- 同
- TRAFs
- 同
- TRAFs
WordNet
- having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
- a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
- a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
- any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
- make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- the 20th letter of the Roman alphabet (同)t
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- tritiumの化学記号
- =sense organ / 受信装置
UpToDate Contents
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English Journal
- CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile.
- Sierra-Filardi E1, Nieto C, Domínguez-Soto A, Barroso R, Sánchez-Mateos P, Puig-Kroger A, López-Bravo M, Joven J, Ardavín C, Rodríguez-Fernández JL, Sánchez-Torres C, Mellado M, Corbí AL.Author information 1Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain;AbstractThe CCL2 chemokine mediates monocyte egress from bone marrow and recruitment into inflamed tissues through interaction with the CCR2 chemokine receptor, and its expression is upregulated by proinflammatory cytokines. Analysis of the gene expression profile in GM-CSF- and M-CSF-polarized macrophages revealed that a high CCL2 expression characterizes macrophages generated under the influence of M-CSF, whereas CCR2 is expressed only by GM-CSF-polarized macrophages. Analysis of the factors responsible for this differential expression identified activin A as a critical factor controlling the expression of the CCL2/CCR2 pair in macrophages, as activin A increased CCR2 expression but inhibited the acquisition of CCL2 expression by M-CSF-polarized macrophages. CCL2 and CCR2 were found to determine the extent of macrophage polarization because CCL2 enhances the LPS-induced production of IL-10, whereas CCL2 blockade leads to enhanced expression of M1 polarization-associated genes and cytokines, and diminished expression of M2-associated markers in human macrophages. Along the same line, Ccr2-deficient bone marrow-derived murine macrophages displayed an M1-skewed polarization profile at the transcriptomic level and exhibited a significantly higher expression of proinflammatory cytokines (TNF-α, IL-6) in response to LPS. Therefore, the CCL2-CCR2 axis regulates macrophage polarization by influencing the expression of functionally relevant and polarization-associated genes and downmodulating proinflammatory cytokine production.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Apr 15;192(8):3858-67. doi: 10.4049/jimmunol.1302821. Epub 2014 Mar 17.
- The CCL2 chemokine mediates monocyte egress from bone marrow and recruitment into inflamed tissues through interaction with the CCR2 chemokine receptor, and its expression is upregulated by proinflammatory cytokines. Analysis of the gene expression profile in GM-CSF- and M-CSF-polarized macrophages
- PMID 24639350
- Systemic inflammation and brachial artery endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA).
- Weiner SD1, Ahmed HN, Jin Z, Cushman M, Herrington DM, Nelson JC, Di Tullio MR, Homma S.Collaborators (1)Saad MF.
- Heart (British Cardiac Society).Heart.2014 Apr 8. doi: 10.1136/heartjnl-2013-304893. [Epub ahead of print]
- BACKGROUND AND OBJECTIVE: Inflammation and endothelial dysfunction have been implicated in the pathogenesis of atherosclerotic vascular disease. Brachial artery flow-mediated dilation (FMD) is a reliable, non-invasive method of assessing endothelial function. We hypothesised that increased levels of
- PMID 24714919
- Cell biology. RIPK3 takes another deadly turn.
- Zhang J1, Chan FK.
- Science (New York, N.Y.).Science.2014 Mar 21;343(6177):1322-3. doi: 10.1126/science.1252526.
- PMID 24653026
Japanese Journal
- TNF Receptor-Associated Factor (TRAF) Signaling Network in CD4<sup>+</sup> T-Lymphocytes
- 腱の状態によるTNFαとTNF-R1を介する細胞内シグナル伝達因子の分布と発現の差違(解剖学)
- The journal of veterinary medical science 67(10), 985-991, 2005-10-25
- NAID 110003983117
- Distribution of TNF receptors and TNF receptor-associated intracellular signaling factors on equine tendinocytes in vitro
Related Links
- 1. Oncogene. 2001 Oct 1;20(44):6482-91. Tumor necrosis factor receptor-associated factors (TRAFs). Bradley JR(1), Pober JS. Author information: (1)Department of Medicine, University of Cambridge School of Clinical ...
- Tumor necrosis factor receptor-associated factors (TRAFS) were initially discovered as adaptor proteins that couple the tumor necrosis factor receptor family to signaling pathways. More recently they have also been ...
- It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor
★リンクテーブル★
[★]
- 結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる
- 仲間/友人などとして交際する(with)。一つにまとめる、連合する
- 仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
- 密接な蒸す偽付きのある物、付随する物、つきもの。準国家
- 連想によって心に浮かぶ言葉/思い、連想物
- 仲間の、同僚の。製紙機械員に次ぐ資格の
- 付随する、連想される
- 関
- accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union
[★]
- 関
- TNFR、tumor necrosis factor receptor
[★]
- 関
- element、elementary、factorial、parameter
[★]
[★]
- 関
- concomitant、erratic、erratically
- associate