WordNet

of or relating to or resembling a cyst
of or relating to a normal cyst (as the gallbladder or urinary bladder)
any malignant tumor derived from epithelial tissue; one of the four major types of cancer
a closed sac that develops abnormally in some body structure
relating to or resembling lymphatic glands or lymphoid tissue

PrepTutorEJDIC

胞嚢(ほうのう)性の
がん,がん腫
胞嚢(ほうのう)
《複数形》アデノイド,腺(せん)様増殖症(扁桃腺の病気)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/28 19:13:55」(JST)

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Adenoid cystic carcinoma (AdCC) is a rare type of cancer that can exist in many different body sites. It most often occurs in the areas of the head and neck, in particular the salivary glands; but has also been reported in the breast, lacrimal gland of the eye, lung, brain, bartholin gland, trachea, and the paranasal sinuses. It is sometimes referred to as adenocyst, malignant cylindroma, adenocystic, adenoidcystic, ACC, AdCC.

It is the third most common malignant salivary gland tumor overall (after mucoepidermoid carcinoma and polymorphous low grade adenocarcinoma). It represents 28% of malignant submandibular gland tumors, making it the single most common malignant salivary gland tumor in this region. Patients may survive for years with metastases because this tumor is generally well-differentiated and slow growing. In a 1999 study^[1] of a cohort of 160 ACC patients, disease specific survival was 89% at 5 years but only 40% at 15 years,^[2] reflecting deaths from late-occurring metastatic disease.

Treatment

Primary treatment for this cancer, regardless of body site, is surgical removal with clean margins. This surgery can prove challenging in the head and neck region due to this tumour's tendency to spread along nerve tracts. Adjuvant or palliative radiotherapy is commonly given following surgery. For advanced major and minor salivary gland tumors that are inoperable, recurrent, or exhibit gross residual disease after surgery, fast neutron therapy is widely regarded as the most effective form of treatment.^[3]^[4]^[5]^[6] Chemotherapy is used for metastatic disease. Chemotherapy is considered on a case by case basis, as there is limited trial data on the positive effects of chemotherapy. Clinical studies are ongoing, however.^{[citation needed]}

Images

Coronal MRI showing right parotid adenoid cystic carcinoma with perineural spread of tumor. The tumor originates in the right parotid gland and spreads along the trigeminal nerve via the auricuotemporal branch extending intracranially through the foramen ovale at the skull base towards Meckel's cave

Coronal MRI showing right parotid adenoid cystic carcinoma with perineural spread of tumor along the facial nerve extending to the stylomastoid foramen

Histopathological image of adenoid cystic carcinoma of the salivary gland. Hematoxylin & eosin stain.

Histopathological image of adenoid cystic carcinoma of the salivary gland. Immunostain for S-100 protein.

Micrograph of adenoid cystic carcinoma. FNA specimen. Pap stain.

Adenoid cystic carcinoma with comedonecrosis

References

^ Fordice, Jim; Kershaw, Corey; El-Naggar, Adel; Goepfert, Helmuth (February 1999). "Adenoid Cystic Carcinoma of the Head and Neck: Predictors of Morbidity and Mortality". Archives of Otolaryngology--Head & Neck Surgery 125 (2): 149–52. doi:10.1001/archotol.125.2.149. PMID 10037280.
^ Christopher Moskaluk, MD, PhD, and Henry F. Frierson, Jr., MD. "Adenoid Cystic Carcinoma." [1]^{[dead link]}^{[self-published source?]}
^ Laramore, GE (September 1987). "Fast neutron radiotherapy for inoperable salivary gland tumors: is it the treatment of choice?". International Journal of Radiation Oncology, Biology, Physics 13 (9): 1421–3. doi:10.1016/0360-3016(87)90240-9. PMID 3114190.
^ Prott FJ, Haverkamp U, Willich N, Wagner W, Micke O, Pötter R (1996). "Ten years of fast neutron therapy in Münster". Bulletin Du Cancer. Radiothérapie 83 (Suppl): 115s–21s. PMID 8949762.
^ Douglas, James G; Laramore, George E; Austin-Seymour, Mary; Koh, Wui-jin; Stelzer, Keith; Griffin, Thomas W (February 2000). "Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy". International Journal of Radiation Oncology, Biology, Physics 46 (3): 551–7. doi:10.1016/S0360-3016(99)00445-9. PMID 10701733. Cite uses deprecated parameters (help)
^ Breteau N, Wachter T, Kerdraon R, et al. (2000). "Utilisation des neutrons rapides dans le traitement des tumeurs des glandes salivaires : rationnel, revue de la littérature et expérience d'Orléans" [Use of fast neutrons in the treatment of tumors of the salivary glands: rationale, review of the literature and experience in Orleans]. Cancer Radiothérapie (in French) 4 (3): 181–90. doi:10.1016/S1278-3218(00)89092-7. PMID 10897760.

External links

Adenoid Cystic Carcinoma Research Foundation
FAQ for patients at Adenoid Cystic Carcinoma Organization International
Adenoid Cystic Carcinoma Information
Cancer.Net: Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma at Oral Cancer Foundation
[2] Search for clinical trials at ClinicalTrials.gov
[3] Search for research literature at PubMed.gov
[4] Search for consumer health information at Medlineplus.gov
Cancer.Net: Lacrimal Gland Tumor

UpToDate Contents

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1. 悪性唾液腺腫瘍：再発性および転移性疾患の治療 malignant salivary gland tumors treatment of recurrent and metastatic disease
2. 唾液腺腫瘍：疫学、診断、評価、および病期分類 salivary gland tumors epidemiology diagnosis evaluation and staging
3. 気管腫瘍 tracheal tumors
4. 唾液腺腫瘍：限局性疾患の治療 salivary gland tumors treatment of locoregional disease
5. 頭頸部腫瘍の病理 pathology of head and neck neoplasms

English Journal

MicroRNA-181a suppresses salivary adenoid cystic carcinoma metastasis by targeting MAPK-Snai2 pathway.

