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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/11 15:22:52」(JST)

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Amlexanox (trade name Aphthasol) is a medication with antiallergic and anti-inflammatory effects used in the treatment of aphthous ulcers (canker sores). Amlexanox is also available in Japan as oral tablets (trade name Solfa) for treatment of bronchial asthma, where it has been marketed by the Takeda Pharmaceutical Company since 1987, though Aphthtab by Egyptian Eva pharma also exist. In India it is available as Lexanox by Macleods Pharmaceuticals Ltd. In Bangladesh it is marketed by Square Pharmaceuticals as Apsol.

External links

Information about the use against aphthous ulcers
Information from Takeda
Aphthasol

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English Journal

Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns.

Halder SK, Matsunaga H, Ueda H.SourceDepartment of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Journal of neurochemistry.J Neurochem.2012 Oct;123(2):262-75. doi: 10.1111/j.1471-4159.2012.07897.x. Epub 2012 Aug 23.
Prothymosin alpha (ProTα), a nuclear protein devoid of signal sequence, has been shown to possess a number of cellular functions including cell survival. Most recently, we demonstrated that ProTα is localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocyte
PMID 22853710

Rescue of nonsense mutations by amlexanox in human cells.

Gonzalez-Hilarion S, Beghyn T, Jia J, Debreuck N, Berte G, Mamchaoui K, Mouly V, Gruenert DC, Déprez B, Lejeune F.SourceUniversité Lille Nord de France, IFR142, Lille, France. fabrice.lejeune@inserm.fr.
Orphanet journal of rare diseases.Orphanet J Rare Dis.2012 Aug 31;7:58. doi: 10.1186/1750-1172-7-58.
ABSTRACT:BACKGROUND: Nonsense mutations are at the origin of many cancers and inherited genetic diseases. The consequence of nonsense mutations is often the absence of mutant gene expression due to the activation of an mRNA surveillance mechanism called nonsense-mediated mRNA decay (NMD). Strategies
PMID 22938201

Japanese Journal

Synergistic Ca2+ and Cu2+ requirements of the FGF1-S100A13 interaction measured by quartz crystal microbalance: An initial step in amlexanox-reversible non-classical release of FGF1

Matsunaga Hayato,Ueda Hiroshi
Neurochemistry International 52(6), 1076-1085, 2008-05
… The Cu2+-induced potentiation of this interaction was abolished by amlexanox, which inhibits non-classical release of FGF1. …
NAID 120000916677

Experimental Allergic Conjunctivitis in Guinea Pigs Induced by Japanese Cedar Pollen

TAKADA Miho,YAMADA Tamao,NAKAHARA Hiroto,SUGIMOTO Yukio,IZUSHI Keiji,KAMEI Chiaki
Biological & pharmaceutical bulletin 23(5), 566-569, 2000-05-01
… Although a high concentration was needed, tranilast and amlexanox also showed significant inhibition of conjunctivitis induced by cedar pollen. …
NAID 110003640020

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Amlexanox
Systematic (IUPAC) name
	2-amino-7-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
Clinical data
Trade names	Aphthasol
AHFS/Drugs.com	monograph
MedlinePlus	a601017
Pregnancy cat.	?
Legal status	?
Routes	Topical
Pharmacokinetic data
Half-life	3.5 hours
Excretion	Renal (17%)
Identifiers
CAS number	68302-57-8
ATC code	A01AD07 R03DX01
PubChem	CID 2161
DrugBank	DB01025
ChemSpider	2076
UNII	BRL1C2459K
KEGG	D01828
ChEBI	CHEBI:31205
ChEMBL	CHEMBL1096
Chemical data
Formula	C16H14N2O4
Mol. mass	298.293 g/mol
	SMILES O=C1c3cc(ccc3Oc2nc(c(cc12)C(=O)O)N)C(C)C;
	InChI InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21) ; Key:SGRYPYWGNKJSDL-UHFFFAOYSA-N ;
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英: amlexanox
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amlexanox