Changes in protein domains outside the catalytic site of the bacteriophage Qβ replicase reduce the mutagenic effect of 5-azacytidine.
Cabanillas L1, Sanjuán R2, Lázaro E3.
Journal of virology.J Virol.2014 Sep;88(18):10480-7. doi: 10.1128/JVI.00979-14. Epub 2014 Jun 25.
The high genetic heterogeneity and great adaptability of RNA viruses are ultimately caused by the low replication fidelity of their polymerases. However, single amino acid substitutions that modify replication fidelity can evolve in response to mutagenic treatments with nucleoside analogues. Here, w
Heparin is a sulfated glycosaminoglycan that is widely used as an anticoagulant. It is typically extracted from porcine or bovine sources to yield a heterogeneous mixture that varies both in molecular weight and in degree of sulfation. This heterogeneity, coupled with concern for contamination, has
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Jun 15;192(12):5499-508. doi: 10.4049/jimmunol.1400065. Epub 2014 May 12.
Extensive studies have been undertaken to describe naive B cells differentiating into memory B cells at a cellular and molecular level. However, relatively little is known about the fate of memory B cells upon Ag re-encounter. We have previously established a system based on virus-like particles (VL
"Allolevivirus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are ... A bacteriophage genus of the family LEVIVIRIDAE, whose viruses contain the ...