関: alpha-actinin、beta-actinin

WordNet

one of the proteins into which actomyosin can be split; can exist in either a globular or a fibrous form

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純蛋白質(筋肉生成に役立つ)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/18 21:11:11」(JST)

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Actinin is a microfilament protein. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells,^[1] and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.

The non-sarcomeric α-actinins (ACTN1 and ACTN4) are widely expressed. Both ends of the rod-shaped α-actinin dimer contain actin-binding domains.

Mutations in ACTN4 can cause the kidney disease focal segmental glomerulosclerosis.

Genes

ACTN1, ACTN2, ACTN3, ACTN4

References

^ Ganong's Review of Medical Physiology, 24th Edition. Lange (Tata McGraw Hill). 2012. p. 100.

External links

Actinin at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. 巣状分節性糸球体硬化症の疫学、分類、および病因 epidemiology classification and pathogenesis of focal segmental glomerulosclerosis
2. 糸球体足細胞のバイオロジー biology of glomerular podocytes
3. 先天性乳児ネフローゼ症候群 congenital and infantile nephrotic syndrome
4. 移植腎における巣状分節性糸球体硬化症 focal segmental glomerulosclerosis in the transplanted kidney
5. 重症蛋白尿およびネフローゼ症候群の概要 overview of heavy proteinuria and the nephrotic syndrome

English Journal

Rodent models for resolving extremes of exercise and health.

Garton FC1, North KN2, Koch LG3, Britton SL4, Nogales-Gadea G5, Lucia A6.
Physiological genomics.Physiol Genomics.2016 Feb;48(2):82-92. doi: 10.1152/physiolgenomics.00077.2015. Epub 2015 Sep 22.
The extremes of exercise capacity and health are considered a complex interplay between genes and the environment. In general, the study of animal models has proven critical for deep mechanistic exploration that provides guidance for focused and hypothesis-driven discovery in humans. Hypotheses unde
PMID 26395598

ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells.

Valiya Veettil M1, Kumar B2, Ansari MA2, Dutta D2, Iqbal J2, Gjyshi O2, Bottero V2, Chandran B2.
Journal of virology.J Virol.2016 Jan 27. pii: JVI.02704-15. [Epub ahead of print]
Kaposi's sarcoma-associated herpesvirus (KSHV) enters human dermal microvascular endothelial cells (HMVEC-d), its natural in vivo target cells, by lipid raft dependent macropinocytosis. The internalized viral envelope fuses with the macropinocytic membrane and released capsid is transported to the n
PMID 26819309

How does α-actinin-3 deficiency alter muscle function? Mechanistic insights into ACTN3, the 'gene for speed'.

Lee FX1, Houweling PJ2, North KN3, Quinlan KG4.
Biochimica et biophysica acta.Biochim Biophys Acta.2016 Jan 21. pii: S0167-4889(16)30003-9. doi: 10.1016/j.bbamcr.2016.01.013. [Epub ahead of print]
An estimated 1.5 billion people worldwide are deficient in the skeletal muscle protein α-actinin-3 due to homozygosity for the common ACTN3 R577X polymorphism. α-Actinin-3 deficiency influences muscle performance in elite athletes and the general population. The sarcomeric α-actinins were origina
PMID 26802899

Japanese Journal

1A-O-2 The expressions of alpha-actinin isoforms in rat damaged muscle(The Proceedings of the 18th Annual Meetings of Japan Society Exercise and Sports Physiology Jury 31 August 1, (Kagoshima))

KAKIGI Ryo,NAITO Hisashi,OGURA Yuji,FUKAI Yuto,YOSHIHARA Toshinori,KATAMOTO Shizuo
Advances in exercise and sports physiology 16(2), 43, 2010-11
NAID 110007988720

Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4.

Kumeta Masahiro,Yoshimura Shige H,Harata Masahiko,Takeyasu Kunio
Journal of cell science 123(Pt 7), 1020-1030, 2010-03-02
… In addition to its well-known role as a crosslinker of actin filaments at focal-adhesion sites, actinin-4 is known to be localized to the nucleus. … In this study, we reveal the molecular mechanism underlying nuclear localization of actinin-4 and its novel interactions with transcriptional regulators. … We found that actinin-4 is imported into the nucleus through the nuclear pore complex in an importin-independent manner and is exported by the chromosome region maintenance-1 (CRM1)-dependent pathway. …
NAID 120002561115