He Q, Zhou X, Li S, Jin Y, Chen Z, Chen D, Cai Y, Liu Z, Zhao T, Wang A.SourceDepartment of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Nov;1830(11):5258-66. doi: 10.1016/j.bbagen.2013.07.028. Epub 2013 Aug 2.
BACKGROUND: To date microRNAs and their contribution to the onset and propagation of salivary adenoid cystic carcinoma (SACC) are limited. The objective of this study was to identify miR-181a and its mechanism in the metastasis of SACC.METHODS: At first microarray and quantitative RT-PCR were used t
PMID 23911747

Promoting effects on the proliferation and metastasis of ACC tumor cell with XAGE-1b overexpression.

Zhou B, Li T, Liu Y, Zhu N.SourceDepartment of Gerontology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, P.R. China.
Oncology reports.Oncol Rep.2013 Nov;30(5):2323-35. doi: 10.3892/or.2013.2719. Epub 2013 Sep 5.
Adenoid cystic carcinoma is salivary gland malignancy characterized by indolent yet relentless growth that exhibits inherent resistance to surgery, chemotherapy and radiotherapy and it also expresses genes associated with well-defined carcinogenic and metastasis processes. There is no clear role est
PMID 24008415

Japanese Journal

症例報告皮膚浸潤をきたした乳腺腺様嚢胞癌の1例

原田剛佑,折田雅彦,林雅規 [他]
山口医学 = Yamaguchi medical journal 63(1), 43-47, 2014-02
NAID 40019978685

臨床経験皮膚原発腺様囊胞癌の切除21年後に生じた多発肺転移

寺田好孝,豊洋次郎,金田祥平 [他]
胸部外科 = The Japanese journal of thoracic surgery 66(13), 1158-1162, 2013-12
NAID 40019880107

顎下腺原発脱分化型腺様嚢胞癌の1例

李進彰,重田崇至,長谷川巧実 [他]
日本口腔外科学会雑誌 = Japanese journal of oral and maxillofacial surgery 59(9), 588-592, 2013-09
NAID 40019815106

「腺様嚢胞癌」

Adenoid cystic carcinoma
	Classification and external resources
	Micrograph of an adenoid cystic carcinoma of a salivary gland (right of image). Normal serous glands, typical of the parotid gland, are also seen (left of image). H&E stain.
ICD-O:	M8200/3
MeSH	D003528

　　[★]

英: adenoid cystic carcinoma
関: 腺様嚢胞がん、円柱腫

英: adenoid cystic carcinoma

「腺様嚢胞がん」

　　[★]

英: adenoid cystic carcinoma
関: 腺様嚢胞癌

「adeno」

　　[★]

comb form.
アデノ、腺の

関: gland、glandular

「cystic」

　　[★]

adj.

嚢胞性の

[1] Fordice, Jim; Kershaw, Corey; El-Naggar, Adel; Goepfert, Helmuth (February 1999). "Adenoid Cystic Carcinoma of the Head and Neck: Predictors of Morbidity and Mortality". Archives of Otolaryngology--Head & Neck Surgery 125 (2): 149–52. doi:10.1001/archotol.125.2.149. PMID 10037280.

[2] Christopher Moskaluk, MD, PhD, and Henry F. Frierson, Jr., MD. "Adenoid Cystic Carcinoma." [1]^{[dead link]}^{[self-published source?]}

[3] Laramore, GE (September 1987). "Fast neutron radiotherapy for inoperable salivary gland tumors: is it the treatment of choice?". International Journal of Radiation Oncology, Biology, Physics 13 (9): 1421–3. doi:10.1016/0360-3016(87)90240-9. PMID 3114190.

[4] Prott FJ, Haverkamp U, Willich N, Wagner W, Micke O, Pötter R (1996). "Ten years of fast neutron therapy in Münster". Bulletin Du Cancer. Radiothérapie 83 (Suppl): 115s–21s. PMID 8949762.

[5] Douglas, James G; Laramore, George E; Austin-Seymour, Mary; Koh, Wui-jin; Stelzer, Keith; Griffin, Thomas W (February 2000). "Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy". International Journal of Radiation Oncology, Biology, Physics 46 (3): 551–7. doi:10.1016/S0360-3016(99)00445-9. PMID 10701733. Cite uses deprecated parameters (help)

[6] Breteau N, Wachter T, Kerdraon R, et al. (2000). "Utilisation des neutrons rapides dans le traitement des tumeurs des glandes salivaires : rationnel, revue de la littérature et expérience d'Orléans" [Use of fast neutrons in the treatment of tumors of the salivary glands: rationale, review of the literature and experience in Orleans]. Cancer Radiothérapie (in French) 4 (3): 181–90. doi:10.1016/S1278-3218(00)89092-7. PMID 10897760.

リンク元	「腺様嚢胞癌」「腺様嚢胞がん」
関連記事	「adeno」「cystic」

匿名

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案内

案内

adenoid cystic carcinoma