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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/24 00:38:05」(JST)
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| Warthin's tumor |
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This Warthin's tumor presented as a parotid mass in a middle-aged male, who underwent superficial parotidectomy. The tumor, at the right of the image, is well-demarcated from the adjacent parotid tissue and tends to shell out from it.
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| Classification and external resources |
| ICD-10 |
D11 |
| ICD-9 |
210.2 |
| ICD-O |
8561/0 |
| DiseasesDB |
31941 |
| eMedicine |
plastic/371 |
| MeSH |
D000235 |
- Not to be confused with Wharton's duct (submandibular duct)
Warthin's tumor or Warthin tumour, also known as papillary cystadenoma lymphomatosum, monomorphic adenoma or adenolymphoma, is a benign cystic tumor of the salivary glands containing abundant lymphocytes and germinal centers (lymph node-like stroma). It is named for pathologist Aldred Scott Warthin, who described two cases in 1929.[1]
Contents
- 1 Etiology
- 2 Locations
- 3 Characteristic
- 4 Histology
- 5 Treatment
- 6 Additional images
- 7 See also
- 8 References
- 9 Additional sources
- 10 External links
Etiology
Its etiology is unknown, but there is a strong association with cigarette smoking. Smokers are at 8 times greater risk of developing Warthin's tumor than the general population.[2]
Locations
The gland most likely affected is the parotid gland. In fact, it is the only tumor virtually restricted to the parotid gland. Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor.
Characteristic
Low magnification micrograph of a
Warthin tumor arising from the parotid gland.
Warthin's tumor primarily affects older individuals (age 60–70 years). There is a slight female predilection according to recent studies, but historically it has been associated with a strong male predilection. This change is possibly due to the tumor's association with cigarette smoking and the growing use of cigarettes by women. The tumor is slow growing, painless, and usually appears in the tail of the parotid gland near the angle of the mandible. In 5–14% of cases, Warthin's tumor is bilateral, but the two masses usually are at different times. Warthin's tumor is highly unlikely to become malignant.
Histology
The appearance of this tumor under the microscope is unique. There are cystic spaces surrounded by two uniform rows of cells with centrally placed pyknotic nuclei. The cystic spaces have epithelium referred to as papillary infoldings that protrude into them. Additionally, the epithelium has lymphoid stroma with germinal center formation.
The differential diagnosis includes sebaceous lymphadenoma and oncocytoma.
Treatment
Most of these tumors are treated with surgical removal. It is non recurrent .
Additional images
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Histopathology of Warthin tumor in the parotid gland. H&E stain.
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Histopathology of Warthin tumor in the parotid gland. Another view of a file "Warthin tumor (1).jpg". H&E stain.
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Histopathology of Warthin tumor in the parotid gland. Higher magnification of a file "Warthin tumor (1).jpg". H&E stain.
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Intermediate magnification micrograph of a Warthin tumor.
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High magnification micrograph of a Warthin tumor showing the characteristic bilayered epithelium.
See also
References
- ^ Witt, Robert L. (ed.) (2005). "Chapter 9 "Benign tumors, cysts, and tumor-like conditions of the salivary glands". Salivary Gland Diseases: Surgical and Medical Management. New York: Thieme Medical Publishers. p. 123. ISBN 1-58890-414-8.
- ^ Kumar V, Abbas AK, Fausto N (2005). Robbins and Cotran pathologic basis of disease, 7 Ed. St. Louis, MO: Elsevier Saunders. ISBN 0-7216-0187-1.
Additional sources
- Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
External links
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Wikimedia Commons has media related to Warthin's tumor. |
- Doctor's Doctor
- Picture
- Photo
- Overview
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Glandular and epithelial neoplasms (ICD-O 8010-8589)
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| Epithelium |
Papilloma/carcinoma
(8010-8139) |
- Small cell carcinoma
- Combined small cell carcinoma
- Verrucous carcinoma
- Squamous cell carcinoma
- Basal cell carcinoma
- Transitional cell carcinoma
- Inverted papilloma
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| Glands |
Adenomas/
adenocarcinomas
(8140-8429) |
| Gastrointestinal |
- tract: Linitis plastica
- Familial adenomatous polyposis
- pancreas
- Insulinoma
- Glucagonoma
- Gastrinoma
- VIPoma
- Somatostatinoma
- Cholangiocarcinoma
- Klatskin tumor
- Hepatocellular adenoma/Hepatocellular carcinoma
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| Urogenital |
- Renal cell carcinoma
- Endometrioid tumor
- Renal oncocytoma
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| Endocrine |
- Prolactinoma
- Multiple endocrine neoplasia
- Adrenocortical adenoma/Adrenocortical carcinoma
- Hurthle cell
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| Other/multiple |
- Neuroendocrine tumor
- Adenoid cystic carcinoma
- Oncocytoma
- Clear cell adenocarcinoma
- Apudoma
