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English Journal

Two galactose-α-1,3-galactose carrying peptidases from pork kidney mediate anaphylactogenic responses in delayed meat allergy.

Hilger C1, Fischer J2, Swiontek K1, Hentges F3, Lehners C3, Eberlein B4, Morisset M3, Biedermann T4, Ollert M1,5.
Allergy.Allergy.2016 May;71(5):711-9. doi: 10.1111/all.12835. Epub 2016 Jan 27.
BACKGROUND: Serum IgE antibodies directed at galactose-α-1,3-galactose (α-Gal) are associated with a novel form of delayed anaphylaxis occurring upon consumption of red meat or innards. Pork kidney is known as the most potent trigger of this syndrome, but the culprit allergens have not yet been id
PMID 26728983

IL-33 is a mediator rather than a trigger of the acute allergic response in humans.

Fux M1, Pecaric-Petkovic T, Odermatt A, Hausmann OV, Lorentz A, Bischoff SC, Virchow JC, Dahinden CA.
Allergy.Allergy.2014 Feb;69(2):216-22. doi: 10.1111/all.12309. Epub 2013 Nov 11.
BACKGROUND: IL-33 enhances FcεRI-induced mediator release in human basophils without inducing degranulation itself. In contrast, studies in mice suggested that in the presence of high IgE levels, IL-33 triggers degranulation and anaphylaxis of similar severity as specific allergen. Consistent with
PMID 24205920

[Evaluation of safety of prophylactic use of immunoglobulins against viral hemorrhagic fevers from horse blood sera].

Khmelev AL, Borisevich IV, Chernikova NK, Makhlaĭ AA, Mikhaĭlov VV, Iakovlev AK, Podkuĭko VN, Krasnianskiĭ VP, Borisevich SV, Bondarev VP.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii.Zh Mikrobiol Epidemiol Immunobiol.2012 Nov-Dec;(6):103-6.
AIM: Evaluate safety of prophylaxis of viral hemorrhagic fevers by specific heterologous immunoglobulins.MATERIALS AND METHODS: Clinical-laboratory examination of 24 individuals after intramuscular administration of heterologous Ebola immunoglobulin was carried out. Anaphylactogenicity of the immuno
PMID 23297643

Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production : inhibition by a non-anaphylactogenic anti-IgE antibody