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English Journal

Paroxysmal nocturnal hemoglobinuria (PNH) and primary p.Cys89Tyr mutation in CD59: Differences and similarities.

Mevorach D1.
Molecular immunology.Mol Immunol.2015 Sep;67(1):51-5. doi: 10.1016/j.molimm.2015.03.005. Epub 2015 Mar 26.
CD59 encodes a 77 amino acid glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that inhibits the final step of membrane attack complex (MAC) formation. CD59 deficiency is a common finding in adult patients with paroxysmal nocturnal hemoglobinuria (PNH). In this condition, there i
PMID 25818314

Oligosaccharide modification by N-acetylglucosaminyltransferase-V in macrophages are involved in pathogenesis of bleomycin-induced scleroderma.

Kato A1,2, Yutani M1,2, Terao M1, Kimura A1,2, Itoi S1, Murota H1, Miyoshi E2, Katayama I1.
Experimental dermatology.Exp Dermatol.2015 Aug;24(8):585-90. doi: 10.1111/exd.12730. Epub 2015 May 26.
Oligosaccharide modification by N-acetylglucosaminyltransferase-V (GnT-V), which catalyses the formation of β1,6 GlcNAc (N-acetylglucosamine) branches on N-glycans, is associated with various pathologies, such as cancer metastasis, multiple sclerosis and liver fibrosis. In this study, we demonstrat
PMID 25876794

Abnormal N-acetylglucosaminyltransferase expression in prefrontal cortex in schizophrenia.

Kippe JM1, Mueller TM2, Haroutunian V3, Meador-Woodruff JH2.
Schizophrenia research.Schizophr Res.2015 Aug;166(1-3):219-24. doi: 10.1016/j.schres.2015.06.002. Epub 2015 Jun 20.
Changes in the extent of the posttranslational modification glycosylation have been previously reported in several brain regions in schizophrenia. Quality control within the endoplasmic reticulum and Golgi, branching of glycans, intracellular trafficking and targeting, protein-protein interactions,
PMID 26104473

ISP-4-2 The expression of N-acetylglucosaminyltransferase IVa in gestational trophoblastic diseases and the function in Jar choriocarcinoma cells(Group 4 Oncology 4,IS Poster,International Session)

Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer

Nakayama Jun
ACTA HISTOCHEMICA ET CYTOCHEMICA 47(1), 1-9, 2014
… These mucins typically contain O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc) attached to the scaffold protein MUC6, and biosynthesis of the O-glycans is catalyzed by the glycosyltransferase, α1,4-N-acetylglucosaminyltransferase (α4GnT). …
NAID 130003390844