English Journal
- High frequency of mismatch repair deficiency among pediatric high grade gliomas in Jordan.
- Amayiri N1, Tabori U2,3,4, Campbell B2,3, Bakry D2,3, Aronson M5, Durno C5,6, Rakopoulos P7, Malkin D2,3, Qaddoumi I8, Musharbash A9, Swaidan M10, Bouffet E2,3, Hawkins C7, Al-Hussaini M11; BMMRD Consortium.
- International journal of cancer.Int J Cancer.2016 Jan 15;138(2):380-5. doi: 10.1002/ijc.29724. Epub 2015 Aug 21.
- Biallelic mismatch repair deficiency (bMMRD) is a cancer predisposition syndrome affecting primarily individuals from consanguinous families resulting in multiple childhood cancers including high grade gliomas (HGG). This is the first study to assess the prevalence of bMMRD among patients with HGG i
- PMID 26293621
- Treatment Outcome and Prognostic Molecular Markers of Supratentorial Primitive Neuroectodermal Tumors.
- Choi SH1, Kim SH2, Shim KW3, Han JW4, Choi J5, Kim DS3, Lyu CJ4, Kim JW6, Suh CO1, Cho J1.
- PloS one.PLoS One.2016 Apr 13;11(4):e0153443. doi: 10.1371/journal.pone.0153443. eCollection 2016.
- BACKGROUND: To identify prognostic factors and define the optimal management of patients with supratentorial primitive neuroectodermal tumors (sPNETs), we investigated treatment outcomes and explored the prognostic value of specific molecular markers.METHODS: A total of 47 consecutive patients with
- PMID 27074032
- Take It Down a NOTCH in Forebrain Tumors.
- Oldrini B1, Schuhmacher AJ1, Squatrito M2.
- Cancer cell.Cancer Cell.2015 Dec 14;28(6):681-2. doi: 10.1016/j.ccell.2015.11.008.
- In this issue of Cancer Cell, Giachino and colleagues, employing various approaches, describe a tumor suppressor function for Notch signaling in forebrain tumors and suggest that decreased Notch activity could be a key molecular event in supratentorial primitive neuroectodermal tumors (sPNET). Copyr
- PMID 26678333
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