シンドビスウイルス
WordNet
- a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
- (virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
- a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
PrepTutorEJDIC
- ビールス,ろ過性病原体
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/11 16:29:48」(JST)
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| Sindbis virus |
|
| CryoEM model of Sindbis virus. EMDB entry EMD-2374[1] |
| Virus classification |
| Group: |
Group IV ((+)ssRNA) |
| Family: |
Togaviridae |
| Genus: |
Alphavirus |
| Species: |
Sindbis virus |
Sindbis Virus (SINV) is a member of the Togaviridae family, in the alphavirus subfamily. The virus was first isolated in 1952 in Cairo, Egypt. The virus is transmitted by mosquitoes (Culex spp.) SINV causes sindbis fever in humans and the symptoms include arthralgia, rash and malaise. Sindbis fever is most common in South and East Africa, Egypt, Israel, Philippines and parts of Australia. Sindbis virus is an "arbovirus" (arthropod-borne) and is maintained in nature by transmission between vertebrate (bird) hosts and invertebrate (mosquito) vectors. Humans are infected with Sindbis virus when bitten by an infected mosquito. SINV has been linked to Pogosta disease in Finland,[2] Ockelbo disease in Sweden and Karelian fever in Russia.
Contents
- 1 Virus structure, genome and replication
- 2 See also
- 3 References
- 4 External links
Virus structure, genome and replication
Sindbis viruses are enveloped particles with an icosahedral capsid. Its genome is a single stranded RNA approximately 11.7kb long. It has a 5' cap and 3' polyadenylated tail therefore serves directly as messenger RNA (mRNA) in a host cell. The genome encodes four non-structural proteins at the 5' end and the capsid and two envelope proteins at the 3' end. This is characteristic of all Togaviruses. Replication is cytoplasmic and rapid. The genomic RNA is partially translated at the 5’ end to produce the non-structural proteins which are then involved in genome replication and the production of new genomic RNA and a shorter sub-genomic RNA strand. This sub-genomic strand is translated into the structural proteins. The viruses assemble at the host cell surfaces and acquire their envelope through budding.
A non-coding RNA element has been found to be essential for Sindbis virus genome replication.[3]
See also
References
- MicrobiologyBytes: Togaviruses
- CDC: Pogosta disease and Sindbis virus
- Sindbis virus - ICTVdB - The Universal Virus Database, version 4.
- ^ Cao, S.; Zhang, W. (2013). "Characterization of an early-stage fusion intermediate of Sindbis virus using cryoelectron microscopy". Proceedings of the National Academy of Sciences 110 (33): 13362–13367. doi:10.1073/pnas.1301911110. PMC 3746934. PMID 23898184.
- ^ Kurkela S, Manni T, Vaheri A, Vapalahti O. Causative agent of Pogosta disease isolated from blood and skin lesions, Emerg Infect Dis [serial on the Internet]. Published 2004 May. (accessed 2007-10-16)
- ^ Frolov, I; Hardy R; Rice CM (2001). "Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis". RNA 7 (11): 1638–1651. doi:10.1017/S135583820101010X. PMC 1370205. PMID 11720292.
