aminocyclopentane

English Journal

A novel and selective fluoride opening of aziridines by XtalFluor-E. synthesis of fluorinated diamino acid derivatives.

Nonn M1, Kiss L, Haukka M, Fustero S, Fülöp F.
Organic letters.Org Lett.2015 Mar 6;17(5):1074-7. doi: 10.1021/acs.orglett.5b00182. Epub 2015 Feb 16.
The selective introduction of fluorine onto the skeleton of an aminocyclopentane or cyclohexane carboxylate has been developed through a novel and efficient fluoride opening of an activated aziridine ring with XtalFluor-E. The reaction proceeded through a stereoselective aziridination of the olefini
PMID 25686276

Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115).

Lee H1, Doud EH, Wu R, Sanishvili R, Juncosa JI, Liu D, Kelleher NL, Silverman RB.
Journal of the American Chemical Society.J Am Chem Soc.2015 Feb 25;137(7):2628-40. doi: 10.1021/ja512299n. Epub 2015 Feb 10.
γ-Aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, the principal inhibitory neurotransmitter in mammalian cells. When the concentration of GABA falls below a threshold level, convulsions can occur. Inhibition of GABA-AT raises GABA
PMID 25616005

Improved tumor-targeting MRI contrast agents: Gd(DOTA) conjugates of a cycloalkane-based RGD peptide.

Park JA1, Lee YJ2, Ko IO2, Kim TJ3, Chang Y3, Lim SM4, Kim KM2, Kim JY5.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Dec 12;455(3-4):246-50. doi: 10.1016/j.bbrc.2014.10.155. Epub 2014 Nov 6.
Two new MRI contrast agents, Gd-DOTA-c(RGD-ACP-K) (1) and Gd-DOTA-c(RGD-ACH-K) (2), which were designed by incorporating aminocyclopentane (ACP)- or aminocyclohexane (ACH)-carboxylic acid into Gd-DOTA (gadolinium-tetraazacyclo dodecanetetraacetic acid) and cyclic RGDK peptides, were synthesized and
PMID 25449282

Ca^<2+>-Dependent Induction of Intracellular Ca^<2+> Oscillation in Hippocampal Astrocytes During Metabotropic Glutamate Receptor Activation

1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid(1S,3R-ACPD)の中脳網様体注入によって誘発されるラットのけいれん反応について

Expression of Group I Metabotropic Glutamate Receptors in Rat Hippocampal Cells in Culture and Their Characterization by Intracellular Calcium Ion Dynamics