aldosterone receptor

• アルドステロン受容体、アルドステロンレセプター

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
2. a corticosteroid hormone that is secreted by the cortex of the adrenal gland; regulates salt (sodium and potassium) and water balance

PrepTutorEJDIC

1. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/18 21:36:55」(JST)

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Nuclear receptor subfamily 3, group C, member 2
PDB rendering based on 1gdc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Y9R, 1YA3, 2A3I, 2AA2, 2AA5, 2AA6, 2AA7, 2AAX, 2AB2, 2ABI, 2OAX, 3VHU, 3VHV
Identifiers
Symbols	NR3C2; MCR; MLR; MR; NR3C2VIT
External IDs	OMIM: 600983 MGI: 99459 HomoloGene: 121495 IUPHAR: NR3C2 ChEMBL: 1994 GeneCards: NR3C2 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • steroid hormone receptor activity • steroid binding • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular component • nucleoplasm • endoplasmic reticulum membrane Biological process • transcription initiation from RNA polymerase II promoter • signal transduction • gene expression Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4306	110784
Ensembl	ENSG00000151623	ENSMUSG00000031618
UniProt	P08235	Q8VII8
RefSeq (mRNA)	NM_000901.4	NM_001083906.1
RefSeq (protein)	NP_000892.2	NP_001077375.1
Location (UCSC)	Chr 4: 149 – 149.37 Mb	Chr 8: 76.9 – 77.25 Mb
PubMed search	[1]	[2]

The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.

MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus.

Function

MR is expressed in many tissues, such as the kidney, colon, heart, central nervous system (hippocampus), brown adipose tissue and sweat glands. In epithelial tissues, its activation leads to the expression of proteins regulating ionic and water transports (mainly the epithelial sodium channel or ENaC, Na+/K+ pump, serum and glucocorticoid induced kinase or SGK1) resulting in the reabsoprtion of sodium, and as a consequence an increase in extracellular volume, increase in blood pressure, and an excretion of potassium to maintain a normal salt concentration in the body.

The receptor is activated by mineralocorticoids such as aldosterone and deoxycorticosterone as well as glucocorticoids, like cortisol. In intact animals, the mineralocorticoid receptor is "protected" from glucocorticoids by co-localization of an enzyme, Corticosteroid 11-beta-dehydrogenase isozyme 2 (aka 11-β-hydroxysteroid dehydrogenase 2; 11ß-HSD2), that converts cortisol to inactive cortisone. It also responds to some progestins. Spironolactone and eplerenone are mineralocorticoid receptor antagonists.

Activation of the mineralocorticoid receptor, upon the binding of its ligand aldosterone, results in its translocation to the cell nucleus, homodimerization and binding to hormone response elements present in the promoter of some genes. This results in the complex recruitment of the transcriptional machinery and the transcription into mRNA of the DNA sequence of the activated genes.

Interactions

Mineralocorticoid receptor has been shown to interact with:

• Glucocorticoid receptor and
• TRIM24.

References

Further reading

• Hellal-Levy C, Fagart J, Souque A, Rafestin-Oblin ME (2000). "Mechanistic aspects of mineralocorticoid receptor activation.". Kidney Int. 57 (4): 1250–5. doi:10.1046/j.1523-1755.2000.00958.x. PMID 10760050.
• Sheppard KE (2002). "Nuclear receptors. II. Intestinal corticosteroid receptors.". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (5): G742–6. doi:10.1152/ajpgi.00531.2001. PMID 11960770.
• Kjellander CG (1975). "[The psychotherapeutic society--utopia or nightmare?]". Lakartidningen 72 (12): 1160–1. PMID 1134129.
• Alnemri ES, Maksymowych AB, Robertson NM, Litwack G (1991). "Overexpression and characterization of the human mineralocorticoid receptor.". J. Biol. Chem. 266 (27): 18072–81. PMID 1655735.
• Morrison N, Harrap SB, Arriza JL, et al. (1990). "Regional chromosomal assignment of the human mineralocorticoid receptor gene to 4q31.1.". Hum. Genet. 85 (1): 130–2. doi:10.1007/BF00276340. PMID 2162806.
• Fan YS, Eddy RL, Byers MG, et al. (1990). "The human mineralocorticoid receptor gene (MLR) is located on chromosome 4 at q31.2.". Cytogenet. Cell Genet. 52 (1-2): 83–4. doi:10.1159/000132846. PMID 2558856.
• Arriza JL, Weinberger C, Cerelli G, et al. (1987). "Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.". Science 237 (4812): 268–75. doi:10.1126/science.3037703. PMID 3037703.
• Bloem LJ, Guo C, Pratt JH (1996). "Identification of a splice variant of the rat and human mineralocorticoid receptor genes.". J. Steroid Biochem. Mol. Biol. 55 (2): 159–62. doi:10.1016/0960-0760(95)00162-S. PMID 7495694.
• Jalaguier S, Mornet D, Mesnier D, et al. (1996). "Human mineralocorticoid receptor interacts with actin under mineralocorticoid ligand modulation.". FEBS Lett. 384 (2): 112–6. doi:10.1016/0014-5793(96)00295-5. PMID 8612804.
• Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.". J. Biol. Chem. 272 (18): 12062–8. doi:10.1074/jbc.272.18.12062. PMID 9115274.
• Zennaro MC, Farman N, Bonvalet JP, Lombès M (1997). "Tissue-specific expression of alpha and beta messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states.". J. Clin. Endocrinol. Metab. 82 (5): 1345–52. doi:10.1210/jc.82.5.1345. PMID 9141514.
• Bruner KL, Derfoul A, Robertson NM, et al. (1998). "The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52.". Receptors & signal transduction 7 (2): 85–98. PMID 9392437.
• Geller DS, Rodriguez-Soriano J, Vallo Boado A, et al. (1998). "Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I.". Nat. Genet. 19 (3): 279–81. doi:10.1038/966. PMID 9662404.
• Lupo B, Mesnier D, Auzou G (1998). "Cysteines 849 and 942 of human mineralocorticoid receptor are crucial for steroid binding.". Biochemistry 37 (35): 12153–9. doi:10.1021/bi980593e. PMID 9724527.
• Halushka MK, Fan JB, Bentley K, et al. (1999). "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.". Nat. Genet. 22 (3): 239–47. doi:10.1038/10297. PMID 10391210.
• Freeman BC, Felts SJ, Toft DO, Yamamoto KR (2000). "The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies.". Genes Dev. 14 (4): 422–34. PMC 316379. PMID 10691735. //www.ncbi.nlm.nih.gov/pmc/articles/PMC316379/.
• Geller DS, Farhi A, Pinkerton N, et al. (2000). "Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy.". Science 289 (5476): 119–23. doi:10.1126/science.289.5476.119. PMID 10884226.
• Hellal-Levy C, Fagart J, Souque A, et al. (2001). "Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor.". Mol. Endocrinol. 14 (8): 1210–21. doi:10.1210/me.14.8.1210. PMID 10935545.
• Watzka M, Beyenburg S, Blümcke I, et al. (2000). "Expression of mineralocorticoid and glucocorticoid receptor mRNA in the human hippocampus.". Neurosci. Lett. 290 (2): 121–4. doi:10.1016/S0304-3940(00)01325-2. PMID 10936692.