External links
- Virus Pathogen Database and Analysis Resource (ViPR): Togaviridae
|
Zoonotic viral diseases (A80–B34, 042–079)
|
|
| Arthropod-borne |
| Mosquito-borne |
| Bunyaviridae |
- Arbovirus encephalitides: La Crosse encephalitis
- Batai virus (BATV)
- Bwamba Fever (BWAV)
- California encephalitis
- Jamestown Canyon virus
- Tete virus
- Tahyna virus (TAHV)
- Viral hemorrhagic fevers: Rift Valley fever
- Bunyamwera fever (BUNV)
- Ngari virus (NRIV)
|
|
| Flaviviridae |
- Arbovirus encephalitides: Japanese encephalitis
- Australian encephalitis
- Saint Louis encephalitis
- West Nile fever
- Viral hemorrhagic fevers: Dengue fever
- Yellow fever
- Zika fever
|
|
| Togaviridae |
- Arbovirus encephalitides: Eastern equine encephalomyelitis
- Western equine encephalomyelitis
- Venezuelan equine encephalomyelitis
- Chikungunya
- O'Nyong-nyong fever
- Ross River fever
- Semliki Forest virus
- Sindbis fever
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|
| Reoviridae |
|
|
|
| Tick-borne |
| Bunyaviridae |
- Viral hemorrhagic fevers: Crimean–Congo hemorrhagic fever
- Heartland virus
- Bhanja virus
- Sandfly fever Naples virus
- Lone Star virus
- Tete virus
|
|
| Flaviviridae |
- Arbovirus encephalitides: Tick-borne encephalitis
- Powassan encephalitis
- Viral hemorrhagic fevers: Omsk hemorrhagic fever
- Kyasanur forest disease
- Langat virus (LGTV)
|
|
| Reoviridae |
- Colorado tick fever
- Kemerovo tickborne viral fever
|
|
|
| Sandfly-borne |
| Bunyaviridae |
- Adria virus (ADRV)
- Pappataci fever
- Sandfly fever Naples virus
- Oropouche fever
- SFTS virus
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|
| Rhabdoviridae |
|
|
|
|
| Mammal-borne |
| Rodent-borne |
| Arenaviridae |
- Viral hemorrhagic fevers: Lassa fever
- Venezuelan hemorrhagic fever
- Argentine hemorrhagic fever
- Brazilian hemorrhagic fever
- Bolivian hemorrhagic fever
- LUJV
- CHPV
|
|
| Bunyaviridae |
- Hemorrhagic fever with renal syndrome
- Hantavirus pulmonary syndrome
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|
|
| Bat-borne |
| Filoviridae |
- Viral hemorrhagic fevers: Ebola virus disease
- BDBV
- EBOV
- SUDV
- TAFV
- Marburg virus disease
- MARV
- RAVV
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|
| Rhabdoviridae |
|
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| Paramyxoviridae |
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|
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| Primate-borne |
| Herpesviridae |
|
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| Retroviridae |
- Simian foamy virus
- HTLV-1
- HTLV-2
|
|
| Poxviridae |
- Tanapox
- Yaba monkey tumor virus
|
|
|
| Multiple vectors |
|
|
|
UpToDate Contents
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English Journal
- An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo.
- Wollish AC, Ferris MT, Blevins LK, Loo YM, Gale M Jr, Heise MT.SourceDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA; Carolina Vaccine Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
- Virology.Virology.2013 Jan 20;435(2):269-80. doi: 10.1016/j.virol.2012.09.008. Epub 2012 Oct 17.
- The AR86 strain of Sindbis virus causes lethal neurologic disease in adult mice. Previous studies have identified a virulence determinant at nonstructural protein (nsP) 1 position 538 that regulates neurovirulence, modulates clearance from the CNS, and interferes with the type I interferon pathway.
- PMID 23084425
- Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila.
- Kemp C, Mueller S, Goto A, Barbier V, Paro S, Bonnay F, Dostert C, Troxler L, Hetru C, Meignin C, Pfeffer S, Hoffmann JA, Imler JL.SourceCNRS-UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg Cedex, France;
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2013 Jan 15;190(2):650-8. doi: 10.4049/jimmunol.1102486. Epub 2012 Dec 19.
- The fruit fly Drosophila melanogaster is a good model to unravel the molecular mechanisms of innate immunity and has led to some important discoveries about the sensing and signaling of microbial infections. The response of Drosophila to virus infections remains poorly characterized and appears to i
- PMID 23255357
- Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression.
- Kaur P, Thiruchelvan M, Lee RC, Chen H, Chen KC, Ng ML, Chu JJ.SourceLaboratory of Molecular RNA Virology and Antiviral Strategies.
- Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Jan;57(1):155-67. doi: 10.1128/AAC.01467-12. Epub 2012 Oct 22.
- Chikungunya virus (CHIKV) is a mosquito-transmitted virus that has reemerged as a significant public health threat in the last decade. Since the 2005-2006 chikungunya fever epidemic in the Indian Ocean island of La Réunion, millions of people in more than 40 countries have been infected. Despite th
- PMID 23275491
Japanese Journal
- 瀧 公介,井之口 文月,相見 良成 [他]
- 聴覚研究会資料 = Proceedings of the auditory research meeting 44(4), 225-228, 2014-05-30
- NAID 40020128624
- ラット聴覚脳幹における皮質遠心線維終末のゴルジ様染色像の解析
- 単一ニューロンの新しい解析手法--ウイルスを用いた標識法 (特集 神経回路解析法の最近の進歩)
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