Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/27 07:24:03」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 幼児および小児の孤立性心室中隔欠損のマネージメント management of isolated ventricular septal defects in infants and children
2. 三尖弁（TV）閉鎖症 tricuspid valve tv atresia
3. L型大血管転位 l transposition of the great arteries
4. 総動脈幹 truncus arteriosus
5. 幼児および小児における孤立性心室中隔欠損の病態生理および臨床的特徴 pathophysiology and clinical features of isolated ventricular septal defects in infants and children

English Journal

Outcome and requirement for surgical repair following prenatal diagnosis of ventricular septal defect.

Mosimann B, Zidere V, Simpson JM, Allan LD.Author information Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London, SE5 9RS.AbstractOBJECTIVE: The aims of our study were to document outcome following prenatal diagnosis of VSD, particularly associated anomalies and the requirement for surgical closure of the defect.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.Ultrasound Obstet Gynecol.2013 Dec 19. doi: 10.1002/uog.13284. [Epub ahead of print]
OBJECTIVE: The aims of our study were to document outcome following prenatal diagnosis of VSD, particularly associated anomalies and the requirement for surgical closure of the defect.METHODS: In the period 2002 to end 2011, all cases of prenatal diagnosis of a ventricular septal defect (VSD) made b
PMID 24357326

Omega currents in voltage-gated ion channels: what can we learn from uncovering the voltage-sensing mechanism using MD simulations?

Tarek M, Delemotte L.Author information Université de Lorraine, Equipe Théorie-Modélisation-Simulations, SRSMC, UMR 7565, Vandoeuvre les Nancy, France, and CNRS, Equipe Théorie-Modélisation-Simulations, UMR 7565, Vandoeuvre les Nancy, France.AbstractIon channels conduct charged species through otherwise impermeable biological membranes. Their activity supports a number of physiological processes, and genetic mutations can disrupt their function dramatically. Among these channels, voltage gated cation channels (VGCCs) are ubiquitous transmembrane proteins involved in electrical signaling. In addition to their selectivity for ions, their function requires membrane-polarization-dependent gating. Triggered by changes in the transmembrane voltage, the activation and deactivation of VGCCs proceed through a sensing mechanism that prompts motion of conserved positively charged (basic) residues within the S4 helix of a four-helix bundle, the voltage sensor domain (VSD). Decades of experimental investigations, using electrophysiology, molecular biology, pharmacology, and spectroscopy, have revealed details about the function of VGCCs. However, in 2005, the resolution of the crystal structure of the activated state of one member of the mammalian voltage gated potassium (Kv) channels family (the Kv1.2) enabled researchers to make significant progress in understanding the structure-function relationship in these proteins on a molecular level. In this Account, we review the use of a complementary technique, molecular dynamics (MD) simulations, that has offered new insights on this timely issue. Starting from the "open-activated state" crystal structure, we have carried out large-scale all atom MD simulations of the Kv1.2 channel embedded in its lipidic environment and submitted to a hyperpolarizing (negative) transmembrane potential. We then used steered MD simulations to complete the full transition to the resting-closed state. Using these procedures, we have followed the operation of the VSDs and uncovered three intermediate states between their activated and deactivated conformations. Each conformational state is characterized by its network of salt bridges and by the occupation of the gating charge transfer center by a specific S4 basic residue. Overall, the global deactivation mechanism that we have uncovered agrees with proposed kinetic models and recent experimental results that point towards the presence of several intermediate states. The understanding of these conformations has allowed us to examine how mutations of the S4 basic residues analogous to those involved in genetic diseases affect the function of VGCCs. In agreement with electrophysiology experiments, mutations perturb the VSD structure and trigger the appearance of state-dependent "leak" currents. The simulation results unveil the key elementary molecular processes involved in these so-called "omega" currents. We generalize these observations to other members of the VGCC family, indicating which type of residues may generate such currents and which conditions might cause leaks that prevent proper function of the channel. Today, the understanding of the intermediate state conformations enables researchers to confidently tackle other key questions such as the mode of action of toxins or modulation of channel function by lipids.
Accounts of chemical research.Acc Chem Res.2013 Dec 17;46(12):2755-62. doi: 10.1021/ar300290u. Epub 2013 May 22.
Ion channels conduct charged species through otherwise impermeable biological membranes. Their activity supports a number of physiological processes, and genetic mutations can disrupt their function dramatically. Among these channels, voltage gated cation channels (VGCCs) are ubiquitous transmembran
PMID 23697886

Rhythm and conduction abnormalities after transcatheter closure of VSDs: A single-center experience.

Erdem S, Ozbarlas N, Kızıltaş A, Bozkurt A, Küçükosmanoğlu O.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology.Anadolu Kardiyol Derg.2013 Dec 9. doi: 10.5152/akd.2013.4538. [Epub ahead of print]
PMID 24342005

Japanese Journal

化学物質の健康影響に関する基準値等の設定方法と最近の国際動向

広瀬明彦
保健物理 : hoken buturi 44(3), 294-303, 2009-09
… The procedures and current trends of guidance value setting, such as TDIs or VSDs, for human health effects by chemical exposure was summarized in this article. …
NAID 110007467656

0407 M-PAC大型モータ駆動圧縮機設備(S73 安全のための新技術,S73 安全のための新技術)

島川司
年次大会講演論文集 : JSME annual meeting 2007(5), 89-90, 2007-09-07
This paper describes the characteristic of M-PAC, large Motor driven Compressor train for Chemical plant. Motor driven Compressor train which be required the high trustworthy shall introduce based on …
NAID 110007084921

Optical Bioimaging : From Living Tissue to a Single Molecule : Optical Detection of Synaptically Induced Glutamate Transporter Activity in Hippocampal Slices

Nakamura Takeshi,Kawamura Yoshinobu,Miyakawa Hiroyoshi
Journal of pharmacological sciences 93(3), 234-241, 2003-11-01
… Since voltage-sensitive dyes (VSDs) change their optical properties in response to membrane potential changes, non-invasive optical measurements of membrane excitation using VSDs have been applied to various types of excitable tissue. …
NAID 130000073911

Related Pictures

VSDs page banner VSDS-34005 VSDs on dredger: CASIO G-SHOCK ジーショックカシオ VSDS Terminal PS100N $150~$250 środa, 06 czerwca 2012 08:32 psp vs ds Click to enlarge vsds5.jpg