アデニロコハク酸
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/13 14:44:47」(JST)
[Wiki en表示]
| Adenylosuccinate |
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| Identifiers |
| CAS number |
19240-42-7 Y |
| PubChem |
195 |
| ChemSpider |
389122 Y |
| MeSH |
Adenylosuccinate |
| ChEBI |
CHEBI:15919 Y |
| Jmol-3D images |
Image 1 |
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O=C(O)CC(C(=O)O)Nc3ncnc1c3ncn1[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)COP(=O)(O)O
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InChI=1S/C14H18N5O11P/c20-7(21)1-5(14(24)25)18-11-8-12(16-3-15-11)19(4-17-8)13-10(23)9(22)6(30-13)2-29-31(26,27)28/h3-6,9-10,13,22-23H,1-2H2,(H,20,21)(H,24,25)(H,15,16,18)(H2,26,27,28)/t5?,6-,9-,10-,13-/m1/s1 Y
Key: OFBHPPMPBOJXRT-DPXQIYNJSA-N Y
InChI=1/C14H18N5O11P/c20-7(21)1-5(14(24)25)18-11-8-12(16-3-15-11)19(4-17-8)13-10(23)9(22)6(30-13)2-29-31(26,27)28/h3-6,9-10,13,22-23H,1-2H2,(H,20,21)(H,24,25)(H,15,16,18)(H2,26,27,28)/t5?,6-,9-,10-,13-/m1/s1
Key: OFBHPPMPBOJXRT-DPXQIYNJBG
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| Properties |
| Molecular formula |
C14H18N5O11P |
| Molar mass |
463.294 g/mol |
Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
| Infobox references |
Adenylosuccinate is an intermediate in the interconversion of purine nucleotides inosine monophosphate (IMP) and adenosine monophosphate (AMP). The enzyme adenylosuccinate synthase carries out the reaction by the addition of aspartate to IMP and requires the input of energy from a phosphoanhydride bond in the form of guanosine triphosphate (GTP).[1] GTP is used instead of adenosine triphosphate (ATP), so the reaction is not dependent on its products.
See also
- Adenylosuccinate lyase deficiency
- Purine nucleotide cycle
References
- ^ Figures 20.4 and 20.7 in Textbook of Biochemistry, with clinical correlations, Sixth Edition, Thomas M. Devlin, Ed., Wiley-Liss, Inc., New York, NY, 2006
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Nucleotide metabolic intermediates
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| Purine metabolism |
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Anabolism
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R5P→IMP: R5P · PRPP · PRA · GAR · FGAR · FGAM · AIR · CAIR · SAICAR · AICAR · FAICAR
IMP→AMP: Adenylosuccinate
IMP→GMP: Xanthosine monophosphate
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Catabolism
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Hypoxanthine · Xanthine · Uric acid · 5-Hydroxyisourate
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| Pyrimidine metabolism |
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Anabolism
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Carbamoyl phosphate · Carbamoyl aspartic acid · 4,5-Dihydroorotic acid · Orotic acid · Orotidine 5'-monophosphate · Uridine monophosphate
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Catabolism
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uracil: Dihydrouracil · 3-Ureidopropionic acid · β-Alanine
thymine: Dihydrothymine · β-Ureidoisobutyric acid · 3-Aminoisobutyric acid
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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- biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- amino acids / intermediates
- tetrapyrroles / intermediates
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UpToDate Contents
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English Journal
- Selection of an efficient promoter and its application in toyocamycin production improvement in Streptomyces diastatochromogenes 1628.
- Xu X1, Wang J1, Bechthold A2, Ma Z3, Yu X4.
- World journal of microbiology & biotechnology.World J Microbiol Biotechnol.2017 Feb;33(2):30. doi: 10.1007/s11274-016-2194-1. Epub 2017 Jan 5.
- The selection of efficient promoter is usually very crucial for gene expression and metabolic engineering in Streptomycetes. In this study, the synthetic promoters SPL-57and SPL-21, and the engineered promoter kasOp*were selected and their activities were examined by using a reporter gene assay base
- PMID 28058639
- CRISPR-Cas9 induced mutations along de novo purine synthesis in HeLa cells result in accumulation of individual enzyme substrates and affect purinosome formation.
- Baresova V1, Krijt M1, Skopova V1, Souckova O1, Kmoch S1, Zikanova M2.
- Molecular genetics and metabolism.Mol Genet Metab.2016 Nov;119(3):270-277. doi: 10.1016/j.ymgme.2016.08.004. Epub 2016 Aug 24.
- Purines are essential molecules for nucleic acid synthesis and are the most common carriers of chemical energy in all living organisms. The cellular pool of purines is maintained by the balance between their de novo synthesis (DNPS), recycling and degradation. DNPS includes ten reactions catalysed b
- PMID 27590927
- The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease.
- Chen P1, Wang D1, Chen H1, Zhou Z1, He X2.
- Genome research.Genome Res.2016 Oct;26(10):1355-1362. Epub 2016 Jul 20.
- Essential genes refer to those whose null mutation leads to lethality or sterility. Theoretical reasoning and empirical data both suggest that the fatal effect of inactivating an essential gene can be attributed to either the loss of indispensable core cellular function (Type I), or the gain of fata
- PMID 27440870
Japanese Journal
- Differentially expressed proteins in fluconazole-susceptible and fluconazole-resistant isolates of <i>Candida glabrata </i>
- Uptake of AMP, ADP, and ATP in Escherichia coli W
- Bioscience, biotechnology, and biochemistry 75(1), 7-12, 2011-01-23
- NAID 10027896383
- Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency
Related Links
- 1. J Inherit Metab Dis. 2015 Mar;38(2):231-42. doi: 10.1007/s10545-014-9755-y. Epub 2014 Aug 12. Adenylosuccinate lyase deficiency. Jurecka A(1), Zikanova M, Kmoch S, Tylki-Szymańska A. Author information: (1 ...
- Adenylosuccinate lyase deficiency is a neurological disorder that causes brain dysfunction (encephalopathy) leading to delayed development of mental and movement abilities (psychomotor delay), autistic behaviors that affect ...
- 世界最大級の抗体製品数を取り扱うNovus Biologicals社のAdenylosuccinate Lyaseに対する抗体(anti-Adenylosuccinate Lyase | antibody Adenylosuccinate Lyase)です。Novus Biologicals社の抗体は数多くの学術論文で使用実績があり ...
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アデニロコハク酸合成酵素、アデニロコハク酸シンターゼ
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アデニロコハク酸リアーゼ