English Journal

Morphine inhibits sleep-promoting neurons in the ventrolateral preoptic area via mu receptors and induces wakefulness in rats.

Wang Q, Yue XF, Qu WM, Tan R, Zheng P, Urade Y, Huang ZL.SourceState Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.Neuropsychopharmacology.2013 Apr;38(5):791-801. doi: 10.1038/npp.2012.244. Epub 2012 Nov 30.
Morphine is the most efficacious and widely prescribed treatment for pain. However, it decreases the total amount of deep sleep and rapid eye movement sleep in humans. Acute morphine administration at low doses causes wakefulness in animal models. To clarify the mechanism by which morphine affects s
PMID 23303062

κ-Opioid receptor stimulation modulates TLR4/NF-κB signaling in the rat heart subjected to ischemia-reperfusion.

Lin J, Wang H, Li J, Wang Q, Zhang S, Feng N, Fan R, Pei J.SourceDepartment of Physiology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an, 710032 Shaanxi Province, PR China.
Cytokine.Cytokine.2013 Mar;61(3):842-8. doi: 10.1016/j.cyto.2013.01.002. Epub 2013 Feb 10.
It is well documented that the Toll-like receptor 4 (TLR4)/NF-κB signaling mediates early inflammation during myocardial ischemia and reperfusion. Our previous study has demonstrated that κ-opioid receptor stimulation with U50,488H produces cardioprotective and anti-inflammatory effects. The aim o
PMID 23402995

Ultralow dose fentanyl prevents development of chronic neuropathic pain in rats.

Wala EP, Holtman JR, Sloan PA.SourceDepartment of Anesthesiology, University of Kentucky, Lexington, KY, USA.
Journal of opioid management.J Opioid Manag.2013 Mar-Apr;9(2):85-96. doi: 10.5055/jom.2013.0150.
BACKGROUND: Opioids may cause progressive enhancement of pain sensitivity (opioid-induced hyperalgesia [OIH]) and thus, exacerbate existing pain. Animal studies also demonstrate paradoxical OIH with an ultralow dose (ULD, subanalgesic) of opioid; eg, the μ-opioid, morphine. Repeated administration
PMID 23709318

Japanese Journal

オピオイドレセプターの情報伝達系による脱感作の違い

金子周司,矢田宜道,足立圭,赤池昭紀,佐藤公道
日本薬理学雑誌 106, 147-151, 1995-09-01
… and β subunits, the κ agonist U50488H (1 μM) inhibited Ca<SUP>2+</SUP> … for U50488H-induced inhibition of BIII- or N-type channels was only 6±1 min. Moreover, in the oocytes expressing κ opioid receptor, EP<SUB>4</SUB> … even when the oocytes were treated with U50488H for 2 hours or more. …
NAID 10008631388

Pharmacology of the spinal action of ketrolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and in isobolographic analysis of the NSAID interaction

MALMBERG AB.
Anesthesiologly 79, 270-281, 1993
NAID 30009141844

オピオイドレセプターアゴニストによる鎮痛効果の検討:MSU-testを用いて

奥達也,我妻恭行,大槻泰介,桜田忍,桜田司,木皿憲佐,城倉英史,吉本高志
PAIN RESEARCH 6(2), 95-97, 1991
NAID 130004651950

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