WSXWS motif

WSXWS構造

WordNet

1. a design or figure that consists of recurring shapes or colors, as in architecture or decoration (同)motive
2. a theme that is repeated or elaborated in a piece of music (同)motive

PrepTutorEJDIC

1. モチーフ / 文学・芸術作品の表現の中心となる主題 / 楽曲の主題 / デザインなどに繰り返して用いられる主模様
2. 気のきいた言葉

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• 1. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
• 2. von Willebrand因子の生物学および正常機能 biology and normal function of von willebrand factor
• 3. Pathophysiology of acquired TTP and other primary thrombotic microangiopathies (TMAs)
• 4. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
• 5. 慢性B型肝炎ウイルス感染に対するラミブジン単剤療法 lamivudine monotherapy for chronic hepatitis b virus infection

English Journal

• A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane.

• Siupka P1, Hamming OT1, Kang L2, Gad HH1, Hartmann R1.
• Genes and immunity.Genes Immun.2015 Jun 4. doi: 10.1038/gene.2015.22. [Epub ahead of print]
• Interleukin-21 (IL-21) is a class I cytokine that belongs to the γc-subfamily of cytokines and regulates immune responses. It signals through a heterodimeric receptor complex composed of the IL-21R1 and γc-receptor chains. A characteristic feature of class I cytokine receptors is the presence of a
• PMID 26043171

• Effect of SXWS/WSXWS peptides on chemotaxis and adhesion of the macrophage-like cell line J774.

• Szabó R1, Láng O, Láng J, Illyés E, Kőhidai L, Hudecz F.
• Journal of molecular recognition : JMR.J Mol Recognit.2015 Apr;28(4):253-60. doi: 10.1002/jmr.2439. Epub 2015 Feb 12.
• WSXWS motif is a conserved amino acid sequence that is present in type I cytokine receptors. This motif that can be found both in the ligand binding chains and signal transducer molecule of the receptors with different amino acids at the position "X" plays a role in the receptor folding, ligand bind
• PMID 25683456

• Molecular and functional characterization of erythropoietin receptor of the goldfish (Carassius auratus L.).

• Katakura F1, Katzenback BA1, Belosevic M2.
• Developmental and comparative immunology.Dev Comp Immunol.2014 Aug;45(2):191-8. doi: 10.1016/j.dci.2014.02.017. Epub 2014 Mar 19.
• Erythropoietin receptor (EPOR) is a member of the class I cytokine receptor superfamily and signaling through this receptor is important for the proliferation, differentiation and survival of erythrocyte progenitor cells. This study reports on the molecular and functional characterization of goldfis
• PMID 24657210

Japanese Journal

• Cloning and Expression of a cDNA Encoding a Prolactin Receptor of the Japanese Red-Bellied Newt, Cynops pyrrhogaster(Endocrinology)

• Yamamoto Takashi,Nakayama Yuki,Matsuda Yoshiko [他],Abe Shin-ichi
• Zoological science 15(5), 741-747, 1998-10-15
• … The extracellular domain had two pairs of cysteine residues and a WSXWS motif. …
• NAID 110003369547

• The role of the WSXWS equivalent motif in growth hormone receptor function

• BAUMGARTNER J. W.
• J Biol Chem 269, 29094-29101, 1994
• NAID 80007969243

• Three Different cDNAs Encoding Mouse D-Factor/LIF Receptor.

• Tomida Mikio,Yamamoto-Yamaguchi Yuri,Hozumi Motoo
• The Journal of Biochemistry 115(3), 557-562, 1994
• … The WSXWS motif found in members of the cytokine receptor family was also present in the extracellular domain of the mouse D-factor receptor. …
• NAID 130003532096

Related Links

• WSXWS motif (Cytokines & Cells Encyclopedia - COPE)

COPE Homepage Bottom of page Previous entry: WSX-1 Next entry: WT1 Random entry: monocytic cells Search COPE: If you find COPE helpful, please show your appreciation by donating what you can afford. WSXWS motif see: Cytokine receptor families

• CSF 受容体及び代謝型グルタミン酸受容体のリガンド認識機構 ...

WSXWS モチーフと，ジスルフィド結合を形成す る保存された4つのシステイン残基を含む領域を共 通にもっており，この領域はサイトカイン受容体相 同領域（Cytokine Receptor Homologous Region） と呼ばれる．主に造血系や免疫系の ...

• The WSXWS motif in cytokine receptors is a molecular switch ...

1. Structure. 2012 Feb 8;20(2):270-82. doi: 10.1016/j.str.2011.12.010. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor. Dagil R, Knudsen ...

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「WSXWS構造」

「WSXWS構造」

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英

WSXWS motif

関

エリスロポエチン受容体