アデニンデアミナーゼ
WordNet
- (biochemistry) purine base found in DNA and RNA; pairs with thymine in DNA and with uracil in RNA (同)A
PrepTutorEJDIC
- アデニン(肝臓・茶の葉から採れる塩基の一種)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/04/12 21:19:04」(JST)
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adenine deaminase |
Identifiers |
EC number |
3.5.4.2 |
CAS number |
9027-68-3 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
|
In enzymology, an adenine deaminase (EC 3.5.4.2) is an enzyme that catalyzes the chemical reaction
- adenine + H2O hypoxanthine + NH3
Thus, the two substrates of this enzyme are adenine and H2O, whereas its two products are hypoxanthine and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is adenine aminohydrolase. Other names in common use include adenase, adenine aminase, and ADase. This enzyme participates in purine metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2ICS.
References
- Blauch M, Koch FC and Hane ME (1939). "A study of xanthine oxidase of rat blood". J. Biol. Chem. 130: 471–486.
- Heppel LA, Hurwitz J and Horecker BL (1957). "Adenine deaminase of Azotobacter vinelandii". J. Am. Chem. Soc. 79 (3): 630–633. doi:10.1021/ja01560a033.
UpToDate Contents
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English Journal
- A novel enzymatic approach in the production of food with low purine content using Arxula adeninivorans endogenous and recombinant purine degradative enzymes.
- Jankowska DA1, Trautwein-Schult A, Cordes A, Bode R, Baronian K, Kunze G.
- Bioengineered.Bioengineered.2015;6(1):20-5. doi: 10.4161/21655979.2014.991667. Epub 2015 Jan 8.
- The purine degradation pathway in humans ends with uric acid, which has low water solubility. When the production of uric acid is increased either by elevated purine intake or by impaired kidney function, uric acid will accumulate in the blood (hyperuricemia). This increases the risk of gout, a dise
- PMID 25513995
- Effects of iron supplementation on blood adenine deaminase activity and oxidative stress in Trypanosoma evansi infection of rats.
- Bottari NB1, Baldissera MD2, Tonin AA2, França RT3, Zanini D4, Leal ML5, Lopes ST3, Schetinger MR4, Morsch VM4, Monteiro SG2, Guarda NS6, Moresco RN6, Aires AR5, Stefani LM7, Da Silva AS8.
- Experimental parasitology.Exp Parasitol.2014 Dec;147:1-6. doi: 10.1016/j.exppara.2014.09.002. Epub 2014 Oct 6.
- The aim of this study was to assess the effects of iron supplementation on oxidative stress and on the activity of the adenosine deaminase (ADA) in rats experimentally infected by Trypanosoma evansi. For this purpose, 20 rats were divided into four experimental groups with five animals each as follo
- PMID 25300765
- Adenine deaminase is encoded by Tad1 and participates in copper accumulation in Trichoderma reesei.
- Fu K1, Fan L1, Yu C1, Li Y1, Gao S1, Li Y1, Chen J2.
- Fungal genetics and biology : FG & B.Fungal Genet Biol.2014 Feb;63:17-23. doi: 10.1016/j.fgb.2013.11.004. Epub 2013 Nov 25.
- We cloned a novel Tad1 gene and demonstrated that this gene is closely involved in copper bioaccumulation in Trichoderma reesei. Tad1 gene encodes a 510 amino acids protein of the amidohydrolase superfamily which belongs to COG0402. We found that adenine was the most efficient substrate of Tad1 prot
- PMID 24286717
Japanese Journal
- Different mechanisms of extracellular adenosine accumulation by reduction of the external Ca2+ concentration and inhibition of adenosine metabolism in spinal astrocytes
- Uptake of AMP, ADP, and ATP in Escherichia coli W
- Bioscience, biotechnology, and biochemistry 75(1), 7-12, 2011-01-23
- NAID 10027896383
- Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats
Related Links
- adenine deaminase activity, catalase activity, ferrous iron binding, manganese ion binding, adenine catabolic process, hypoxanthine biosynthetic process, oxidation-reduction process ... You are using a version of browser that may ...
- Adenine deaminase (EC:3.5.4.2) hydrolyses adenine to form hypoxanthine and ammonia. The enzyme is part of a large metal dependent hydrolase superfamily [PMID: 9144792]. The adenine deaminase reaction is important for adenine ...
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デアミナーゼ、脱アミノ酵素