WordNet
- any of various stocky heavy-coated breeds of dogs native to northern regions having pointed muzzles and erect ears with a curled furry tail
PrepTutorEJDIC
- 母斑(ぼはん)(先天性のあざ・ほくろ・そばかすなど)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/03 10:08:02」(JST)
[Wiki en表示]
| Spitz nevus |
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Spitz nevus
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| Classification and external resources |
| Specialty |
Oncology |
| ICD-10 |
D22 (ILDS D22.L32) |
| ICD-O |
M8770/0 |
| DiseasesDB |
29807 |
| eMedicine |
article/1059623 |
| MeSH |
D018332 |
A Spitz nevus (also known as an epithelioid and spindle-cell nevus,[1] benign juvenile melanoma,[1]:691 and "Spitz's juvenile melanoma"[2]) is a benign melanocytic nevus, a type of skin lesion, affecting the epidermis and dermis.[3]
The name juvenile melanoma is generally no longer used as it is misleading: it is not a melanoma, it is a benign lesion; and it can also occur in adults, not only in children.[4]
Contents
- 1 Epidemiology
- 2 Pathology
- 3 Eponym
- 4 See also
- 5 References
Epidemiology
Spitz nevi are uncommon. Their annual incidence was estimated in a coastal population of sub-tropical Queensland to be 1.4 cases per 100,000 people. For comparison, the annual incidence of melanoma in the same population, which is high by world standards[5] is 25.4 cases per 100,000 people.[4]
Although they are most commonly found on people in their first two decades of life,[3] the age range for people with Spitz nevi is from 6 months to 71 years, with a mean age of 22 years and a median age of 19 years.[4]
Pathology
Micrograph of a Spitz nevus showing the characteristic vertically arranged nests of cells ("hanging bananas"). H&E stain.
The cause of Spitz nevi is not yet known. There is an association with sunburn, but causation is not established.[3] Genetic studies of Spitz nevi have shown that most cells have the normal number of chromosomes, however a minority (25%) of cells have been shown to contain extra copies of parts of some chromosomes, such as the short arm of chromosome 11 (11p).[3]
Spitz nevi characteristically have vertically arranged nests of nevus cells that have both a spindled and an epithelioid morphology. Apoptotic cells may be seen at the dermoepidermal junction. The main histologic differential diagnoses are pigmented spindle cell nevus and malignant melanoma.
Eponym
The lesion is named after Sophie Spitz, the pathologist who originally described it in 1948.[6]
See also
- List of cutaneous conditions
- List of genes mutated in pigmented cutaneous lesions
- Melanoma with features of a Spitz nevus
References
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Wikimedia Commons has media related to Spitz nevus. |
- ^ a b James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1728–30. ISBN 1-4160-2999-0.
- ^ a b c d LeBoit, PE, Burg G, Weedon D, Sarasin A. (Eds) World Health Organization Classification of Tumours: Pathology and Genetics of Skin Tumours. Lyon: IARCPress. 2006.
- ^ a b c Crotty, K. Spitz Naevus: Histological features and distinction from malignant melanoma. Australasian Journal of Dermatology. 38 (suppl): S49-S53. 1997.
- ^ Ries LAG, et al., eds. SEER Cancer Statistics Review, 1975–2000. Bethesda, MD: National Cancer Institute; 2003: Tables XVI-1-9.
- ^ Spitz S. Melanomas of childhood. Am. J. Pathol.1948;24:591-609.
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Tumors: Skin neoplasm, Nevi and melanomas (C43/D22, 172/216, ICD-O 8720-8799)
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| Melanoma |
- Mucosal melanoma
- Superficial spreading melanoma
- Nodular melanoma
- lentigo
- Lentigo maligna/Lentigo maligna melanoma
- Acral lentiginous melanoma
- Amelanotic melanoma
- Desmoplastic melanoma
- Melanoma with features of a Spitz nevus
- Melanoma with small nevus-like cells
- Polypoid melanoma
- Nevoid melanoma
- Melanocytic tumors of uncertain malignant potential
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Nevus/
melanocytic nevus |
- Nevus of Ito/Nevus of Ota
- Compound nevus
- Spitz nevus
- Pigmented spindle cell nevus
- Halo nevus
- Junctional nevus
- Pseudomelanoma
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- Blue nevus
- of Jadassohn–Tièche
- Cellular
- Epithelioid
- Deep penetrating
- Amelanotic
- Malignant
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- Congenital melanocytic nevus (Giant
- Medium-sized
- Small-sized)
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- Balloon cell nevus
- Dysplastic nevus/Dysplastic nevus syndrome
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- Acral nevus
- Becker's nevus
- Benign melanocytic nevus
- Nevus spilus
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Index of skin
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| Description |
- Anatomy
- Physiology
- Development
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| Disease |
- Infections
- Vesiculobullous
- Dermatitis and eczema
- Papulosquamous
- Urticaria and erythema
- Radiation-related
- Pigmentation
- Mucinoses
- Keratosis, ulcer, atrophy, and necrobiosis
- Vasculitis
- Fat
- Neutrophilic and eosinophilic
- Congenital
- Neoplasms and cancer
- nevi and melanomas
- epidermis
- dermis
- Symptoms and signs
- Terminology
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| Treatment |
- Procedures
- Drugs
- antibiotics
- disinfectants
- emollients and protectives
- itch
- psoriasis
- other
- Wound and ulcer
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UpToDate Contents
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English Journal
- Solitary spindle cell xanthogranuloma mimicking a spitz nevus.
- Nakamura Y, Nakamura A, Muto M.SourceDepartment of Dermatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
- The American Journal of dermatopathology.Am J Dermatopathol.2013 Dec;35(8):865-7. doi: 10.1097/DAD.0b013e3182840d2d.
- PMID 24257193
- 9p21 gene locus in Spitz nevi of older individuals: absence of cytogenetic and immunohistochemical findings associated with malignancy.
- Horst BA, Terrano D, Fang Y, Silvers DN, Busam KJ.SourceDepartment of Dermatology, Columbia University Medical Center, New York City, NY 10032, USA; Department of Pathology & Cell Biology, Columbia University Medical Center, New York City, NY 10032, USA. Electronic address: bh2179@columbia.edu.
- Human pathology.Hum Pathol.2013 Dec;44(12):2822-8. doi: 10.1016/j.humpath.2013.07.034. Epub 2013 Oct 14.
- The diagnosis of Spitz nevus in an elderly individual is often met with skepticism because the lesion can be difficult to distinguish from melanoma and because the probability of a malignant melanoma is higher in older patients. Recently, increased sensitivity for detection of malignant spitzoid neo
- PMID 24134932
Japanese Journal
- 渡邊 恒輔,福田 英嗣,鈴木 琢 [他]
- 皮膚科の臨床 54(7), 1003-1006,935-936, 2012-07-00
- NAID 40019379646
- 悪性黒色腫との鑑別が困難であった Spitz 母斑の1例
- 八杉 悠,黒川 正人,佐藤 誠,中山 真紀
- Skin cancer : official organ of the Japanese Society for Skin Cancer = 皮膚悪性腫瘍研究会機関誌 26(1), 108-113, 2011-05-20
- … 再度，他施設での病理組織学的診断を依頼し，Spitz母斑の確定診断に至った。 …
- NAID 10030441919
Related Links
- 3 Jan 2012 ... Spitz Nevus. Physicians have known for almost a century that some childhood lesions histologically diagnosed as melanomas did not show malignant behavior.
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