External links

• Mineralocorticoid+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

• Low-dose neonatal domoic acid causes persistent changes in behavioural and molecular indicators of stress response in rats.

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• Behavioural brain research.Behav Brain Res.2012 May 1;230(2):409-17. Epub 2012 Mar 1.
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• PMID 22387806

• Importance of stress receptor-mediated mechanisms in the amygdala on visceral pain perception in an intrinsically anxious rat.

• Johnson AC, Tran L, Schulkin J, Meerveld BG.SourceOklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA Department of Research, American College of Obstetricians and Gynecologists, Washington DC, USA V.A. Medical Center, Oklahoma City, OK, USA Department of Physiology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
• Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.Neurogastroenterol Motil.2012 May;24(5):479-86. doi: 10.1111/j.1365-2982.2012.01899.x. Epub 2012 Feb 26.
• Background  Stress worsens abdominal pain experienced by patients with irritable bowel syndrome (IBS), a chronic disorder of unknown origin with comorbid anxiety. Previously, we have demonstrated colonic hypersensitivity in Wistar-Kyoto rats (WKYs), a high-anxiety strain, which models abdominal pa
• PMID 22364507

Japanese Journal

• A Study on the Occurrence and Prevention of Perioperative Stroke after Coronary Artery Bypass Grafting

• , , , , , , , , , , , , , ,
• Annals of Thoracic and Cardiovascular Surgery advpub(0), 2015
• … The risk factors for postoperative atrial fibrillation were 75 or higher years of age, chronic kidney diseases, emergency surgery, cardiopulmonary bypass time >180 min, intraoperative carperitide non-use, intraoperative landiolol hydrochloride non-use, preoperative angiotensin II receptor blockers (ARB) non-use, preoperative calcium antagonist use, preoperative statin use, postoperative β-blocker non-use, and postoperative aldosterone blocker non-use. …
• NAID 130005074678

• 脳RAA系と認知機能 (特集 生活習慣病と認知機能 : 認知症の予防を見据えた生活習慣病の治療を目指して) -- (基礎知見)

• 堀内 正嗣
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• 羽森 貫,根本 慎太郎,佐々木 智康,勝間田 敬弘,岸 勘太,奥村 謙一,尾崎 智康,片山 博視
• 日本小児循環器学会雑誌 30(4), 438-447, 2014
• … 圧症の病態の本質は肺動脈リモデリングである．しかし，肺高血圧症におけるaldosterone系のリモデリングへの関与は明らかでない．本研究ではmonocrotaline誘発肺高血圧ラットを用い，肺動脈リモデリングにおけるaldosterone系の関与を検討した．加えてmonocrotaline投与の翌日からの選択的mineralocorticoid receptor拮抗薬（eplerenone）による治療介入を行い，病態形成への有効性を比較・評価 …
• NAID 130004684473

Related Links

• Aldosterone receptor | Fundstellen im Internet | cyclopaedia.net

Der Begriff Aldosterone receptor ist im englisch-sprachigen Wikipedia aufgeführt. Dort heißt es dazu: The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group ...

• Aldosterone receptor antagonists

What they do Aldosterone receptor antagonists block the effects of a hormones produced naturally by your adrenal glands which can cause your heart failure to get worse. Aldosterone receptor antagonists affect the balance of water ...

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aldosterone receptor

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アルドステロンレセプター

「アルドステロンレセプター」

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英

aldosterone receptor

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アルドステロン受容体