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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/05 05:05:31」(JST)
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general transcription factor IIF, polypeptide 1, 74kDa |
Identifiers |
Symbol |
GTF2F1 |
Alt. symbols |
TFIIF, BTF4, RAP74 |
Entrez |
2962 |
HUGO |
4652 |
OMIM |
189968 |
RefSeq |
NM_002096 |
UniProt |
P35269 |
Other data |
Locus |
Chr. 19 p13.3 |
general transcription factor IIF, polypeptide 2, 30kDa |
Identifiers |
Symbol |
GTF2F2 |
Alt. symbols |
TFIIF, BTF4, RAP30 |
Entrez |
2963 |
HUGO |
4653 |
OMIM |
189969 |
RefSeq |
NM_004128 |
UniProt |
P13984 |
Other data |
Locus |
Chr. 13 q14 |
general transcription factor IIF, polypeptide 2-like |
Identifiers |
Symbol |
GTF2F2L |
Alt. symbols |
TFIIF |
Entrez |
2964 |
HUGO |
4654 |
RefSeq |
NG_003013 |
Other data |
Locus |
Chr. 4 q31.22 |
Transcription factor IIF (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1][2][3]
Transcription Factor IIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes.[4][5][6]
TFIIF binds to RNA PolII when the enzyme is already unbound to any other transcription factor, thus avoiding it from contacting DNA outside the promoter. Furthermore, TFIIF stabilizes the RNA polymerase II while it's contacting TBP and TFIIB.
See also
- TFIIA
- TFIIB
- TFIID
- TFIIE
- TFIIH
References
- ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636–637. ISBN 0-13-144946-X.
- ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
- ^ Kim TK, Lagrange T, Wang YH, Griffith JD, Reinberg D, Ebright RH (1997). "Trajectory of DNA in the RNA polymerase II transcription preinitiation complex". Proc Natl Acad Sci USA 94 (23): 12268–73. doi:10.1073/pnas.94.23.12268. PMC 24903. PMID 9356438.
- ^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature 355 (6359): 464–7. doi:10.1038/355464a0. PMID 1734284.
- ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
- ^ Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH (1995). "Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens". Cytogenet. Cell Genet. 69 (1-2): 75–80. doi:10.1159/000133942. PMID 7835093.
External links
- Transcription Factor TFIIF at the US National Library of Medicine Medical Subject Headings (MeSH)
Cell physiology: Cell signaling / Signal transduction
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Signaling pathways |
- GPCR
- RTK
- Notch
- JAK-STAT
- Akt/PKB
- Fas apoptosis
- Hippo
- PI3K/AKT/mTOR pathway
- Integrin receptors
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Agents |
Receptor ligands |
- Hormones
- Neurotransmitters/Neuropeptides/Neurohormones
- Cytokines
- Growth factors
- Signaling molecules
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Receptors |
- Cell surface
- Intracellular
- Co-receptor
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Second messenger |
- cAMP-dependent pathway
- Ca2+ signaling
- Lipid signaling
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Assistants: |
- Signal transducing adaptor protein
- Scaffold protein
|
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Transcription factors |
- General
- Transcription preinitiation complex
- TFIID
- TFIIH
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By distance |
- Juxtacrine
- Autocrine / Paracrine
- Endocrine
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Other concepts |
- Intracrine action
- Neurocrine signaling
- Synaptic transmission
- Chemical synapse
- Neuroendocrine signaling
- Exocrine signalling
- Mechanotransduction
- Phototransduction
- Ion channel gating
- Gap junction
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Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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English Journal
- Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
- Barnes CO1, Calero M2, Malik I3, Graham BW4, Spahr H5, Lin G2, Cohen AE6, Brown IS2, Zhang Q2, Pullara F7, Trakselis MA8, Kaplan CD3, Calero G9.
- Molecular cell.Mol Cell.2015 Jul 16;59(2):258-69. doi: 10.1016/j.molcel.2015.06.034.
- Notwithstanding numerous published structures of RNA Polymerase II (Pol II), structural details of Pol II engaging a complete nucleic acid scaffold have been lacking. Here, we report the structures of TFIIF-stabilized transcribing Pol II complexes, revealing the upstream duplex and full transcriptio
- PMID 26186291
- Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element.
- Arimbasseri AG1, Maraia RJ2.
- Molecular cell.Mol Cell.2015 Jun 18;58(6):1124-32. doi: 10.1016/j.molcel.2015.04.002. Epub 2015 May 7.
- Understanding the mechanism of transcription termination by a eukaryotic RNA polymerase (RNAP) has been limited by lack of a characterizable intermediate that reflects transition from an elongation complex to a true termination event. While other multisubunit RNAPs require multipartite cis-signals a
- PMID 25959395
- Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters.
- Mungamuri SK1, Wang S2, Manfredi JJ1, Gu W3, Aaronson SA1.
- Oncogene.Oncogene.2015 May 7;34(19):2461-70. doi: 10.1038/onc.2014.198. Epub 2014 Jul 14.
- Chromatin conformation has a major role in all cellular decisions. We showed previously that P53 pro-apoptotic target promoters are enriched with H3K9me3 mark and induction of P53 abrogates this repressive chromatin conformation by downregulating SUV39H1, the writer of this mark present on these pro
- PMID 25023704
Japanese Journal
- Heterogeneous Nuclear Ribonucleoprotein R Cooperates with Mediator to Facilitate Transcription Reinitiation on the c-Fos Gene
- Mutational analysis of the central part of human RNA polymerase II subunit 5 (RPB5) by two-step alanine scanning: the residues critical for interactions with TFIIF subunit RAP30 and Hepatitis B Virus X protein and those for DNA-binding ability
- Mutational Analysis of Human RNA Polymerase II Subunit 5 (RPB5) : The Residues Critical for Interactions with TFIIF Subunit RAP30 and Hepatitis B Virus X Protein
Related Links
- Structure of Rap74 Subunit Of Human Transcription Factor Iif (Tfiif) C-Terminal Domain Primary citation: Kamada, K., De Angelis, J., Roeder, R. G., Burley, S. K.: Crystal Structure of the C-Terminal Domain of the RAP74 Subunit ...
- 米国CST社の日本法人CSTジャパン株式会社【公式サイト】TFIIF-α Antibodyページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
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