English Journal

A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats - implications for treating complex partial seizures.

Taha AY, Trepanier MO, Ciobanu FA, Taha NM, Ahmed M, Zeng Q, Cheuk WI, Ip B, Filo E, Scott BW, Burnham WM, Bazinet RP.SourceDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada M5S 1A8; University of Toronto Epilepsy Research Program, Toronto, ON, Canada M5S 1A8. Electronic address: a.taha@utoronto.ca.
Epilepsy & behavior : E&B.Epilepsy Behav.2013 Apr;27(1):49-58. doi: 10.1016/j.yebeh.2012.12.004. Epub 2013 Jan 31.
Complex partial seizures, which typically originate in limbic structures such as the amygdala, are often resistant to antiseizure medications. Our goal was to investigate the effects of chronic dietary supplementation with n-3 polyunsaturated fatty acids (PUFAs) derived from fish oil on seizure thre
PMID 23376336

Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats.

Srivastava AK, White HS.SourceAnticonvulsant Drug Development (ADD) Program, Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, USA.
Epilepsy research.Epilepsy Res.2013 Mar;104(1-2):26-34. doi: 10.1016/j.eplepsyres.2012.10.003. Epub 2012 Nov 14.
The voltage gated sodium channel (VGSC) blocker lamotrigine (LTG), when administered during kindling acquisition, leads to the development of resistance to LTG. The present study aimed to assess whether LTG-resistant amygdala-kindled rats display subsequent resistance to the VGSC blocker carbamazepi
PMID 23158096

Changes on D2-like receptor induced Gi protein activation and hippocampal dopamine release in kindled rats.

Alcantara-Gonzalez D, Floran B, Escartin E, Rocha L.SourceDepartment of Pharmacobiology, Center for Research and Advanced Studies, Mexico City, Mexico.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2013 Jan 10;40:246-51. doi: 10.1016/j.pnpbp.2012.10.007. Epub 2012 Oct 18.
The present study aimed to characterize dopamine release in the hippocampus and D2-like receptor-induced Gi protein activation in several brain areas of fully kindled rats. During the interictal period, kindled rats showed lower extracellular levels of dopamine when compared with those obtained in t
PMID 23085386

Japanese Journal

水口真理,落合亜貴子,党雅子,日谷明裕,相良博典,春木宏介
Dokkyo journal of medical sciences 40(2), 79-85, 2013-07-25
医療ケア関連肺炎(HCAP)は,ATS/IDSAの肺炎のガイドライン(2005年)にて提唱された概念である.当院におけるHCAPの特徴を明らかにする目的で前向き研究を行った.2010年1〜12月に獨協医科大学越谷病院呼吸器内科に市中肺炎で入院した患者を対象とした.HCAPと市中肺炎(CAP)の判断にあたっては, HCAP疑い因子の有無をアンケートにより調査した.それ以外の介入は行わず,背景因子,肺 …
NAID 110009606243

Identification of QTLs Involved in the Development of Amygdala Kindling in the Rat

Hashimoto Ryoko,Voigt Birger,Ishimaru Yuji,Hokao Ryoji,Chiba Shigeru,Serikawa Tadao,Sasa Masashi,Kuramoto Takashi
Experimental Animals 62(3), 181-187, 2013
… They included the afterdischarge threshold (ADT), the afterdischarge duration (ADD), and the kindling rate, an incidence of development of kindling. …
NAID 130003362956

高瀬敬一郎,重藤寛史,鎌田崇嗣 [他],Ohyagi Yasumasa,Kira Jun-ichi,高瀬敬一郎,重藤寛史,鎌田崇嗣,大八木保政,吉良潤一,タカセケイイチロウ,シゲトウヒロシ,カマダタカシ,オオヤギヤスマサ,キラジュンイチ
福岡医学雑誌 100(8), 274-280, 2009-08-25
… Afterdischarge thresholds and durations were measured at each frequency. … Seizure behaviors were not different among the groups and there were no statistically significant differences in the cortical afterdischarge (AD) thresholds between animals with MD stimulations and controls in all frequencies. …
NAID 120001672650