acetoxyacetylaminofluorene

アセトキシアセチルアミノフルオレン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/28 21:06:40」(JST)

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Acetoxyacetylaminofluorene
IUPAC name [Acetyl(9H-fluoren-2-yl)amino] acetate
Other names N-Acetoxy-2-acetamidofluorene; N-Acetoxy-2-acetylaminofluorene; Acetoxy AAF; Acetoxyacetamidofluorene; Acetoxyfluorenylacetamide;
Identifiers
Abbreviations	NAAAF
CAS number	6098-44-8 N
PubChem	22469
ChemSpider	21074 Y
MeSH	Acetoxyacetylaminofluorene
ChEBI	CHEBI:234426 N
ChEMBL	CHEMBL85327 Y
Jmol-3D images	Image 1 Image 2
SMILES CC(=O)ON(C(C)=O)c1ccc-2c(Cc3ccccc-23)c1 CC(=O)ON(C(C)=O)C1=CC=C2C(CC3=C2C=CC=C3)=C1
InChI InChI=1S/C17H15NO3/c1-11(19)18(21-12(2)20)15-7-8-17-14(10-15)9-13-5-3-4-6-16(13)17/h3-8,10H,9H2,1-2H3 Y Key: NFOMHWALMFWNAQ-UHFFFAOYSA-N Y InChI=1/C17H15NO3/c1-11(19)18(21-12(2)20)15-7-8-17-14(10-15)9-13-5-3-4-6-16(13)17/h3-8,10H,9H2,1-2H3 Key: NFOMHWALMFWNAQ-UHFFFAOYAD
Properties
Molecular formula	C17H15NO3
Molar mass	281.31 g mol−1
log P	3.327
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N (verify) (what is: Y/N?)
Infobox references

Acetoxyacetylaminofluorene is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis. It forms adducts with DNA by reacting with guanine at its C-8 position.; This results in breaks in one strand of the DNA.

See also

• Hydroxyacetylaminofluorene

References

English Journal

• The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.

• Kemp MG1, Lindsey-Boltz LA, Sancar A.
• The Journal of biological chemistry.J Biol Chem.2011 Jun 3;286(22):19237-46. doi: 10.1074/jbc.M111.235036. Epub 2011 Apr 12.
• A variety of environmental, carcinogenic, and chemotherapeutic agents form bulky lesions on DNA that activate DNA damage checkpoint signaling pathways in human cells. To identify the mechanisms by which bulky DNA adducts induce damage signaling, we developed an in vitro assay using mammalian cell nu
• PMID 21487018

• Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells.

• Mahabir AG1, Schaap MM, Pennings JL, van Benthem J, Hendriksen CF, van Steeg H.
• BMC genomics.BMC Genomics.2010 Jan 12;11:24. doi: 10.1186/1471-2164-11-24.
• BACKGROUND: Previously we found that Rad54/Rad54B cells are more sensitive towards mitomycin C (MMC) as compared to wild-type (WT) cells. This difference in sensitivity was absent upon exposure to other clastogens like bleomycin (BLM) and gamma-radiation. In order to get further insight into possibl
• PMID 20067618

• GenoMass--a computer software for automated identification of oligonucleotide DNA adducts from LC-MS analysis of DNA digests.

• Liao Q1, Shen C, Vouros P.
• Journal of mass spectrometry : JMS.J Mass Spectrom.2009 Apr;44(4):549-60. doi: 10.1002/jms.1532.
• In the investigation of oligonucleotides, DNA and their adducts by LC-MS, a myriad of data are generated that make manual data processing quite difficult. This paper describes a 'reversed pseudo-combinatorial' approach for fragment identification and the software implementation of this approach. Com
• PMID 19053159

Related Links

• Acetoxyacetylaminofluorene - Wikipedia, the free encyclopedia

Acetoxyacetylaminofluorene. From Wikipedia, the free encyclopedia. Jump to: navigation, search. Acetoxyacetylaminofluorene ... Acetoxyacetylaminofluorene is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of ...

• Reactions of methylnitrosourea, epichlorohydrin, styrene oxide and ...

Reactions of methylnitrosourea, epichlorohydrin, styrene oxide and acetoxyacetylaminofluorene with polyamino acids. Hemminki K. Radioactive methylnitrosourea, epichlorohydrin, styrene oxide, and N-acetoxy-2- acetylaminofluorene were ...

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acetoxyacetylaminofluorene