SLC7A1

• cationic amino acid transporter 1

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/26 14:26:56」(JST)

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Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Identifiers
Symbols	SLC7A1; ATRC1; CAT-1; ERR; HCAT1; REC1L
External IDs	OMIM: 104615 MGI: 88117 HomoloGene: 20658 GeneCards: SLC7A1 Gene
Gene Ontology Molecular function • arginine transmembrane transporter activity Cellular component • plasma membrane • integral to plasma membrane Biological process • transport • ion transport • amino acid transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6541	11987
Ensembl	ENSG00000139514	ENSMUSG00000041313
UniProt	P30825	Q09143
RefSeq (mRNA)	NM_003045	NM_007513
RefSeq (protein)	NP_003036	NP_031539
Location (UCSC)	Chr 13: 30.08 – 30.17 Mb	Chr 5: 148.33 – 148.4 Mb
PubMed search	[1]	[2]

High affinity cationic amino acid transporter 1 is a protein that in humans is encoded by the SLC7A1 gene.

See also

• Solute carrier family

References

Further reading

• Yoshimoto T, Yoshimoto E, Meruelo D (1991). "Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor.". Virology 185 (1): 10–7. doi:10.1016/0042-6822(91)90748-Z. PMID 1718082. 
• Kamath SG, Furesz TC, Way BA, Smith CH (1999). "Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1.". J. Membr. Biol. 171 (1): 55–62. doi:10.1007/s002329900558. PMID 10485994. 
• Hammermann R, Brunn G, Racké K (2002). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4.". Amino Acids 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818. 
• Cariappa R, Heath-Monnig E, Furesz TC et al. (2002). "Stable polarized expression of hCAT-1 in an epithelial cell line". J. Membr. Biol. 186 (1): 23–30. doi:10.1007/s00232-001-0133-y. PMID 11891586. 
• Furesz TC, Heath-Monnig E, Kamath SG, Smith CH (2003). "Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes". J. Membr. Biol. 189 (1): 27–33. doi:10.1007/s00232-002-1001-0. PMID 12202949. 
• Kizhatil K, Albritton LM (2002). "System y+ localizes to different membrane subdomains in the basolateral plasma membrane of epithelial cells". Am. J. Physiol., Cell Physiol. 283 (6): C1784–94. doi:10.1152/ajpcell.00061.2002. PMID 12388095. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Schnorr O, Suschek CV, Kolb-Bachofen V (2003). "The importance of cationic amino acid transporter expression in human skin". J. Invest. Dermatol. 120 (6): 1016–22. doi:10.1046/j.1523-1747.2003.12139.x. PMID 12787129. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Dunham A, Matthews LH, Burton J et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823. 
• González M, Flores C, Pearson JD et al. (2005). "Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells". Pflugers Arch. 448 (4): 383–94. doi:10.1007/s00424-004-1261-x. PMID 15064952. 
• Schwartz IF, Iaina A, Benedict Y et al. (2004). "Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats". Kidney Int. 65 (4): 1311–9. doi:10.1111/j.1523-1755.2004.00508.x. PMID 15086470. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rotmann A, Strand D, Martiné U, Closs EI (2005). "Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity". J. Biol. Chem. 279 (52): 54185–92. doi:10.1074/jbc.M409556200. PMID 15491978. 
• Cui Z, Tuladhar R, Hart SL et al. (2005). "Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells". Nitric Oxide 12 (1): 21–30. doi:10.1016/j.niox.2004.11.001. PMID 15631944. 
• Yang Z, Venardos K, Jones E et al. (2007). "Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction". Circulation 115 (10): 1269–74. doi:10.1161/CIRCULATIONAHA.106.665836. PMID 17325243. 
• Kaneko S, Okuda-Ashitaka E, Ando A et al. (2007). "Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells". Am. J. Physiol., Cell Physiol. 293 (2): C729–37. doi:10.1152/ajpcell.00018.2007. PMID 17494634. 

English Journal

• Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise.

