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UpToDate Contents
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English Journal
- Aminoimidazole Carboxamide Ribotide Exerts Opposing Effects on Thiamine Synthesis in Salmonella enterica.
- Bazurto JV1, Heitman NJ1, Downs DM2.
- Journal of bacteriology.J Bacteriol.2015 Sep;197(17):2821-30. doi: 10.1128/JB.00282-15. Epub 2015 Jun 22.
- In Salmonella enterica, the thiamine biosynthetic intermediate 5-aminoimidazole ribotide (AIR) can be synthesized de novo independently of the early purine biosynthetic reactions. This secondary route to AIR synthesis is dependent on (i) 5-amino-4-imidazolecarboxamide ribotide (AICAR) accumulation,
- PMID 26100042
- Screening for adenylosuccinate lyase deficiency using tandem mass spectrometry analysis of succinylpurines in neonatal dried blood spots.
- Zikanova M1, Krijt J2, Skopova V3, Krijt M4, Baresova V5, Kmoch S6.
- Clinical biochemistry.Clin Biochem.2015 Jan;48(1-2):2-7. doi: 10.1016/j.clinbiochem.2014.10.004. Epub 2014 Oct 23.
- OBJECTIVES: Stable isotope dilution coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the sensitive method for screening for various inherited metabolic disorders using dried blood spots (DBSs). We present a method for LC-MS/MS determination of succinyladenosine (SAdo) and su
- PMID 25445730
- Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase.
- Al-Moujahed A1, Nicolaou F2, Brodowska K1, Papakostas TD1, Marmalidou A1, Ksander BR3, Miller JW1, Gragoudas E1, Vavvas DG1.
- Investigative ophthalmology & visual science.Invest Ophthalmol Vis Sci.2014 Apr 29;55(7):4175-85. doi: 10.1167/iovs.13-12856.
- PURPOSE: To evaluate the effects and mechanism of aminoimidazole carboxamide ribonucleotide (AICAR), an AMP-dependent kinase (AMPK) activator, on the growth of uveal melanoma cell lines.METHODS: Four different cell lines were treated with AICAR (1-4 mM). Cell growth was assessed by 3-(4,5-dimethylth
- PMID 24781943
Related Links
- Publication » 5-aminoimidazole-4-carboxamide ribotide (AICAR) and its metabolites: ... "0" : "Department of Nutrition Sciences, The University of Alabama at ... www.researchgate.net/publication/223663514_5-aminoimidazole-4 ...
- The colorimetric assay for 5-aminoimidazole-4-carboxamide ribotide (AICAR) transformylase (phosphoribosylamino-imidazolecarboxamide formyltransferase; EC 2.1.2.3) has been extensively modified. The modified assay is based ...
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