WordNet

the readily stainable substance of a cell nucleus consisting of DNA and RNA and various proteins; during mitotic division it condenses into chromosomes (同)chromatin granule
the 24th letter of the Roman alphabet (同)x, ex

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Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B.

Hannah J1, Zhou P2.
Gene.Gene.2015 Nov 15;573(1):33-45. doi: 10.1016/j.gene.2015.08.064. Epub 2015 Sep 3.
The cullin 4 subfamily of genes includes CUL4A and CUL4B, which share a mostly identical amino acid sequence aside from the elongated N-terminal region in CUL4B. Both act as scaffolding proteins for modular cullin RING ligase 4 (CRL4) complexes which promote the ubiquitination of a variety of substr
PMID 26344709

Omega-3 DHA- and EPA-dopamine conjugates induce PPARγ-dependent breast cancer cell death through autophagy and apoptosis.

Rovito D1, Giordano C1, Plastina P1, Barone I2, De Amicis F2, Mauro L1, Rizza P1, Lanzino M2, Catalano S2, Bonofiglio D3, Andò S4.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Nov;1850(11):2185-95. doi: 10.1016/j.bbagen.2015.08.004. Epub 2015 Aug 11.
BACKGROUND: The omega-3 docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) may form conjugates with amines that have potential health benefits against common diseases including cancers. Here we synthesized DHA-dopamine (DHADA) and EPA-dopamine (EPADA) conjugates and studied their biological
PMID 26272430

Rett syndrome: disruption of epigenetic control of postnatal neurological functions.

Pohodich AE1, Zoghbi HY2.
Human molecular genetics.Hum Mol Genet.2015 Oct 15;24(R1):R10-6. doi: 10.1093/hmg/ddv217. Epub 2015 Jun 9.
Loss-of-function mutations in the X-linked gene Methyl-CpG-binding protein 2 (MECP2) cause a devastating pediatric neurological disorder called Rett syndrome. In males, these mutations typically result in severe neonatal encephalopathy and early lethality. On the other hand, owing to expression of t
PMID 26060191

Regulatory genomic regions active in immune cell types explain a large proportion of the genetic risk of multiple sclerosis

The N-terminus and Tudor domains of Sgf29 are important for its heterochromatin boundary formation function

Induction of apoptosis associated with chromosomal DNA fragmentation and caspase-3 activation in leukemia L1210 cells by TiO_2 nanoparticles(MISCELLANEOUS)

Takaki Keiko,Higuchi Yoshihiro,Hashii Minako,Ogino Chiaki,Shimizu Nobuaki
Journal of bioscience and bioengineering 117(1), 129-133, 2014-01
… Chromatin condensation, which is typical of the initiation of cell death, was observed in approximately 14% cells cultured with titanium dioxide (TiO_2) particles for 12 h. …
NAID 110009766616