM). In the frameworks of this approach, its input data were taken as the results of conformational and quantum-mechanical
PMID 12171562

Anileridine-induced delirium.

Moss JH.SourceDepartment of Psychiatry, University of Toronto, Ontario, Canada.
Journal of pain and symptom management.J Pain Symptom Manage.1995 May;10(4):318-20.
Delirium is a common complication in hospitalized patients and is often associated with significant morbidity. It is important to recognize this syndrome early so that potential causes can be identified and properly managed. Although the etiology of delirium in critically or terminally ill patients
PMID 7541439

Clinical application of nebulized opioids for treatment of dyspnoea in patients with malignant disease.

Farncombe M, Chater S.SourcePalliative Care Service, Ottawa Civic Hospital, Ontario, Canada.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.Support Care Cancer.1994 May;2(3):184-7.
This article describes our experience in the clinical use of nebulized opioids for the management of dyspnoea in patients with terminal cancer by reviewing three specific patient case studies in which this treatment was found to be both safe and effective in controlling breathlessness. The patients
PMID 7518312

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リンク元	「アニレリジン」
拡張検索	「anileridine hydrochloride」

「アニレリジン」

Anileridine
Systematic (IUPAC) name
	Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	?
Legal status	Controlled (S8) (AU) ℞-only (CA) Schedule II (US)
Routes	Tablets, injection
Pharmacokinetic data
Protein binding	> 95%
Metabolism	Hepatic
Identifiers
CAS number	144-14-9
ATC code	N01AH05
PubChem	CID 8944
DrugBank	DB00913
ChemSpider	8600
UNII	71Q1A3O279
KEGG	D02941
ChEBI	CHEBI:61203
ChEMBL	CHEMBL1201347
Chemical data
Formula	C22H28N2O2
Mol. mass	352.47 g/mol
	SMILES O=C(OCC)C3(c1ccccc1)CCN(CCc2ccc(N)cc2)CC3;
	InChI InChI=1S/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3 ; Key:LKYQLAWMNBFNJT-UHFFFAOYSA-N ;
Physical data
Melt. point	83 °C (181 °F)
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