• Dickinson JM, Drummond MJ, Coben JR, Volpi E, Rasmussen BB.SourceDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX 77555, United States. jadickin@utmb.edu
• Clinical nutrition (Edinburgh, Scotland).Clin Nutr.2013 Apr;32(2):273-80. doi: 10.1016/j.clnu.2012.07.009. Epub 2012 Aug 1.
• BACKGROUND & AIMS: Amino acid transporters have been proposed as regulators of protein synthesis. The primary aim of this study was to determine whether amino acid transporter expression is increased in human muscle following resistance exercise (RE) coupled with essential amino acid (EAA) inges
• PMID 22889597

• Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer.

• Camps J, Pitt JJ, Emons G, Hummon AB, Case CM, Grade M, Jones TL, Nguyen QT, Ghadimi BM, Beissbarth T, Difilippantonio MJ, Caplen NJ, Ried T.SourceAuthors' Affiliations: Cancer Genomics Section and Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; and Department of General and Visceral Surgery, University Medicine Göttingen, Göttingen, Germany.
• Cancer research.Cancer Res.2013 Mar 15;73(6):2003-13. doi: 10.1158/0008-5472.CAN-12-3159. Epub 2013 Jan 14.
• Chromosomal copy number alterations (aneuploidy) define the genomic landscape of most cancer cells, but identification of the oncogenic drivers behind these imbalances remains an unfinished task. In this study, we conducted a systematic analysis of colorectal carcinomas that integrated genomic copy
• PMID 23319804

• Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.

• Ramachandran J, Schneider JS, Crassous PA, Zheng R, Gonzalez JP, Xie LH, Beuve A, Fraidenraich D, Peluffo RD.SourceDepartment of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, U.S.A.
• The Biochemical journal.Biochem J.2013 Jan 1;449(1):133-42. doi: 10.1042/BJ20120787.
• DMD (Duchenne muscular dystrophy) is an incurable rapidly worsening neuromuscular degenerative disease caused by the absence of dystrophin. In skeletal muscle a lack of dystrophin disrupts the recruitment of neuronal NOS (nitric oxide synthase) to the sarcolemma thus affecting NO (nitric oxide) prod
• PMID 23009292

Japanese Journal

• Underlying mechanisms involved in the decrease of milk secretion during Escherichia coli endotoxin induced mastitis in lactating mice

• Kobayashi Ken,Oyama Shoko,Uejyo Takaaki,Kuki Chinatsu,Rahman Md Morshedur,Kumura Haruto
• Veterinary research 44, 2013-12-05
• … SLC7A1, an amino acid transporter, was up-regulated 3 and 6 h after LPS injection. …
• NAID 120005372283

• Select Nutrients in the Uterine Lumen of Sheep and Pigs Affect Conceptus Development

• BAZER Fuller W.,KIM Jinyoung,KA Hakhyun [他],JOHNSON Gregory A.,WU Guoyao,SONG Gwonhwa
• The Journal of reproduction and development 58(2), 180-188, 2012-04-01
• … Transporters for glutamate and neutral (SLC1A1, SLC1A4) and cationic (SLC7A1, SLC7A2, SLC7A7, SLC7A9) amino acids are expressed in uterine LE and SLC7A3 mRNA is expressed in conceptus Tr. …
• NAID 10030753562

• Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1. Contribution to hypertension and endothelial dysfunction

• YANG Z
• Circulation 115, 1269-1274, 2007
• NAID 30026118341

Related Links

• ヒト iPS 細胞の樹立方法 - 京都大学 iPS細胞研究所

2008年7月4日 ... マウス Slc7a1 発現用レンチウイルスベクター. Addgene (http://www.addgene.org/ Shinya_Yamanaka) より入手できる pLenti6/UbC/V5-DEST. (Invitrogen 社) に マウスエコトロピックレセプターをコードする Slc7a1 (Solute carrier family 7.

• SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ ...

SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 [Homo sapiens (human)]. Gene ID: 6541, updated on 9-Jun-2013. Summary. Other designations. CAT1, amino acid transporter, cationic 1, ecotropic  ...

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