WordNet

pertaining to the tiny air sacs of the lungs
pertaining to the sockets of the teeth or that part of the upper jaw; "alveolar processes"
a highly malignant neoplasm derived from striated muscle (同)rhabdosarcoma

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/12 19:57:41」(JST)

Alveolar rhabdomyosarcoma is a type of rhabdomyosarcoma characterized by its appearance, which is similar to the alveoli of the lungs.

It can be associated with a fusion protein between PAX3 and FKHR (now known as FOXO1).^[1]^[2]

It can also be associated with PAX7-FKHR.^[3]^[4]

^ Fredericks WJ, Galili N, Mukhopadhyay S, et al. (March 1995). "The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3". Mol. Cell. Biol. 15 (3): 1522–35. PMC 230376. PMID 7862145.
^ Mercado GE, Xia SJ, Zhang C, et al. (June 2008). "Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target". Genes Chromosomes Cancer 47 (6): 510–20. doi:10.1002/gcc.20554. PMID 18335505.
^ Mercado GE, Barr FG (February 2007). "Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: recent advances". Curr. Mol. Med. 7 (1): 47–61. doi:10.2174/156652407779940440. PMID 17311532.
^ Laé M, Ahn EH, Mercado GE, et al. (June 2007). "Global gene expression profiling of PAX-FKHR fusion-positive alveolar and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas". J. Pathol. 212 (2): 143–51. doi:10.1002/path.2170. PMID 17471488.

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Pediatric rhabdomyosarcoma at presentation: Can cross-sectional imaging findings predict pathologic tumor subtype?

Franco A, Lewis KN, Lee JR.SourceGeorgia Health Sciences University, Children's Medical Center, Department of Radiology, 1120 15th Avenue, Augusta, GA 30912, United States.
European journal of radiology.Eur J Radiol.2011 Dec;80(3):e446-50. Epub 2011 Feb 8.
OBJECTIVE: The purpose of the study is to determine whether there are cross-sectional imaging features of pediatric rhabdomyosarcoma that are specific to the different pathologic subtypes of the tumor.MATERIALS AND METHODS: Medical records of 14 pediatric patients who were diagnosed with rhabdomyosa
PMID 21306853

Soft tissue sarcoma across the age spectrum: a population-based study from the Surveillance Epidemiology and End Results database.

Ferrari A, Sultan I, Huang TT, Rodriguez-Galindo C, Shehadeh A, Meazza C, Ness KK, Casanova M, Spunt SL.SourcePediatric Oncology Unit, Istituto Nazionale Tumori, Milano, Italy.
Pediatric blood & cancer.Pediatr Blood Cancer.2011 Dec 1;57(6):943-9. doi: 10.1002/pbc.23252. Epub 2011 Jul 25.
BACKGROUND: Soft tissue sarcomas (STS) are a heterogeneous group of mesenchymal malignancies that occur throughout the lifespan. The impact of age on disease features and outcome is unclear.METHODS: We analyzed the clinical features and outcome of all STS cases registered between 1973 and 2006 in th
PMID 21793180

荒志保子,坪田大,郷充 [他],新谷朋子,才川悦子,長屋朋典,永井洋輔,関伸彦,氷見徹夫
耳鼻咽喉科臨床 104(5), 325-330, 2011-05-01
… Although the most common soft-tissue sarcoma in children, rhabdomyosarcoma (RMS) is rare in adults. … Tumor biopsy showed alveolar rhabdosarcoma. …
NAID 10027972572

Roza Marcello Rodrigues da,Amorim Rivadavio Fernandes Batista de,Carneiro Fabiana Pirani [他],BENATTO Nara,BARRIVIERA Mauricio,MIGUEL Márcia Cristina da Costa
日本獣醫學会会誌 72(10), 1363-1366, 2010
… Rhabdomyosarcoma (RMS) is a malignant neoplasm derived from mesenchymal tissue with a tendency toward myogenic differentiation associated with the embryogenesis of skeletal muscle. … According to the histological features, it can be classified in embryonal, botryoid, alveolar, and pleomorphic, which usually correspond to clinical behavior and prognosis. …
NAID 130000264213

IHARA Tatsuya,OKAMURA Daisuke,TAKAHASHI Naoki,KOHRI Mika,KAYANO Hidekazu,TAMARU Jun-ichi,NIITSU Nozomi
Journal of clinical and experimental hematopathology 48(2), 61-64, 2008-11-01
… Rhabdomyosarcoma is exceedingly rare in adults. … The patient was diagnosed as having alveolar rhabdomyosarcoma. … We conclude that rhabdomyosarcoma should be included in the differential diagnoses of CD56<SUP>+</SUP> …
NAID 10023917300