- 関
- synaptobrevin 1、VAMP-1、vesicle-associated membrane protein 1
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/27 16:16:19」(JST)
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Vesicle-associated membrane protein 1 (synaptobrevin 1) |
PDB rendering based on 1kil.
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Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1kil, 1n7s
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Identifiers |
Symbols |
VAMP1 ; SPAX1; SYB1; VAMP-1 |
External IDs |
OMIM: 185880 MGI: 1313276 HomoloGene: 40678 ChEMBL: 2038 GeneCards: VAMP1 Gene |
Gene ontology |
Molecular function |
• SNARE binding
• SNAP receptor activity
• protein binding
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Cellular component |
• mitochondrial outer membrane
• cytosol
• integral component of plasma membrane
• synaptic vesicle
• cell surface
• cell junction
• synaptic vesicle membrane
• SNARE complex
• azurophil granule membrane
• specific granule membrane
• terminal bouton
• tertiary granule membrane
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Biological process |
• exocytosis
• vesicle fusion
• synaptic transmission
• SNARE complex assembly
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
6843 |
22317 |
Ensembl |
ENSG00000139190 |
ENSMUSG00000030337 |
UniProt |
P23763 |
Q62442 |
RefSeq (mRNA) |
NM_001297438 |
NM_001080557 |
RefSeq (protein) |
NP_001284367 |
NP_001074026 |
Location (UCSC) |
Chr 12:
6.46 – 6.47 Mb |
Chr 6:
125.22 – 125.24 Mb |
PubMed search |
[1] |
[2] |
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Vesicle-associated membrane protein 1 is a protein that in humans is encoded by the VAMP1 gene.[1][2]
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.[2]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
[[File:
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
File:NicotineDopaminergic_WP1602.png
Nicotine Activity on Dopaminergic Neurons edit
- ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".
References
- ^ Archer BT 3rd, Ozcelik T, Jahn R, Francke U, Sudhof TC (Nov 1990). "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2". J Biol Chem 265 (28): 17267–73. PMID 1976629.
- ^ a b "Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)".
Further reading
- Ravichandran V, Chawla A, Roche PA (1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues.". J. Biol. Chem. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
- Jagadish MN, Fernandez CS, Hewish DR et al. (1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.". Biochem. J. 317. ( Pt 3): 945–54. PMC 1217577. PMID 8760387.
- Annaert WG, Becker B, Kistner U et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31.". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.
- Weir ML, Klip A, Trimble WS (1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.". Biochem. J. 333. ( Pt 2): 247–51. PMC 1219579. PMID 9657962.
- Isenmann S, Khew-Goodall Y, Gamble J et al. (1999). "A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal.". Mol. Biol. Cell 9 (7): 1649–60. doi:10.1091/mbc.9.7.1649. PMC 25402. PMID 9658161.
- Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
- Berglund L, Hoffmann HJ, Dahl R, Petersen TE (1999). "VAMP-1 has a highly variable C-terminus generated by alternative splicing.". Biochem. Biophys. Res. Commun. 264 (3): 777–80. doi:10.1006/bbrc.1999.1588. PMID 10544008.
- Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay.". Mol. Cell. Neurosci. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Imabayashi H, Mori T, Gojo S et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
PDB gallery
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1kil: Three-dimensional structure of the complexin/SNARE complex
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1n7s: High Resolution Structure of a Truncated Neuronal SNARE Complex
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English Journal
- TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.
- Meng J1,2, Wang J1, Steinhoff M2, Dolly JO1.
- Scientific reports.Sci Rep.2016 Feb 18;6:21226. doi: 10.1038/srep21226.
- Transient receptor potential (TRP) A1 and V1 channels relay sensory signals, yet little is known about their transport to the plasmalemma during inflammation. Herein, TRPA1 and TRPV1 were found on vesicles containing calcitonin gene-related peptide (CGRP), accumulated at sites of exo- and endo-cytos
- PMID 26888187
- SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond.
- Cupertino RB1, Kappel DB1, Bandeira CE1, Schuch JB1, da Silva BS1, Müller D1, Bau CH2, Mota NR1.
- Journal of neural transmission (Vienna, Austria : 1996).J Neural Transm (Vienna).2016 Feb 8. [Epub ahead of print]
- Multiple biological processes throughout development require intracellular vesicular trafficking, where the SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors) complex plays a major role. The core proteins forming the SNARE complex are SNAP-25 (synaptosomal-as
- PMID 26856328
- Erratum to: Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility.
- Sevlever D1, Zou F1,2, Ma L1, Carrasquillo S1, Crump MG1, Culley OJ1, Hunter TA1, Bisceglio GD1, Younkin L1, Allen M1, Carrasquillo MM1, Sando SB3,4, Aasly JO4, Dickson DW1, Graff-Radford NR5, Petersen RC6, Deák F1,7; Kevin Morgan for ARUK consortium, Belbin O8,9.
- Molecular neurodegeneration.Mol Neurodegener.2015 Sep 23;10:49. doi: 10.1186/s13024-015-0047-2.
- Following publication of this work, we noticed that we inadvertently failed to include Dr Ferenc Deák in the author list. The author list has now been corrected and the amended authors' contributions section has been modified accordingly below.
- PMID 26399695
Japanese Journal
- An insertion of intracisternal A-particle retrotransposon in a novel member of the phosphoglycerate mutase family in the lew allele of mutant mice
Related Links
- Interactive pathway map References Further reading, Vamp1, Vamp1, vamp 1, Weird australian vamp # 1, vamp1, Ten Year Vamp's #1 Fan, Brenda, Gets Excited!, Julie London Documentary: The Lady's Not A Vamp - 1/6, Blues ...
- Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane.
Related Pictures
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[★]
シナプトブレビン1
- 関
- VAMP-1、VAMP1、vesicle-associated membrane protein 1
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- 英
- vesicle-associated membrane protein 1、VAMP1
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- シナプトブレビン1
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小胞結合膜タンパク質1
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- synaptobrevin 1、VAMP-1、VAMP1