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any of various organs that synthesize substances needed by the body and release it through ducts or directly into the bloodstream (同)secretory organ, secretor, secreter

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(生物体内の)腺(せん)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/05 08:43:07」(JST)

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In female human anatomy, Skene's glands or the Skene glands (/skiːn/; US dict: skēn; also known as the lesser vestibular glands, periurethral glands, paraurethral glands,^[1] or female prostate) are glands located on the anterior wall of the vagina, around the lower end of the urethra. They drain into the urethra and near the urethral opening and may be near or a part of the G-spot. These glands are surrounded with tissue (which includes the part of the clitoris) that reaches up inside the vagina and swells with blood during sexual arousal.

Structure and function

The location of the Skene's gland is the general area of the vulva, glands located on the anterior wall of the vagina around the lower end of the urethra. They are homologous with the prostate gland in males.^[2] The Skene's ducts are a pair of ducts leading from the Skene's glands to the surface of the vulva, to the left and right of the urethral opening.

It has been postulated that the Skene's glands are the source of female ejaculation.^[3] Female ejaculate, which may emerge during sexual activity for some women, especially during female orgasm, has a composition somewhat similar to the fluid generated in males by the prostate gland,^[4]^[5] containing biochemical markers of sexual function like human urinary protein 1^[6] and the enzyme PDE5 where women without the gland had lower concentrations.^[7] When examined with electron microscopy, both glands show similar secretory structures,^[8] and both act similarly in terms of prostate-specific antigen and prostatic acid phosphatase studies.^[9]^[10]^[11]^[12] Because they are increasingly perceived as merely different versions of the same gland, some researchers are moving away from the term Skene's gland and are referring to it instead as the female prostate.^[13]

In 2002, Emanuele Jannini of University of L'Aquila in Italy showed that there may be an explanation both for female ejaculation and for the frequent denials of its existence. Skene's glands have highly variable anatomy, and in some extreme cases they appear to be absent entirely. If Skene's glands are the cause of female ejaculation and G-spot orgasms, this may explain the absence of the phenomenon in many women.^[14]^[15]

It has been demonstrated that a large amount of fluid can be secreted from this gland when stimulated from inside the vagina.^[16] Some reports indicate that embarrassment regarding female ejaculation, and the debated notion that the substance is urine, can lead to purposeful suppression of sexual climax, leading women to seek medical advice and even undergo surgery to "stop the urine".^[17]

Clinical significance

Disorders of or related to the Skene's gland include:

Infection (skenitis)^[18]^[19]

A Skene's duct cyst, pressing the urethral opening towards the right side of the image.

Skene's duct cyst^[20]

History

While the glands were first described by the French surgeon Alphonse Guérin (1816-1895), they were named after the Scottish gynaecologist Alexander Skene, who wrote about it in Western medical literature in 1880.^[21]^[22]^[23]

