アセチルエステラーゼ
- 関
- acetylase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/12/11 00:29:17」(JST)
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acetylesterase |
Identifiers |
EC number |
3.1.1.6 |
CAS number |
9000-82-2 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
In enzymology, an acetylesterase (EC 3.1.1.6) is an enzyme that catalyzes the chemical reaction
- an acetic ester + H2O an alcohol + acetate
Thus, the two substrates of this enzyme are acetic ester and H2O, whereas its two products are alcohol and acetate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is acetic-ester acetylhydrolase. Other names in common use include C-esterase (in animal tissues), acetic ester hydrolase, chloroesterase, p-nitrophenyl acetate esterase, and Citrus acetylesterase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BS9, 1G66, and 2AXE.
References
- ALDRIDGE WN (1953). "Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination". Biochem. J. 53 (1): 110–7. PMC 1198110. PMID 13032041.
- Bergmann F and Rimon S (1960). "Fractionation of C-esterase from the hog's kidney extract" (PDF). Biochem. J. 77 (2): 209–214. PMC 1204974. PMID 16748846.
- Jansen EF, Nutting M-DF and Balls AK (1948). "The reversible inhibition of acetylesterase by diisopropyl fluorophosphate and tetraethyl pyrophosphate" (PDF). J. Biol. Chem. 175 (2): 975–987. PMID 18880795.
English Journal
- Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme.
- Huang X1, Dong W2, Milewska A3, Golda A3, Qi Y4, Zhu QK5, Marasco WA5, Baric RS6, Sims AC7, Pyrc K8, Li W9, Sui J9.
- Journal of virology.J Virol.2015 Jul 15;89(14):7202-13. doi: 10.1128/JVI.00854-15. Epub 2015 Apr 29.
- Human coronavirus (hCoV) HKU1 is one of six hCoVs identified to date and the only one with an unidentified cellular receptor. hCoV-HKU1 encodes a hemagglutinin-esterase (HE) protein that is unique to the group a betacoronaviruses (group 2a). The function of HKU1-HE remains largely undetermined. In t
- PMID 25926653
- Crystal structure of an acetylesterase from Talaromyces cellulolyticus and the importance of a disulfide bond near the active site.
- Watanabe M1, Fukada H2, Inoue H1, Ishikawa K3.
- FEBS letters.FEBS Lett.2015 May 8;589(11):1200-6. doi: 10.1016/j.febslet.2015.03.020. Epub 2015 Mar 28.
- Carbohydrate esterase catalyzes the de-O or de-N-acylation of substituted saccharides in plant cell walls and thus has great potential for industrial biomass saccharification. We recently identified the putative carbohydrate esterase family 3 (CE3) from Talaromyces cellulolyticus. Here, we prepared
- PMID 25825334
- Structural and biochemical characterization of a carbohydrate acetylesterase from Sinorhizobium meliloti 1021.
- Kim K1, Ryu BH2, Kim SS1, An DR2, Ngo TD1, Pandian R1, Kim KK3, Kim TD4.
- FEBS letters.FEBS Lett.2015 Jan 2;589(1):117-22. doi: 10.1016/j.febslet.2014.11.033. Epub 2014 Nov 29.
- In many microorganisms, carbohydrate acetylesterases remove the acetyl groups from various types of carbohydrates. Sm23 from Sinorhizobium meliloti is a putative member of carbohydrate esterase family 3 (CE3) in the CAZy classification system. Here, we determined the crystal structure of Sm23 at 1.7
- PMID 25436419
Japanese Journal
- Sequence Analysis and Heterologous Expression of Two Rhamnogalacturonan Acetylesterase Genes (<i>Asrgae1</i> and <i>Asrgaea2</i>) from a <i>Shoyu Koji</i> Mold, <i>Aspergillus sojae</i> KBN1340
- A missense single-nucleotide polymorphism in the sialic acid acetylesterase (<i>SIAE</i>) gene is associated with anti–PIT-1 antibody syndrome
- Determination of Enzymes from Colletotrichum sp. AHU9748 Essential for Lepidimoide Production from Okra Polysaccharide(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Journal of bioscience and bioengineering 102(5), 452-456, 2006-11-25
- NAID 110006148697
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アセチラーゼ
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