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English Journal

Inactivation of peptidylglycine α-hydroxylating monooxygenase by cinnamic acid analogs.

McIntyre NR1, Lowe EW Jr1, Battistini MR2, Leahy JW2,3, Merkler DJ2.
Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2016 Aug;31(4):551-62. doi: 10.3109/14756366.2015.1046064. Epub 2015 May 29.
Peptidylglycine α-amidating monooxygenase (PAM) is a bifunctional enzyme that catalyzes the final reaction in the maturation of α-amidated peptide hormones. Peptidylglycine α-hydroxylating monooxygenase (PHM) is the PAM domain responsible for the copper-, ascorbate- and O2-dependent hydroxylation
PMID 26024288

Barsu N1, Rahman MA2, Sen M3, Sundararaju B4.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2016 May 11. doi: 10.1002/chem.201601597. [Epub ahead of print]
An efficient, external oxidant free, Cp*Co(III) catalyzed C(sp3)-H bond amidation of 8-methylquinoline using oxazolone as an efficient amidating agent is reported for the first time under mild conditions. The reaction is selective and tolerates variety of functional groups.Based on previous reports
PMID 27168249

Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells.

Jeffries KA1, Dempsey DR1, Farrell EK1, Anderson RL1, Garbade GJ1, Gurina TS1, Gruhonjic I1, Gunderson CA1, Merkler DJ2.
Journal of lipid research.J Lipid Res.2016 May;57(5):781-90. doi: 10.1194/jlr.M062042. Epub 2016 Mar 25.
Long-chain fatty acid amides are signaling lipids found in mammals and other organisms; however, details of the metabolic pathways for the N-acylglycines and primary fatty acid amides (PFAMs) have remained elusive. Heavy-labeled precursor and subtraction lipidomic experiments in mouse neuroblastoma
PMID 27016726

梅村一之,大谷惇,岩坂健志,吉澤孝之,山野辺輝,野田剛
科学・技術研究 7(2), 149-152, 2018
各種医薬品をはじめ生理活性物質の合成において、アミド化やエステル化反応は最も基本となる反応の一つである。著者らは、スルホニルハライドを用いた効果的なアミド化、エステル化反応を開発した。このスルホニルハライドを用いる方法は、反応試薬が安価かつ操作性に優れることから、特に大量生産が要求される領域において簡便で効果的なアミド化、エステル化方法として広く利用されることが期待される。
NAID 130007599081

Rhodium(III)-catalyzed C(sp<sup>3</sup>)–H Amidation of 8-Methylquinolines with Amides at Room Temperature

Huang Xiaolei,You Jingsong
Chemistry Letters 44(12), 1685-1687, 2015
… Here we disclose a Rh(III)-catalyzed chelation-assisted C(sp<sup>3</sup>)–H activation of 8-methylquinolines, which can enable intermolecular amidation using commercially available, reliable amides as the amidating reagent to provide an efficient route to quinolin-8-ylmethanamine derivatives. …
NAID 130005112518

Use of reversed phase HP liquid chromatography to assay conversion of N-acylglycines to primary fatty acid amides by peptidylglycine-α-amidating monooxygenase

CARPENTER Tara,POORE Derek D.,GEE Andrew J.,DESHPANDE Pallavi,MERKLER David J.,JOHNSON Mitchell E.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 809(1), 15-21, 2004-09-25
NAID 10016554986