関: ACF

WordNet

utter a characteristic sound; "The cat was crying"
shed tears because of sadness, rage, or pain; "She cried bitterly when she heard the news of his death"; "The girl in the wheelchair wept with frustration when she could not get up the stairs" (同)weep
bring into a particular state by crying; "The little boy cried himself to sleep"
a loud utterance; often in protest or opposition; "the speaker was interrupted by loud cries from the rear of the audience" (同)outcry, call, yell, shout, vociferation
a loud utterance of emotion (especially when inarticulate); "a cry of rage"; "a yell of pain" (同)yell
a fit of weeping; "had a good cry"
the characteristic utterance of an animal; "animal cries filled the night"
proclaim or announce in public; "before we had newspapers, a town crier would cry the news"; "He cried his merchandise in the market square" (同)blazon out
demand immediate action; "This situation is crying for attention"
markedly different from an accepted norm; "aberrant behavior"; "deviant ideas" (同)deviant, deviate
one whose behavior departs substantially from the norm of a group
a cellar or vault or underground burial chamber (especially beneath a church)

PrepTutorEJDIC

(喜び・悲しみ・苦痛などで)『泣く』,涙を流す / 『叫ぶ』《+『out』》 / 〈鳥・獣が〉鳴く,ほえる / …‘と'『叫ぶ』,大声で言う / 〈ニュース〉'を'大声でふれ歩く;〈品物〉'を'呼び売りする / 『叫び[声];(鳥・獣の)鳴き声,ほえ声』 / 『声をあげて泣くこと』,泣き声 / (…に対する,反対する)要求,訴え《+『for』(『against』)+『名』》,(…する)要求《+『to』 do》 / 世論;スローガン,標語
正道からはずれた,常軌を逸した;異常な
地下室,(特に)教会堂の地下室(小礼拝室・納骨室に用いる)
focusの複数形

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/16 08:46:52」(JST)

wiki en

Aberrant crypt foci (ACF) are clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci form before colorectal polyps and are one of the earliest changes seen in the colon that may lead to cancer. ACF are, as opposed to normal epithelial cells, apoptosis resistant. When looking for aberrant crypt foci with microscopy, methylene blue is used as a staining agent.^[1] The resulting figure is fairly easy to detect under the microscope at low magnification (x40).^[2]

Chemically induced ACF in rodents have been used extensively to test chemicals and diets that might prevent colorectal cancer, and reported in more than 400 scientific articles.^[3] The "chemoprevention database" shows the results of all published scientific studies of chemopreventive agents, in people and in animals.^[4]

The relevance of ACF as a surrogate endpoint biomarker for cancer is controversial. Recently, several alternative precancerous lesions have been described (namely MDF, BCAC, and flat ACF), which might be better biomarkers than ACF.^[5]

Resveratrol glucoside from transgenic alfalfa has been used for the prevention of aberrant crypt foci in mice.^[6]

References

^ Takayama T, Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y (Jul 2005). "Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness". Clin Gastroenterol Hepatol. 3 (7 Suppl 1): 42–45. PMID 16012995. doi:10.1016/S1542-3565(05)00257-0.
^ "ACF photos".
^ Corpet DE, Tache S (2002). "Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency". Nutr Cancer. 43 (1): 1–21. PMC 2536533 . PMID 12467130. doi:10.1207/S15327914NC431_1.
^ "Colorectal Cancer Prevention: Chemoprevention Database".
^ "ACF-MDF-BCAC".
^ Resveratrol From Transgenic Alfalfa for Prevention of Aberrant Crypt Foci in Mice. Brian D. Kineman, E. Charles Brummer, Nancy L. Paiva and Diane F. Birt, Nutrition and Cancer, 2010, Volume 62, Issue 3, pages 351-361, doi:10.1080/01635580903407213

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UpToDate Contents

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1. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer
2. 色素内視鏡検査 chromoendoscopy
3. 非ステロイド性抗炎症剤（NSAIDs）（アスピリンを含む）：大腸癌の予防における役割 nsaids including aspirin role in prevention of colorectal cancer

English Journal

Combined therapeutic efficacy of carvacrol and X-radiation against 1,2-dimethyl hydrazine-induced experimental rat colon carcinogenesis.

Arivalagan S1, Thomas NS1, Chandrasekaran B1, Mani V1, Siddique AI1, Kuppsamy T2, Namasivayam N3.
Molecular and cellular biochemistry.Mol Cell Biochem.2015 Dec;410(1-2):37-54. doi: 10.1007/s11010-015-2536-6. Epub 2015 Aug 12.
Colon cancer is one of the most commonly diagnosed cancers, and is a major cause of cancer morbidity and mortality worldwide. The objective of the present study is to evaluate the combined therapeutic efficacy of carvacrol (CVC) and X-radiation against 1,2-dimethylhydrazine-induced colon cancer. Mal
PMID 26264073

A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.

Buchert M1, Rohde F2, Eissmann M3, Tebbutt N4, Williams B5, Tan CW5, Owen A4, Hirokawa Y5, Gnann A2, Orend G6, Orner G7, Dashwood RH8, Heath JK5, Ernst M3, Janssen KP9.
Disease models & mechanisms.Dis Model Mech.2015 Nov 1;8(11):1361-73. doi: 10.1242/dmm.019844. Epub 2015 Aug 6.
Activation of the Wnt/β-catenin pathway occurs in the vast majority of colorectal cancers. However, the outcome of the disease varies markedly from individual to individual, even within the same tumor stage. This heterogeneity is governed to a great extent by the genetic make-up of individual tumor
PMID 26398937

A Simple Device to Rapidly Prepare Whole Mounts of the Mouse Intestine.

Yoneda M1, Molinolo AA2, Ward JM3, Kimura S4, Goodlad RA5.
Journal of visualized experiments : JoVE.J Vis Exp.2015 Oct 27;(105). doi: 10.3791/53042.
Preparing whole mounts of the mouse small intestine and colon for subsequent analysis or quantification can be time consuming and difficult. We describe the use of a simple device to cut and 'roll' mouse intestines to rapidly prepare whole mount preparations of superior and uniform quality to that w
PMID 26556642

Japanese Journal

大麦若葉末摂取による1,2-dimethylhydrazine誘発マウス異型陰窩巣(ACF)の抑制効果

ルミナコイド研究 : 日本食物繊維学会会誌 21(1), 9-18, 2017-06
NAID 40021263798

メトホルミンによる大腸腫瘍の新規予防法開発への取り組み

横浜医学 = Yokohama Medical Journal 68(1・2), 35-46, 2017-05-30
NAID 120006334572

Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice

Journal of Oleo Science 66(2), 157-160, 2017
NAID 130005306145

Related Pictures

★リンクテーブル★

リンク元	「ACF」「大腸異常腺窩」
関連記事	「aberrant」「foci」「cry」

「ACF」

　　[★]

大腸異常腺・

関: aberrant crypt foci

「大腸異常腺窩」

　　[★]

英: aberrant crypt foci、ACF

「aberrant」

　　[★]

ab 'away, from' + errare 'to stray' -> aberrant 'wandering away'

adj.

正道をはずれた、軌道を逸した。あやまった。(生)異常型の。(医)異所性の、迷入性の

Autosomal dominant dRTA results from mutations involving the chloride-bicarbonate exchanger AE1, the gateway for bicarbonate exit into the blood. Anion exchange by the mutant AE1 is normal, but aberrant targeting of AE1 from the basal to apical plasma membrane is believed to cause bicarbonate loss into the urine instead of recovery.(HIM.1085)