aldose-ketose isomerase

アルドース・ケトース異性化酵素

WordNet

1. a monosaccharide sugar that contains the aldehyde group or is hemiacetal
2. any monosaccharide sugar that contains a ketone group or its hemiacetal
3. an enzyme that catalyzes its substrate to an isomeric form

UpToDate Contents

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• 1. 糖尿病合併症の予防におけるアルドース還元酵素阻害剤 aldose reductase inhibitors in the prevention of diabetic complications
• 2. 糖尿病性神経障害の治療 treatment of diabetic neuropathy
• 3. リウマチ性血管炎の臨床症状および診断 clinical manifestations and diagnosis of rheumatoid vasculitis
• 4. 関節リウマチの病因 pathogenesis of rheumatoid arthritis
• 5. Chapter 4C：細胞容積の維持 chapter 4c maintenance of cell volume

English Journal

• Grease matrix as a versatile carrier of proteins for serial crystallography.

• Sugahara M1, Mizohata E2, Nango E1, Suzuki M3, Tanaka T1, Masuda T4, Tanaka R1, Shimamura T5, Tanaka Y5, Suno C5, Ihara K5, Pan D6, Kakinouchi K7, Sugiyama S7, Murata M7, Inoue T2, Tono K8, Song C1, Park J1, Kameshima T8, Hatsui T1, Joti Y8, Yabashi M1, Iwata S9.
• Nature methods.Nat Methods.2015 Jan;12(1):61-3. doi: 10.1038/nmeth.3172. Epub 2014 Nov 10.
• Serial femtosecond X-ray crystallography (SFX) has revolutionized atomic-resolution structural investigation by expanding applicability to micrometer-sized protein crystals, even at room temperature, and by enabling dynamics studies. However, reliable crystal-carrying media for SFX are lacking. Here
• PMID 25384243

• Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.

• Masini T1, Hirsch AK.
• Journal of medicinal chemistry.J Med Chem.2014 Dec 11;57(23):9740-63. doi: 10.1021/jm5010978. Epub 2014 Sep 25.
• Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2C-methyl-D-erythritol 4-phosphate (MEP, 5) pathway for the biosynthesis of isopentenyl diphosphate (1) and dimethylallyl diphosph
• PMID 25210872

• Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC.

• Konzuch S1, Umeda T, Held J, Hähn S, Brücher K, Lienau C, Behrendt CT, Gräwert T, Bacher A, Illarionov B, Fischer M, Mordmüller B, Tanaka N, Kurz T.
• Journal of medicinal chemistry.J Med Chem.2014 Nov 13;57(21):8827-38. doi: 10.1021/jm500850y. Epub 2014 Oct 20.
• 1-Deoxy-d-xylulose 5-phosphate reductoisomerase of Plasmodium falciparum (PfIspC, PfDxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid biosynthesis (MEP pathway), is a clinically validated antimalarial target. The enzyme is efficiently inhibited by the natural p
• PMID 25254502

Japanese Journal

• Enzymatic Characterization of 5-Methylthioribose 1-Phosphate Isomerase from Bacillus subtilis

• Saito Yohtaro,Ashida Hiroki,Kojima Chojiro [他],TAMURA Haruka,MATSUMURA Hiroyoshi,KAI Yasushi,YOKOTA Akiho
• Bioscience, biotechnology, and biochemistry 71(8), 2021-2028, 2007-08-23
• … The catalysis of MtnA is a novel isomerization of an aldose phosphate harboring a phosphate group on the hemiacetal group. … The isomerase reaction analyzed using the recombinant <I>B. … The equilibrium constant in the reversible isomerase reaction [MTRu-1-P]/[MTR-1-P] was 6. …
• NAID 10027517927

Related Links

• LSDシソーラス: アルドース・ケトース異性化酵素 Aldose-Ketose ...

英語をクリック → Aldose-Ketose Isomerase との組み合わせでEntrez を検索 異性化酵素 (Isomerase); グルコサミン (Glucosamine); アミノ酸配列 (Amino Acid Sequence); 代謝 (Metabolism); 無胞子グラム陽性桿菌 (Gram-Positive ); (); ...

• Mechanism for aldose-ketose interconversion by D-xylose ...

1. J Mol Biol. 1990 Mar 5;212(1):211-35. Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift. Collyer CA, Henrick K, Blow DM. The active site and mechanism of D ...

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「アルドース・ケトース異性化酵素」

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英

aldose-ketose isomerase