アミノムコン酸セミアルデヒド脱水素酵素、アミノムコン酸セミアルデヒドデヒドロゲナーゼ
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/14 04:55:04」(JST)
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| aminomuconate-semialdehyde dehydrogenase |
| Identifiers |
| EC number |
1.2.1.32 |
| CAS number |
37250-95-6 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
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In enzymology, an aminomuconate-semialdehyde dehydrogenase (EC 1.2.1.32) is an enzyme that catalyzes the chemical reaction
- 2-aminomuconate 6-semialdehyde + NAD+ + H2O 2-aminomuconate + NADH + 2 H+
The 3 substrates of this enzyme are 2-aminomuconate 6-semialdehyde, NAD+, and H2O, whereas its 3 products are 2-aminomuconate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase. Other names in common use include 2-aminomuconate semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, and 2-hydroxymuconic semialdehyde dehydrogenase. This enzyme participates in 3 metabolic pathways: benzoic acid degradation via hydroxylation, tryptophan metabolism, and the degradation pathway for toluene and xylene.
References
- SENOH S; Nakamura, S; Kawai, H; Honjo, T; Nishizuka, Y; Hayaishi, O; Senoh, S (1965). "STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID". J. Biol. Chem. 240: 740–9. PMID 14275130.
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Metabolism: amino acid metabolism · synthesis and catabolism enzymes (essential in CAPS)
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| K→acetyl-CoA |
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LYSINE→
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- Saccharopine dehydrogenase
- Glutaryl-CoA dehydrogenase
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LEUCINE→
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- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Isovaleryl coenzyme A dehydrogenase
- Methylcrotonyl-CoA carboxylase
- Methylglutaconyl-CoA hydratase
- 3-hydroxy-3-methylglutaryl-CoA lyase
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TRYPTOPHAN→
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- Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase
- Arylformamidase
- Kynureninase
- 3-hydroxyanthranilate oxidase
- Aminocarboxymuconate-semialdehyde decarboxylase
- Aminomuconate-semialdehyde dehydrogenase
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PHENYLALANINE→tyrosine→
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(see below)
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| G |
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G→pyruvate
→citrate
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glycine→serine→
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- Serine hydroxymethyltransferase
- Serine dehydratase
- glycine→creatine: Guanidinoacetate N-methyltransferase
- Creatine kinase
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alanine→
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cysteine→
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threonine→
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- L-threonine dehydrogenase
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G→glutamate→
α-ketoglutarate
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HISTIDINE→
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- Histidine ammonia-lyase
- Urocanate hydratase
- Formiminotransferase cyclodeaminase
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proline→
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- Proline oxidase
- Pyrroline-5-carboxylate reductase
- 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1
- PYCR1
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arginine→
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- Ornithine aminotransferase
- Ornithine decarboxylase
- Agmatinase
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→alpha-ketoglutarate→TCA
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Other
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- cysteine+glutamate→glutathione: Gamma-glutamylcysteine synthetase
- Glutathione synthetase
- Gamma-glutamyl transpeptidase
- glutamate→glutamine: Glutamine synthetase
- Glutaminase
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G→propionyl-CoA→
succinyl-CoA
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VALINE→
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- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Enoyl-CoA hydratase
- 3-hydroxyisobutyryl-CoA hydrolase
- 3-hydroxyisobutyrate dehydrogenase
- Methylmalonate semialdehyde dehydrogenase
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ISOLEUCINE→
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- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
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METHIONINE→
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- generation of homocysteine: Methionine adenosyltransferase
- Adenosylhomocysteinase
- regeneration of methionine: Methionine synthase/Homocysteine methyltransferase
- Betaine-homocysteine methyltransferase
- conversion to cysteine: Cystathionine beta synthase
- Cystathionine gamma-lyase
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THREONINE→
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→succinyl-CoA→TCA
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- Propionyl-CoA carboxylase
- Methylmalonyl CoA epimerase
- Methylmalonyl-CoA mutase
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G→fumarate
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PHENYLALANINE→tyrosine→
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- Phenylalanine hydroxylase
- Tyrosine aminotransferase
- 4-Hydroxyphenylpyruvate dioxygenase
- Homogentisate 1,2-dioxygenase
- Fumarylacetoacetate hydrolase
- tyrosine→melanin: Tyrosinase
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G→oxaloacetate
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asparagine→aspartate→
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- Asparaginase/Asparagine synthetase
- Aspartate transaminase
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3.
- Takenaka S, Murakami S, Kim YJ, Aoki K.SourceDepartment of Biofunctional Chemistry, Faculty of Agriculture, Graduate School of Science and Technology, Kobe University, Rokko, Japan.
- Archives of microbiology.Arch Microbiol.2000 Oct;174(4):265-72.
- A 13.9-kb region, which contained the 2-aminophenol 1,6-dioxygenase genes (amnBA) reported before, was cloned from the 2-aminophenol-assimilating bacterium Pseudomonas sp. AP-3. The complete nucleotide sequence of this region was determined and six genes were found downstream of amnBA. The eight gen
- PMID 11081795
- Identification and characterization of the nitrobenzene catabolic plasmids pNB1 and pNB2 in Pseudomonas putida HS12.
- Park HS, Kim HS.SourceDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1, Kusung-dong, Yusong-gu, Taejon 305-701, Korea.
- Journal of bacteriology.J Bacteriol.2000 Feb;182(3):573-80.
- Pseudomonas putida HS12, which is able to grow on nitrobenzene, was found to carry two plasmids, pNB1 and pNB2. The activity assay experiments of wild-type HS12(pNB1 and pNB2), a spontaneous mutant HS121(pNB2), and a cured derivative HS124(pNB1) demonstrated that the catabolic genes coding for the n
- PMID 10633088
- Preparation of 2-aminomuconate from 2-aminophenol by coupled enzymatic dioxygenation and dehydrogenation reactions.
- He Z, Spain J.SourceAir Force Research Laboratory, Tyndall Air Force Base, Florida 32403, USA.
- Journal of industrial microbiology & biotechnology.J Ind Microbiol Biotechnol.1999 Aug;23(2):138-142.
- 2-Aminomuconate is an intermediate in the oxidative metabolism of tryptophan in mammals. The compound is not commercially available, and studies of its metabolism have been prevented by the lack of a chemical synthesis and the instability of the molecule. We report here the formation of 2-aminomucon
- PMID 10510494
Related Links
- References for "Aminomuconate-semialdehyde dehydrogenase" im Internet, an Universitäten und in der Literatur... cyclopaedia.net ... In enzymology, an aminomuconate-semialdehyde dehydrogenase (EC 1.2.1.32) is an enzyme that catalyzes ...
- The European Bioinformatics Institute ... Database Code Database Name UniProtKB Universal Protein Knowledgebase UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot UniProtKB/TrEMBL UniProtKB-TrEMBL protein sequence database
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- aminomuconate-semialdehyde dehydrogenase
- 関
- アミノムコン酸セミアルデヒドデヒドロゲナーゼ
[★]
- 英
- aminomuconate-semialdehyde dehydrogenase
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- アミノムコン酸セミアルデヒド脱水素酵素
[★]
脱水素酵素 デヒドロゲナーゼ
[★]
脱水素酵素 デヒドロゲナーゼ