ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle.
Meex RC1, Hoy AJ2, Mason RM1, Martin SD3, McGee SL3, Bruce CR4, Watt MJ5.
American journal of physiology. Endocrinology and metabolism.Am J Physiol Endocrinol Metab.2015 Jun 1;308(11):E960-70. doi: 10.1152/ajpendo.00598.2014. Epub 2015 Apr 7.
Emerging evidence indicates that skeletal muscle lipid droplets are an important control point for intracellular lipid homeostasis and that regulating fatty acid fluxes from lipid droplets might influence mitochondrial capacity. We used pharmacological blockers of the major triglyceride lipases, adi
Recombinant adeno-associated virus-, polyethylenimine/plasmid- and lipofectamine/carboxyfluorescein-labeled small interfering RNA-based transfection in retinal pigment epithelial cells with ultrasound and/or SonoVue.
Li H1, Wan C1, Li F1.
Molecular medicine reports.Mol Med Rep.2015 May;11(5):3609-14. doi: 10.3892/mmr.2015.3219. Epub 2015 Jan 19.
The present study was conducted to investigate the efficacy and safety of ultrasound (US)‑mediated transfection of the type 2 recombinant adeno‑associated virus (AAV) vectors encoding the enhanced green fluorescent protein (EGFP) gene (rAAV), polyethylenimine (PEI)/plasmid EGFP‑N1 (pDNA) or li
Therapeutic delivery of cyclin-A2 via recombinant adeno-associated virus serotype 9 restarts the myocardial cell cycle: an in vitro study.
Ma X1, Zhao A1, Yao Y1, Cao W1, Karmacharya U1, Liu F1, Chen B1, Baozhu W1, Ying H1, Ma Y1.
Molecular medicine reports.Mol Med Rep.2015 May;11(5):3652-8. doi: 10.3892/mmr.2015.3147. Epub 2015 Jan 7.
Cyclin‑A2, which is downregulated following birth, has previously been established as a key regulator of the cell cycle. The present study aimed to detect the effects of cyclin‑A2 on myocardial cells by using recombinant adeno‑associated virus 9 (rAAV9). Sixty mice were selected and randomly d
2 Adenoassociated Virus Vector for Gene Therapy(Advanced Strategies in Cardiovascular Medicine and Translational Research,Presidential Planning Program,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Circulation journal : official journal of the Japanese Circulation Society 72(Supplement_I), 135, 2008-03-01
adenoassociated virus (AAV) [ad′ənō-] a defective virus belonging to a group of DNA viruses of the Parvoviridae family that can reproduce only in the presence of adenoviruses. It is not yet known what role, if any, these organisms have ...
Adeno-Associated Virus A member of the parvovirus family, which is composed of small viruses with a genome of a single-stranded DNA. AAVs insert genomic material at a specific site on human chromosome 19 with nearly 100% ...