English Journal

Two Peptides from Soy β-Conglycinin Induce a Hypocholesterolemic Effect at HepG2 Cells by a Statin-like Mechanism: Comparative in Vitro and in Silico Modeling Studies.

Lammi C, Zanoni C, Arnoldi A, Vistoli G.
Journal of agricultural and food chemistry.J Agric Food Chem.2015 Aug 27. [Epub ahead of print]
Two peptides from soybean -conglycinin, i.e. YVVNPDNDEN (peptide 2) and YVVNPDNNEN (peptide 3), are known to be absorbed by human enterocytes. The former is a fragment of LRVPAGTTFYVVNPDNDENLRMIA (peptide 1), previously shown to increase the low-density-lipoprotein (LDL) uptake and degradation in
PMID 26310992

Cinnamon extract improves the body composition and attenuates lipogenic processes in the liver and adipose tissue of rats.

Lopes BP1, Gaique TG, Souza LL, Paula GS, Kluck GE, Atella GC, Gomes AC, Simas NK, Kuster RM, Ortiga-Carvalho TM, Pazos-Moura CC, Oliveira KJ.
Food & function.Food Funct.2015 Aug 3. [Epub ahead of print]
In models of metabolic disorders, cinnamon improves glucose and lipid metabolism. This study explores the effect of chronic supplementation with aqueous cinnamon extract (CE) on the lipid metabolism of rats. Male adult Wistar rats were separated into a control group (CTR) receiving water and a CE Gr
PMID 26237537

Fibronectin Overexpression Modulates Formation of Macrophage Foam Cells by Activating SREBP2 Involved in Endoplasmic Reticulum Stress.

Du H1, Wang Y, Zhang Z, Yang J, Zhang J, Zhang Y.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.Cell Physiol Biochem.2015 Jul 13;36(5):1821-1834. [Epub ahead of print]
AIMS: To explore the explicit role of fibronectin (FN) isforms in atherosclerotic lesions and the underlying mechanisms.METHODS AND RESULTS: Inducible stable expression was performed, and similar results were observed between EDA+FN (FN containing EDA domain) and EDA-FN (FN devoid of EDA domain). FN
PMID 26184741

Japanese Journal

Colestimide improves glycemic control via hepatic glucose production in db/db mice

Yamakawa Tadashi,Ogihara Kikumi,Utsunomiya Hirotoshi,Muraoka Tomonori,Kadonosono Kazuaki,Terauchi Yasuo
Endocrine Journal 61(5), 425-436, 2014
… Colestimide suppressed hepatic gene expression of SHP, but enhanced SREBP2 expression. … On the other hand, CA increased the expression of SHP and lipogenic enzymes such as ACC and SCD-1, but had no effect on SREBP2. …
NAID 130004443964

Pitavastatin Increases ABCA1 Expression by Dual Mechanisms : SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells

Maejima Takashi,Sugano Tomohiro,Yamazaki Hiroyuki [他],YOSHINAKA Yasunobu,DOI Takeshi,TANABE Sohei,NISHIMAKI MOGAMI Tomoko
Journal of pharmacological sciences 116(1), 107-115, 2011-05-20
… Hepatic ABCA1 expression in rats is regulated by both liver X receptor (LXR) and sterol regulatory element–binding protein (SREBP2) pathways. … These data suggest that pitavastatin increases ABCA1 protein expression by dual mechanisms: SREBP2-mediated mRNA transcription and PPAR<I>α</I>-mediated ABCA1 protein stabilization, but not by the PPAR–LXR–ABCA1 pathway. …
NAID 10029894164