References

^ "paraurethral glands" at Dorland's Medical Dictionary
^ Zaviacic M, Jakubovská V, Belosovic M, Breza J (2000). "Ultrastructure of the normal adult human female prostate gland (Skene's gland)". Anat Embryol (Berl) 201 (1): 51–61. doi:10.1007/PL00022920. PMID 10603093.
^ Rabinerson D, Horowitz E (February 2007). "[G-spot and female ejaculation: fiction or reality?]". Harefuah (in Hebrew) 146 (2): 145–7, 163. PMID 17352286.
^ Kratochvíl S (1994). "Orgasmic expulsions in women". Cesk Psychiatr 90 (2): 71–7. PMID 8004685.
^ Wimpissinger F, Stifter K, Grin W, Stackl W (2007). "The Female Prostate Revisited: Perineal Ultrasound and Biochemical Studies of Female Ejaculate". The Journal of Sexual Medicine 4 (5): 1388–93. doi:10.1111/j.1743-6109.2007.00542.x. PMID 17634056.
^ Zaviacic M, Danihel L, Ruzicková M, Blazeková J, Itoh Y, Okutani R, Kawai T (March 1997). "Immunohistochemical localization of human protein 1 in the female prostate (Skene's gland) and the male prostate". Histochem J. 29 (3): 219–27. doi:10.1023/A:1026401909678. PMID 9472384.
^ Nicola Jones (3 July 2002). "Bigger is better when it comes to the G-Spot". New Scientist.
^ Zaviacic M, Jakubovská V, Belosovic M, Breza J (January 2000). "Ultrastructure of the normal adult human female prostate gland (Skene's gland)". Anat Embryol (Berl). 201 (1): 51–61. doi:10.1007/PL00022920. PMID 10603093. Retrieved 2007-06-22.
^ Zaviacic M, Ruzicková M, Jakubovský J, Danihel L, Babál P, Blazeková J (November 1994). "The significance of prostate markers in the orthology of the female prostate". Bratisl Lek Listy. 95 (11): 491–7. PMID 7533639.
^ Wernert N, Albrech M, Sesterhenn I, Goebbels R, Bonkhoff H, Seitz G, Inniger R, Remberger K (1992). "The 'female prostate': location, morphology, immunohistochemical characteristics and significance". Eur Urol. 22 (1): 64–9. PMID 1385145.
^ Tepper SL, Jagirdar J, Heath D, Geller SA (May 1984). "Homology between the female paraurethral (Skene's) glands and the prostate. Immunohistochemical demonstration". Arch Pathol Lab Med. 108 (5): 423–5. PMID 6546868.
^ Pollen JJ, Dreilinger A (March 1984). "Immunohistochemical identification of prostatic acid phosphatase and prostate specific antigen in female periurethral glands". Urology. 23 (3): 303–4. doi:10.1016/S0090-4295(84)90053-0. PMID 6199882.
^ Zaviacic M, Ablin RJ (January 2000). "The female prostate and prostate-specific antigen. Immunohistochemical localization, implications of this prostate marker in women and reasons for using the term "prostate" in the human female". Histol Histopathol. 15 (1): 131–42. PMID 10668204.
^ Jannini EA, Simonelli C, Lenzi A (2002). "Sexological approach to ejaculatory dysfunction". Int J Androl 25 (6): 317–23. doi:10.1046/j.1365-2605.2002.00371.x. PMID 12406363.
^ Jannini EA, Simonelli C, Lenzi A (2002). "Disorders of ejaculation". J Endocrinol Invest 25 (11): 1006–19. doi:10.1007/bf03344077. PMID 12553564.
^ Heath D (1984). "An investigation into the origins of a copious vaginal discharge during intercourse: "Enough to wet the bed" - that "is not urine"". J Sex Res. 20 (2): 194–215. doi:10.1080/00224498409551217.
^ Chalker, Rebecca (2002). The Clitoral Truth: The secret world at your fingertips. New York: Seven Stories. ISBN 1-58322-473-4. Retrieved 2013-11-03.
^ Miranda EP, Almeida DC, Ribeiro GP, Parente JM, Scafuri AG (2008). "Surgical Treatment for Recurrent Refractory Skenitis" (PDF). TheScientificWorldJOURNAL 8: 658–660. doi:10.1100/tsw.2008.92. PMID 18661053.
^ Gittes RF, Nakamura RM (May 1996). "Female urethral syndrome. A female prostatitis?". Western Journal of Medicine 164 (5): 435–438. PMC 1303542. PMID 8686301.
^ S. Gene McNeeley, MD (December 2008). "Skene's duct cyst". Merck Manuals Online Medical Library. Merck. Retrieved 5 March 2010.
^ Skene's glands at Who Named It?
^ Skene A (1880). "The anatomy and pathology of two important glands of the female urethra". Am J Obs Dis Women Child 13: 265–70.
^ synd/2037 at Who Named It?

External links

Davì G, Asta G, Lagalla R, Midiri M, Mercadante G (1999). "Skene's gland pseudocysts. An occasional finding with computed tomography and ultrasound". La Radiologia medica 98 (4): 314–316. PMID 10615378.
Radiology images of the Skene's gland
Jones N (3 July 2002). "Bigger is better when it comes to the G spot". New Scientist.
Geddes L (20 February 2008). "Ultrasound nails location of the elusive G spot". New Scientist.
Gravina GL, Brandetti F, Martini P, Carosa E, Di Stasi SM, Morano S, Lenzi A, Jannini EA (March 2008). "Measurement of the thickness of the urethrovaginal space in women with or without vaginal orgasm". J Sex Med 5 (3): 610–8. doi:10.1111/j.1743-6109.2007.00739.x. PMID 18221286.

