Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis.
Guariento AH1, Furtado KS, de Conti A, Campos A, Purgatto E, Carrilho J, Shinohara EM, Tryndyak V, Han T, Fuscoe JC, Ross SA, Beland FA, Pogribny IP, Moreno FS.
International journal of cancer. Journal international du cancer.Int J Cancer.2014 Jul 1;135(1):7-18. doi: 10.1002/ijc.28642. Epub 2014 Feb 22.
The steady increase in the incidence and mortality of hepatocellular carcinoma (HCC) signifies a crucial need to understand better its pathogenesis to improve clinical management and prevention of the disease. The aim of this study was to investigate molecular mechanisms for the chemopreventive effe
Investigations on the Effect of O6-Benzylguanine on the Formation of dG-dC Interstrand Cross-Links Induced by Chloroethylnitrosoureas in Human Glioma Cells Using Stable Isotope Dilution High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry.
Sun G1, Zhao L, Fan T, Li S, Zhong R.
Chemical research in toxicology.Chem Res Toxicol.2014 Jun 17. [Epub ahead of print]
Chloroethylnitrosoureas (CENUs) are bifunctional alkylating agents widely used for the clinical treatment of cancer. They exert anticancer activity by inducing DNA interstrand cross-links (ICLs) within GC base pairs to form dG-dC cross-links. This lesion inhibits DNA double strand separation during
Glutathione-dependent One-electron Transfer Reactions Catalyzed by a B12 Trafficking Protein.
Li Z1, Gherasim C1, Lesniak NA1, Banerjee R2.
The Journal of biological chemistry.J Biol Chem.2014 Jun 6;289(23):16487-16497. Epub 2014 Apr 17.
CblC is involved in an early step in cytoplasmic cobalamin processing following entry of the cofactor into the cytoplasm. CblC converts the cobalamin cargo arriving from the lysosome to a common cob(II)alamin intermediate, which can be subsequently converted to the biologically active forms. Human C
Alkyltransferase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Alkyltransferase Description of Alkyltransferase Alkyltransferase: EC 2.5 ...
Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine. Biochem J. 2000 Apr 15; 347(Pt 2):527-34. [Biochem J. 2000] Alteration of the conserved residue ...