アクチニン
- 関
- alpha-actinin、beta-actinin
WordNet
- one of the proteins into which actomyosin can be split; can exist in either a globular or a fibrous form
PrepTutorEJDIC
- 純蛋白質(筋肉生成に役立つ)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/18 21:11:11」(JST)
[Wiki en表示]
Actinin is a microfilament protein. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells,[1] and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.
The non-sarcomeric α-actinins (ACTN1 and ACTN4) are widely expressed. Both ends of the rod-shaped α-actinin dimer contain actin-binding domains.
Mutations in ACTN4 can cause the kidney disease focal segmental glomerulosclerosis.
Contents
- 1 Genes
- 2 See also
- 3 References
- 4 External links
Genes
- ACTN1, ACTN2, ACTN3, ACTN4
See also
References
- ^ Ganong's Review of Medical Physiology, 24th Edition. Lange (Tata McGraw Hill). 2012. p. 100.
External links
- Actinin at the US National Library of Medicine Medical Subject Headings (MeSH)
Proteins of the cytoskeleton
|
|
Human |
|
|
Nonhuman |
- Major sperm proteins
- Prokaryotic cytoskeleton
|
|
See also: cytoskeletal defects B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Rodent models for resolving extremes of exercise and health.
- Garton FC1, North KN2, Koch LG3, Britton SL4, Nogales-Gadea G5, Lucia A6.
- Physiological genomics.Physiol Genomics.2016 Feb;48(2):82-92. doi: 10.1152/physiolgenomics.00077.2015. Epub 2015 Sep 22.
- The extremes of exercise capacity and health are considered a complex interplay between genes and the environment. In general, the study of animal models has proven critical for deep mechanistic exploration that provides guidance for focused and hypothesis-driven discovery in humans. Hypotheses unde
- PMID 26395598
- ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells.
- Valiya Veettil M1, Kumar B2, Ansari MA2, Dutta D2, Iqbal J2, Gjyshi O2, Bottero V2, Chandran B2.
- Journal of virology.J Virol.2016 Jan 27. pii: JVI.02704-15. [Epub ahead of print]
- Kaposi's sarcoma-associated herpesvirus (KSHV) enters human dermal microvascular endothelial cells (HMVEC-d), its natural in vivo target cells, by lipid raft dependent macropinocytosis. The internalized viral envelope fuses with the macropinocytic membrane and released capsid is transported to the n
- PMID 26819309
- How does α-actinin-3 deficiency alter muscle function? Mechanistic insights into ACTN3, the 'gene for speed'.
- Lee FX1, Houweling PJ2, North KN3, Quinlan KG4.
- Biochimica et biophysica acta.Biochim Biophys Acta.2016 Jan 21. pii: S0167-4889(16)30003-9. doi: 10.1016/j.bbamcr.2016.01.013. [Epub ahead of print]
- An estimated 1.5 billion people worldwide are deficient in the skeletal muscle protein α-actinin-3 due to homozygosity for the common ACTN3 R577X polymorphism. α-Actinin-3 deficiency influences muscle performance in elite athletes and the general population. The sarcomeric α-actinins were origina
- PMID 26802899
Japanese Journal
- 1A-O-2 The expressions of alpha-actinin isoforms in rat damaged muscle(The Proceedings of the 18th Annual Meetings of Japan Society Exercise and Sports Physiology Jury 31 August 1, (Kagoshima))
- KAKIGI Ryo,NAITO Hisashi,OGURA Yuji,FUKAI Yuto,YOSHIHARA Toshinori,KATAMOTO Shizuo
- Advances in exercise and sports physiology 16(2), 43, 2010-11
- NAID 110007988720
- Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4.
- Kumeta Masahiro,Yoshimura Shige H,Harata Masahiko,Takeyasu Kunio
- Journal of cell science 123(Pt 7), 1020-1030, 2010-03-02
- … In addition to its well-known role as a crosslinker of actin filaments at focal-adhesion sites, actinin-4 is known to be localized to the nucleus. … In this study, we reveal the molecular mechanism underlying nuclear localization of actinin-4 and its novel interactions with transcriptional regulators. … We found that actinin-4 is imported into the nucleus through the nuclear pore complex in an importin-independent manner and is exported by the chromosome region maintenance-1 (CRM1)-dependent pathway. …
- NAID 120002561115
Related Links
- 米国CST社の日本法人CSTジャパン株式会社【公式サイト】α-Actinin Antibodyページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
- ... Ebashi S, Ebashi F. Alpha-actinin, a new structural protein from striated muscle. I. Preparation and action on actomyosin-atp interaction. J Biochem (Tokyo). 58:7-12, 1965 (PMID: 5857104) 2) Honda K, Yamada T, Endo R ) ) ) ) ...
Related Pictures
![Alpha (α)-actinin](https://1mg.info/0/5/z/0601.jpg)
![Actinin Products](https://1mg.info/0/5/z/0602.jpg)
![Brainerd Lab: Phalloidin/Alpha-actinin](https://1mg.info/0/5/z/0603.jpg)
![Figure actinin::](https://1mg.info/0/5/z/0604.jpg)
![Sarcomeric Alpha Actinin Anti-Sarcom](https://1mg.info/0/5/z/0605.jpg)
★リンクテーブル★
[★]
- 英
- actinin
- 関
- αアクチニン、βアクチニン
[★]
βアクチニン
- 関
- actinin、alpha-actinin
[★]
αアクチニン
- 関
- actinin、beta-actinin