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Benznidazole prevents endothelial damage in an experimental model of Chagas disease.

Molina-Berríos A, Campos-Estrada C, Lapier M, Duaso J, Kemmerling U, Galanti N, Leiva M, Ferreira J, López-Muñoz R, Maya JD.SourceCentro de Investigación Biomédica, Facultad de Medicina, Universidad Diego Portales, Av. Ejercito 141, Santiago, Chile.
Acta tropica.Acta Trop.2013 Jul;127(1):6-13. doi: 10.1016/j.actatropica.2013.03.006. Epub 2013 Mar 23.
OBJECTIVES: To evaluate the effect of benznidazole on endothelial activation in a murine model of Chagas disease.METHODS: A low (30mg/kg/day) and a high (100mg/kg/day) dose of benznidazole were administered to mice infected with Trypanosoma cruzi during the early phases of the infection. The effects
PMID 23529066

A Novel Leishmania major Amastigote Assay in 96-Well Format for Rapid Drug Screening and Its Use for Discovery and Evaluation of a New Class of Leishmanicidal Quinolinium Salts.

Bringmann G, Thomale K, Bischof S, Schneider C, Schultheis M, Schwarz T, Moll H, Schurigt U.SourceInstitute of Organic Chemistry, University of Würzburg, Würzburg, Germany.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Jul;57(7):3003-11. doi: 10.1128/AAC.02201-12. Epub 2013 Apr 15.
In most laboratories, the screening for leishmanicidal compounds is carried out with Leishmania promastigotes or axenic amastigotes. However, the best approach to identify leishmanicidal compounds is the use of amastigotes residing in macrophages. Reporter gene-based assays are relatively new tools
PMID 23587955

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay.

De Rycker M, Hallyburton I, Thomas J, Campbell L, Wyllie S, Joshi D, Cameron S, Gilbert IH, Wyatt PG, Frearson JA, Fairlamb AH, Gray DW.SourceDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Jul;57(7):2913-22. doi: 10.1128/AAC.02398-12. Epub 2013 Apr 9.
Visceral leishmaniasis is a neglected tropical disease with significant health impact. The current treatments are poor, and there is an urgent need to develop new drugs. Primary screening assays used for drug discovery campaigns have typically used free-living forms of the Leishmania parasite to all
PMID 23571538

Comparative in vivo expression of amastigote up regulated Leishmania genes in three different forms of Leishmaniasis

SHARMA Paresh,GURUMURTHY Srividya,DUNCAN Robert,NAKHASI Hira L.,SALOTRA Poonam
Parasitology international : official journal of the Japanese Society of Parasitology 59(2), 262-264, 2010-06-01
NAID 10029824451

Yatawara Lalani,Wickramasinghe Susiji,Jayantha Rajapakse R. P. V.,Laxman R. Siyambalagoda R. R. M.,Le Thanh Hoa,Watanabe Yoshiya,Agatsuma Takeshi
Tropical medicine and health 36(4), 171-179, 2008-12-01
… Morphology of the amastigote of the Sri Lankan isolate was checked by light microscopy and electron microscopic observation. …
NAID 10025714933

SERENO D.,DA SILVA A. Cordeiro,MATHIEU-DAUDE F.,OUAISSI A.
Parasitology international : official journal of the Japanese Society of Parasitology 56(1), 3-7, 2007-03-30
NAID 10018565944