UpToDate Contents

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1. 外陰膿瘍 vulvar abscess
2. 婦人科歴および内診 the gynecologic history and pelvic examination
3. 女性における尿道憩室 urethral diverticulum in women
4. 女性泌尿生殖器の外科解剖学 surgical female urogenital anatomy
5. Clinical manifestations and diagnosis of localized vulvar pain syndrome (formerly vulvodynia, vestibulodynia, vulvar vestibulitis, or focal vulvitis)

English Journal

[Tubulo-squamous polyp of the vagina].

Petrová M, Laco J, Červíček K, Tomšová M.
Ceská gynekologie / Ceská lékarská spolecnost J. Ev. Purkyne.Ceska Gynekol.2015 Summer;80(3):173-5.
OBJECTIVE: To decribe a case of rare type of vaginal polyp.DESIGN: Case report.SETTING: Department of Pathological Anatomy, Regional hospital Nachod.CONCLUSION: Tubulo-squamous polyp is rare type of vaginal polyp first described in 2007, with only up to 20 cases have been reported in the literature
PMID 26087210

Clinical anatomy of the G-spot.

Pan S1, Leung C, Shah J, Kilchevsky A.
Clinical anatomy (New York, N.Y.).Clin Anat.2015 Apr;28(3):363-7. doi: 10.1002/ca.22523. Epub 2015 Mar 4.
The existence of the G-Spot has never been unequivocally confirmed. With increased public exposure and a trend towards sexual gratification, however, the impetus to elucidate this structure is greater than ever. This review will focus on research that has been conducted on the clinical anatomy of th
PMID 25740385

Lesions of Skene glands and periurethral region: a review.

Heller DS1.
Journal of lower genital tract disease.J Low Genit Tract Dis.2015 Apr;19(2):170-4. doi: 10.1097/LGT.0000000000000059.
The periurethral (Skene) glands may become involved by a variety of conditions. Mass-like lesions need to be distinguished from other lesions arising from the anterior vagina. Familiarity with these lesions will be helpful if a patient with a lesion of the Skene glands or periurethral region is enco
PMID 24983349

Japanese Journal

Metastasizing Adenocarcinoma of the Female Prostate (Skene's Paraurethral Glands) : Histological and Immunohistochemical Prostate Markers Studies and First Ultrastructural Observation

SLOBODA Juraj,ZAVIACIC Milan,JAKUBOVSKY Jan,HAMMAR Eric,JOHNSEN John
Pathology, research and practice 194(2), 129-136, 1998-02-01
NAID 10020454683

Prostate specific antigen and prostate specific acid phosphatase in adenocarcinoma of Skene's paraurethral glands and ducts

ZAVIACIC M
Virchows Arch A Pathol Anat 423, 503-505, 1993
NAID 30014138344

「スキーン腺」

Skene's gland
	Skene's gland opening is pictured.
Details
Latin	glandulae vestibulares minores
Precursor	Urogenital sinus
Identifiers
Gray's	p.1213
Dorlands; /Elsevier	Paraurethral glands
TA	A09.2.01.017
FMA	71648
	Anatomical terminology

　　[★]

英: Skene gland, Skene glands
同: 小前庭腺 lesser vestibular gland、副尿道、尿道傍管 paraurethral ducts

[1] "paraurethral glands" at Dorland's Medical Dictionary

[2] Zaviacic M, Jakubovská V, Belosovic M, Breza J (2000). "Ultrastructure of the normal adult human female prostate gland (Skene's gland)". Anat Embryol (Berl) 201 (1): 51–61. doi:10.1007/PL00022920. PMID 10603093.

[3] Rabinerson D, Horowitz E (February 2007). "[G-spot and female ejaculation: fiction or reality?]". Harefuah (in Hebrew) 146 (2): 145–7, 163. PMID 17352286.

[4] Kratochvíl S (1994). "Orgasmic expulsions in women". Cesk Psychiatr 90 (2): 71–7. PMID 8004685.

