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English Journal

Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents.

Armand L1,2, Tarantini A1,2, Beal D1,2, Biola-Clier M1,2, Bobyk L1,2, Sorieul S3, Pernet-Gallay K4,5, Marie-Desvergne C6, Lynch I7, Herlin-Boime N8, Carriere M1,2.
Nanotoxicology.Nanotoxicology.2016 Sep;10(7):913-23. doi: 10.3109/17435390.2016.1141338. Epub 2016 Feb 22.
Titanium dioxide nanoparticles (TiO2-NPs) are one of the most produced NPs in the world. Their toxicity has been studied for a decade using acute exposure scenarios, i.e. high exposure concentrations and short exposure times. In the present study, we evaluated their genotoxic impact using long-term
PMID 26785166

Low Anti-Müllerian Hormone in Pediatric Cancer Survivors in the Early Years after Gonadotoxic Therapy.

Elchuri SV1, Patterson BC2, Brown M3, Bedient C4, Record E5, Wasilewski-Masker K5, Mertens AC5, Meacham LR2.
Journal of pediatric and adolescent gynecology.J Pediatr Adolesc Gynecol.2016 Aug;29(4):393-9. doi: 10.1016/j.jpag.2016.02.009. Epub 2016 Feb 26.
STUDY OBJECTIVE: To obtain anti-Müllerian hormone (AMH) levels in female childhood cancer survivors and determine the association of therapeutic exposures with diminished ovarian reserve (DOR).DESIGN: Cross-sectional study.SETTING: Academic medical center.PARTICIPANTS: Forty-nine survivors (mean ag
PMID 26924632

Wohlman IM1, Composto GM1, Heck DE2, Heindel ND3, Lacey CJ3, Guillon CD3, Casillas RP4, Croutch CR4, Gerecke DR1, Laskin DL1, Joseph LB1, Laskin JD5.
Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2016 Jul 15;303:30-44. doi: 10.1016/j.taap.2016.04.014. Epub 2016 Apr 26.
Vesicants including sulfur mustard (SM) and nitrogen mustard (NM) are bifunctional alkylating agents that cause skin inflammation, edema and blistering. This is associated with alterations in keratinocyte growth and differentiation. Endogenous cannabinoids, including N-arachidonoylethanolamine (anan
PMID 27125198

Alkylator-Induced DNA Excision Repair in Human Leukemia CCRF-CEM Cells In Vitro, Measured Using the Single-Cell Gel Electrophoresis (Comet) Assay

YAMAUCHI Takahiro,KAWAI Yasukazu,UEDA Takanori
International journal of hematology 76(4), 328-332, 2002-11-01
The capacity to repair DNA damage is an important factor that affects the therapeutic outcome in cancer treatment. To clarify the cellular repair response, we investigated the kinetics of DNA excision …
NAID 10010314457

DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine.

Yamauchi Takahiro,Nowak Billie J.,Keating Michael J.,Plunkett William
Clinical cancer research : an official journal of the American Association for Cancer Research 7(11), 3580-3589, 2001-11
… Because incorporation of nucleotide analogues into the repair patches elicits death signals in quiescent cells, the increased capacity for excision repair in alkylator-resistant cells could facilitate incorporation of nucleotide analogues. …
NAID 120000807640