関: amorolfine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/04 02:43:00」(JST)

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Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.^[1]

It is a topical solution for the treatment of toenail infections. Systemic treatments may be considered more effective.^[1]

It is approved for sale over the counter in Australia and the UK (recently re-classified to over the counter status), and is approved for the treatment of toenail fungus by prescription in other countries. It is not approved for the treatment of onychomycosis in the United States or Canada, but can be ordered from there by mail from other countries.^[2]

Notes

^ ^a ^b Hywel C. Williams (2003). Evidence-Based Dermatology. Blackwell.
^ It can readily be verified that Curanail is advertised on websites such as US Amazon.com, shipped from abroad.

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1. Onychomycosis: Management
2. 皮膚糸状菌（白癬）感染症 dermatophyte tinea infections

English Journal

Efficacy of 5% amorolfine nail lacquer in Neoscytalidium dimidiatum onychomycosis.

Bunyaratavej S1, Leeyaphan C1, Rujitharanawong C1, Surawan TM1, Muanprasat C1, Matthapan L1.
The Journal of dermatological treatment.J Dermatolog Treat.2015 Nov 11:1-5. [Epub ahead of print]
BACKGROUND: Amorolfine nail lacquer was mentioned as an effective treatment for non-dermatophyte nail infection. Onychomycosis that caused by Neoscytalidium dimidiatum is considered recalcitrant onychomycosis.OBJECTIVE: This study aimed to demonstrate efficacy and treatment outcomes of amorolfine na
PMID 26471716

Resin lacquer: a cheaper alternative to amorolfine for onychomycosis?

Yong AS1.
The British journal of dermatology.Br J Dermatol.2015 Oct;173(4):888-9. doi: 10.1111/bjd.13982.
PMID 26511823

Efficacy of topical resin lacquer, amorolfine and oral terbinafine for treating toenail onychomycosis: a prospective, randomized, controlled, investigator-blinded, parallel-group clinical trial.

Auvinen T1, Tiihonen R2, Soini M2, Wangel M3, Sipponen A2, Jokinen JJ4.
The British journal of dermatology.Br J Dermatol.2015 Oct;173(4):940-8. doi: 10.1111/bjd.13934. Epub 2015 Oct 1.
BACKGROUND: Norway spruce (Picea abies) produces resin to protect against decomposition by microbial pathogens. In vitro tests have shown that spruce resin has antifungal properties against dermatophytes known to cause nearly 90% of onychomycosis in humans.OBJECTIVES: To confirm previous in vivo obs
PMID 26036329

Japanese Journal

In vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes

Microbiology and immunology 58(1), 1-8, 2014-01
NAID 40019971018

皮膚真菌症の診断と治療のガイドライン-カンジダ症

日本医真菌学会雑誌 = Japanese journal of medical mycology 50(4), 207-212, 2009-10-30
NAID 10026094530

皮膚糸状菌に対するｌｉｒａｎａｆｔａｔｅの殺菌活性

日本医真菌学会雑誌 50(1), 9-13, 2009
NAID 130002111954

「アモロルフィン」

Amorolfine
Systematic (IUPAC) name
	(±)-(2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	78613-35-1
ATC code	D01AE16 (WHO)
PubChem	CID 54260
ChemSpider	49010
UNII	AB0BHP2FH0
KEGG	D02923
ChEBI	CHEBI:599440
ChEMBL	CHEMBL489411
Chemical data
Formula	C21H35NO
Molar mass	317.509 g/mol
	SMILES O2[C@@H](CN(CC(C)Cc1ccc(cc1)C(C)(C)CC)C[C@@H]2C)C ;
	InChI InChI=1S/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16?,17-,18+ ; Key:MQHLMHIZUIDKOO-AYHJJNSGSA-N ;
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