- Cylindroma
- Papillary hidradenoma
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Adnexal and
skin appendage (8390-8429) |
- sweat gland
- Syringocystadenoma papilliferum
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Cystic, mucinous,
and serous (8440-8499) |
| Cystic general |
- Cystadenoma/Cystadenocarcinoma
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| Mucinous |
- Signet ring cell carcinoma
- Mucinous cystadenoma / Mucinous cystadenocarcinoma
- Mucoepidermoid carcinoma
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| Serous |
- Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / Papillary serous cystadenocarcinoma
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Ductal, lobular,
and medullary (8500-8549) |
| Ductal carcinoma |
- Mammary ductal carcinoma
- Pancreatic ductal carcinoma
- Comedocarcinoma
- Paget's disease of the breast / Extramammary Paget's disease
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| Lobular carcinoma |
- Lobular carcinoma in situ
- Invasive lobular carcinoma
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| Medullary carcinoma |
- Medullary carcinoma of the breast
- Medullary thyroid cancer
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| Acinar cell (8550-8559) |
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| Other |
| Complex epithelial (8560-8589) |
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- See also
- Template:Epithelium and epithelial tissue
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Tumors of lip, oral cavity and pharynx / head and neck cancer (C00–C14/D10–D11, 140–149/210)
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| Oral cancer |
| Salivary gland |
| malignant epithelial tumors |
- Acinic cell carcinoma
- Mucoepidermoid carcinoma
- Adenoid cystic carcinoma
- Salivary duct carcinoma
- Epithelial-myoepithelial carcinoma
- Polymorphous low-grade adenocarcinoma
- Hyalinizing clear cell carcinoma
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| benign epithelial tumors |
- Pleomorphic adenoma
- Warthin's tumor
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| ungrouped: |
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| Tongue |
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Index of the mouth
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| Description |
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| Disease |
- Congenital
- face and neck
- cleft
- digestive system
- Neoplasms and cancer
- Other
- Symptoms and signs
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| Treatment |
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UpToDate Contents
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- 1. 唾液腺腫瘍：疫学、診断、評価、および病期分類 salivary gland tumors epidemiology diagnosis evaluation and staging
- 2. 頭頸部腫瘍の病理 pathology of head and neck neoplasms
- 3. 唾液腺腫瘍：限局性疾患の治療 salivary gland tumors treatment of locoregional disease
- 4. 頚部腫瘤の鑑別診断 differential diagnosis of a neck mass
English Journal
- Two-phase helical computed tomography study of salivary gland warthin tumors: a radiologic findings and surgical applications.
- Joo YH1, Kim JP1, Park JJ1, Woo SH2.
- Clinical and experimental otorhinolaryngology.Clin Exp Otorhinolaryngol.2014 Sep;7(3):216-21. doi: 10.3342/ceo.2014.7.3.216. Epub 2014 Aug 1.
- OBJECTIVES: The goal of this study was to define the radiologic characteristics of two-phase computed tomography (CT) of salivary gland Warthin tumors and to compare them to pleomorphic adenomas. We also aimed to provide a foundation for selecting a surgical method on the basis of radiologic finding
- PMID 25177439
- Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor.
- Aga M1, Kondo S1, Yamada K2, Wakisaka N1, Yagi-Nakanishi S1, Tsuji A1, Endo K1, Murono S1, Ito M1, Muramatsu M3, Kawano M2, Yoshizaki T4.
- Human pathology.Hum Pathol.2014 Apr;45(4):793-801. doi: 10.1016/j.humpath.2013.11.012. Epub 2013 Dec 2.
- We previously reported a case of immunoglobulin (Ig)G4-related immune inflammation in Warthin tumor. Increased serum IgG4 levels and tissue infiltration of IgG4-positive plasma cells are characteristics of IgG4-related disease (IgG4-RD), a newly emerging clinicopathological entity. However, the rela
- PMID 24565204
- Lymphadenoma of the salivary gland: Report of 10 cases.
- Liu G1, He J2, Zhang C3, Fu S1, He Y2.
- Oncology letters.Oncol Lett.2014 Apr;7(4):1097-1101. Epub 2014 Jan 24.
- Lymphadenoma of the salivary gland is rare, and the typical characteristics of lymphadenoma remain poorly understood. The aim of this study was to analyze the experience of a single institution in the clinical diagnosis, treatment and prognosis of this type of tumor of the salivary gland. All cases
- PMID 24944675
Japanese Journal
- Malignant Lymphoma Arising from Heterotopic Warthin's Tumor in the Neck : Case Report and Review of the Literature
- GORAI SHIGEKI,NUMATA TSUTOMU,KAWADA SAWAKO,NAKANO MASAYUKI,TAMARU JUN-ICHI,KOBAYASHI TOSHIMITSU
- THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 212(2), 199-205, 2007-06-01
- NAID 10019574692
Related Links
- 腺リンパ腫 (adenolymphoma) とは、唾液腺腫瘍の2-15%を占める、比較的稀な良性 上皮性腫瘍の組織型である（紛らわしい名称であるが、リンパ球は反応性に集簇して いるだけであって新生物ではない）。最近は誤解を避けるために、この疾患の発表 ...
- Not to be confused with Wharton's duct (submandibular duct). Warthin's tumor or Warthin tumour, also known as papillary cystadenoma lymphomatosum, monomorphic adenoma or adenolymphoma, is a type of benign tumor of the salivary ...
Related Pictures
