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- thromboxane B2
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/05 18:55:31」(JST)
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Thromboxane B2
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Identifiers |
CAS Registry Number
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54397-85-2 |
ChEBI |
CHEBI:28728 |
Jmol-3D images |
Image |
MeSH |
Thromboxane+B2 |
PubChem |
5283137 |
SMILES
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CCCCC[C@H](O)\C=C\[C@H]1OC(O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
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Properties |
Chemical formula
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C20H34O6 |
Molar mass |
370.48 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Y verify (what is: Y/N?) |
Infobox references |
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Thromboxane B2 is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine.
It itself is not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is. Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). [1]
2-(3,4-Di-hydroxyphenyl)-ethanol (DHPE) is a phenolic component of extra-virgin olive oil. An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro.[2]
References
- ^ "Definition: thromboxane b2 from Online Medical Dictionary". Retrieved 2008-11-02.
- ^ Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Anna Petroni, Milena Blasevich, Marco Salami, Nadia Papini, Gian F. Montedoro and Claudio Gallia, Thrombosis Research, 15 April 1995, Volume 78, Issue 2, Pages 151–160, doi:10.1016/0049-3848(95)00043-7
Eicosanoids
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Precursor |
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Prostanoids |
Prostaglandins (PG) |
Precursor |
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Active |
D/J |
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E/F |
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I |
- I2 (Prostacyclin/Epoprostenol):
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Thromboxanes (TX) |
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Leukotrienes (LT) |
Precursor |
- Arachidonic acid 5-hydroperoxide
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Initial |
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SRS-A |
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Eoxins (EX) |
Precursor |
- Arachidonic acid 15-hydroperoxide
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Eoxins |
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Nonclassic |
- Lipoxins (LX) (A4, B4)
- Virodhamine
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By function |
- vasoconstriction
- vasodilation
- platelets: induce
- inhibit
- leukocytes: induce
- inhibit
- labor stimulation:
- PGE2 (Dinoprostone)
- PGF2α (Dinoprost)
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Index of inborn errors of metabolism
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Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
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Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
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Treatment |
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Index of biochemical families
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Carbohydrates |
- Alcohols
- Glycoproteins
- Glycosides
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Lipids |
- Eicosanoids
- Fatty acids
- Glycerides
- Phospholipids
- Sphingolipids
- Steroids
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Nucleic acids |
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Proteins |
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Other |
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UpToDate Contents
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English Journal
- Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment.
- Markworth JF, Vella L, Lingard BS, Tull DL, Rupasinghe TW, Sinclair AJ, Maddipati KR, Cameron-Smith D.SourceSchool of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia;
- American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2013 Dec;305(11):R1281-96. doi: 10.1152/ajpregu.00128.2013. Epub 2013 Oct 2.
- Classical proinflammatory eicosanoids, and more recently discovered lipid mediators with anti-inflammatory and proresolving bioactivity, exert a complex role in the initiation, control, and resolution of inflammation. Using a targeted lipidomics approach, we investigated circulating lipid mediator r
- PMID 24089379
- Factors influencing Multiplate whole blood Impedance Platelet Aggregometry measurements, during aspirin treatment in acute ischemic stroke: a pilot study.
- Jastrzębska M, Chełstowski K, Wódecka A, Siennicka A, Clark J, Nowacki P.SourceaDepartment of Laboratory Diagnostics and Molecular Medicine bDepartment of Neurology; Pomeranian Medical University, Szczecin, Poland.
- Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.Blood Coagul Fibrinolysis.2013 Dec;24(8):830-8. doi: 10.1097/MBC.0b013e3283655640.
- Among patients with stroke, the phenomenon of resistance to treatment with low-dose aspirin acetylsalicylic acid (ASA) is quite common. The study included 133 patients hospitalized with acute ischemic stroke. Impedance platelet aggregometry (IPA) and levels of vWF and thromboxane (TXB2) were assesse
- PMID 24071649
- Study of molecular mechanism of Prostaglandin E1 in inhibiting coronary heart disease.
- Liu HJ, Ma JW, Qiao ZY, Xu B.SourceDepartment of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Shanghai, 201400, China.
- Molecular biology reports.Mol Biol Rep.2013 Dec;40(12):6701-8. doi: 10.1007/s11033-013-2785-y. Epub 2013 Oct 22.
- Prostaglandin E1 has been used clinically for improving heart diseases. In this study, we examined the effect of Prostaglandin E1 on blood lipid levels, heart protein and genes expression in coronary heart disease (CHD) rats. Female rats were fed either a control diet or hypercholesterolemic diet fo
- PMID 24146100
Japanese Journal
- Influence of Nonsteroidal Anti-inflammatory Drugs on the Antiplatelet Effects of Aspirin in Rats
- Akagi Yuuki,Nio Yuta,Shimada Shuji,Aoyama Takao
- Biological & Pharmaceutical Bulletin 34(2), 233-237, 2011
- … Platelet aggregation (ADP and collagen were added as stimuli) and serum thromboxane B2 (TXB2) concentrations were measured. … In contrast, serum TXB2 concentrations in all groups were lower than those in the control group (drug-free). …
- NAID 130000402195
- トロンボキサンA2(TXA2),トロンボキサンB2(TXB2) (広範囲 血液・尿化学検査 免疫学的検査(第7版・4)その数値をどう読むか) -- (プロスタノイド,サイトカイン,増殖因子,ケモカイン)
Related Links
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- 名称(別名) トロンボキサン類(Thromboxans, TX) TXA2 TXB2 構 造・性 質 基本骨格:トロンバン酸(Thrombanoic acid)。 TXA:9-11 epoxide,15-OH TXB:9,11,15-OH 生産部位・分 布 血小板、肺、脾、脳 ...
Related Pictures
★リンクテーブル★
[★]
トロンボキサンB2
- 関
- TXB2
[★]
- 英
- thromboxane B2、TXB2
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