[5] Wimpissinger F, Stifter K, Grin W, Stackl W (2007). "The Female Prostate Revisited: Perineal Ultrasound and Biochemical Studies of Female Ejaculate". The Journal of Sexual Medicine 4 (5): 1388–93. doi:10.1111/j.1743-6109.2007.00542.x. PMID 17634056.

[6] Zaviacic M, Danihel L, Ruzicková M, Blazeková J, Itoh Y, Okutani R, Kawai T (March 1997). "Immunohistochemical localization of human protein 1 in the female prostate (Skene's gland) and the male prostate". Histochem J. 29 (3): 219–27. doi:10.1023/A:1026401909678. PMID 9472384.

[7] Nicola Jones (3 July 2002). "Bigger is better when it comes to the G-Spot". New Scientist.

[8] Zaviacic M, Jakubovská V, Belosovic M, Breza J (January 2000). "Ultrastructure of the normal adult human female prostate gland (Skene's gland)". Anat Embryol (Berl). 201 (1): 51–61. doi:10.1007/PL00022920. PMID 10603093. Retrieved 2007-06-22.

[9] Zaviacic M, Ruzicková M, Jakubovský J, Danihel L, Babál P, Blazeková J (November 1994). "The significance of prostate markers in the orthology of the female prostate". Bratisl Lek Listy. 95 (11): 491–7. PMID 7533639.

[10] Wernert N, Albrech M, Sesterhenn I, Goebbels R, Bonkhoff H, Seitz G, Inniger R, Remberger K (1992). "The 'female prostate': location, morphology, immunohistochemical characteristics and significance". Eur Urol. 22 (1): 64–9. PMID 1385145.

[11] Tepper SL, Jagirdar J, Heath D, Geller SA (May 1984). "Homology between the female paraurethral (Skene's) glands and the prostate. Immunohistochemical demonstration". Arch Pathol Lab Med. 108 (5): 423–5. PMID 6546868.

[12] Pollen JJ, Dreilinger A (March 1984). "Immunohistochemical identification of prostatic acid phosphatase and prostate specific antigen in female periurethral glands". Urology. 23 (3): 303–4. doi:10.1016/S0090-4295(84)90053-0. PMID 6199882.

[13] Zaviacic M, Ablin RJ (January 2000). "The female prostate and prostate-specific antigen. Immunohistochemical localization, implications of this prostate marker in women and reasons for using the term "prostate" in the human female". Histol Histopathol. 15 (1): 131–42. PMID 10668204.

[14] Jannini EA, Simonelli C, Lenzi A (2002). "Sexological approach to ejaculatory dysfunction". Int J Androl 25 (6): 317–23. doi:10.1046/j.1365-2605.2002.00371.x. PMID 12406363.

[15] Jannini EA, Simonelli C, Lenzi A (2002). "Disorders of ejaculation". J Endocrinol Invest 25 (11): 1006–19. doi:10.1007/bf03344077. PMID 12553564.

[heath-16] Heath D (1984). "An investigation into the origins of a copious vaginal discharge during intercourse: "Enough to wet the bed" - that "is not urine"". J Sex Res. 20 (2): 194–215. doi:10.1080/00224498409551217.

[chalker-17] Chalker, Rebecca (2002). The Clitoral Truth: The secret world at your fingertips. New York: Seven Stories. ISBN 1-58322-473-4. Retrieved 2013-11-03.

[miranda-18] Miranda EP, Almeida DC, Ribeiro GP, Parente JM, Scafuri AG (2008). "Surgical Treatment for Recurrent Refractory Skenitis" (PDF). TheScientificWorldJOURNAL 8: 658–660. doi:10.1100/tsw.2008.92. PMID 18661053.

[gittes-19] Gittes RF, Nakamura RM (May 1996). "Female urethral syndrome. A female prostatitis?". Western Journal of Medicine 164 (5): 435–438. PMC 1303542. PMID 8686301.

[20] S. Gene McNeeley, MD (December 2008). "Skene's duct cyst". Merck Manuals Online Medical Library. Merck. Retrieved 5 March 2010.

[21] Skene's glands at Who Named It?

[22] Skene A (1880). "The anatomy and pathology of two important glands of the female urethra". Am J Obs Dis Women Child 13: 265–70.

[23] synd/2037 at Who Named It?

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案内

Skene glands