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| Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
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PDB rendering based on 1okc.
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| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1okc, 2c3e
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| Identifiers |
| Symbols |
SLC25A4 ; AAC1; ANT; ANT 1; ANT1; MTDPS12; PEO2; PEO3; T1 |
| External IDs |
OMIM: 103220 MGI: 1353495 HomoloGene: 36058 ChEMBL: 1879 GeneCards: SLC25A4 Gene |
| Gene ontology |
| Molecular function |
• protein binding
• adenine transmembrane transporter activity
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| Cellular component |
• nucleus
• mitochondrion
• mitochondrial inner membrane
• integral component of plasma membrane
• myelin sheath
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| Biological process |
• mitochondrial genome maintenance
• generation of precursor metabolites and energy
• energy reserve metabolic process
• transport
• apoptotic mitochondrial changes
• adenine transport
• viral process
• small molecule metabolic process
• regulation of insulin secretion
• transmembrane transport
• negative regulation of necroptotic process
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
291 |
11739 |
| Ensembl |
ENSG00000151729 |
ENSMUSG00000031633 |
| UniProt |
P12235 |
P48962 |
| RefSeq (mRNA) |
NM_001151 |
NM_007450 |
| RefSeq (protein) |
NP_001142 |
NP_031476 |
| Location (UCSC) |
Chr 4:
185.14 – 185.15 Mb |
Chr 8:
46.21 – 46.21 Mb |
| PubMed search |
[1] |
[2] |
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ADP/ATP translocase 1 is an enzyme that in humans is encoded by the SLC25A4 gene or adenine nucleotide translocator, ANT.[1][2]
Contents
- 1 Interactions
- 2 References
- 3 Further reading
- 4 External links
Interactions
SLC25A4 has been shown to interact with Bcl-2-associated X protein.[3]
References
- ^ Fan YS, Yang HM, Lin CC (Jun 1992). "Assignment of the human muscle adenine nucleotide translocator gene (ANT1) to 4q35 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics 60 (1): 29–30. doi:10.1159/000133288. PMID 1582253.
- ^ "Entrez Gene: SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4".
- ^ Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC, Kroemer G (Sep 1998). "Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science 281 (5385): 2027–31. doi:10.1126/science.281.5385.2027. PMID 9748162.
Further reading
- Vieira HL, Haouzi D, El Hamel C, Jacotot E, Belzacq AS, Brenner C, Kroemer G (Dec 2000). "Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator". Cell Death and Differentiation 7 (12): 1146–54. doi:10.1038/sj.cdd.4400778. PMID 11175251.
- Ferri KF, Jacotot E, Blanco J, Esté JA, Kroemer G (2001). "Mitochondrial control of cell death induced by HIV-1-encoded proteins". Annals of the New York Academy of Sciences 926: 149–64. doi:10.1111/j.1749-6632.2000.tb05609.x. PMID 11193032.
- Kino T, Pavlakis GN (Apr 2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA and Cell Biology 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
- Andersen JL, Planelles V (Jan 2005). "The role of Vpr in HIV-1 pathogenesis". Current HIV Research 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
- Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. PMID 15817944.
- Muthumani K, Choo AY, Premkumar A, Hwang DS, Thieu KP, Desai BM, Weiner DB (Aug 2005). "Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism". Cell Death and Differentiation. 12 Suppl 1: 962–70. doi:10.1038/sj.cdd.4401583. PMID 15832179.
- Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research 15 (11-12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
- Moon HS, Yang JS (Feb 2006). "Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells". Molecules and Cells 21 (1): 7–20. PMID 16511342.
- Cozens AL, Runswick MJ, Walker JE (Mar 1989). "DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase". Journal of Molecular Biology 206 (2): 261–80. doi:10.1016/0022-2836(89)90477-4. PMID 2541251.
- Li K, Warner CK, Hodge JA, Minoshima S, Kudoh J, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Wallace DC (Aug 1989). "A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed". The Journal of Biological Chemistry 264 (24): 13998–4004. PMID 2547778.
- Neckelmann N, Li K, Wade RP, Shuster R, Wallace DC (Nov 1987). "cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes". Proceedings of the National Academy of Sciences of the United States of America 84 (21): 7580–4. doi:10.1073/pnas.84.21.7580. PMC 299343. PMID 2823266.
- Houldsworth J, Attardi G (Jan 1988). "Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver". Proceedings of the National Academy of Sciences of the United States of America 85 (2): 377–81. doi:10.1073/pnas.85.2.377. PMC 279551. PMID 2829183.
- Wijmenga C, Winokur ST, Padberg GW, Skraastad MI, Altherr MR, Wasmuth JJ, Murray JC, Hofker MH, Frants RR (Sep 1993). "The human skeletal muscle adenine nucleotide translocator gene maps to chromosome 4q35 in the region of the facioscapulohumeral muscular dystrophy locus". Human Genetics 92 (2): 198–203. doi:10.1007/BF00219692. PMID 8103757.
- Bakker HD, Scholte HR, Van den Bogert C, Ruitenbeek W, Jeneson JA, Wanders RJ, Abeling NG, Dorland B, Sengers RC, Van Gennip AH (Apr 1993). "Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial defect". Pediatric Research 33 (4 Pt 1): 412–7. doi:10.1203/00006450-199304000-00019. PMID 8479824.
- Kaukonen JA, Amati P, Suomalainen A, Rötig A, Piscaglia MG, Salvi F, Weissenbach J, Fratta G, Comi G, Peltonen L, Zeviani M (Apr 1996). "An autosomal locus predisposing to multiple deletions of mtDNA on chromosome 3p". American Journal of Human Genetics 58 (4): 763–9. PMC 1914672. PMID 8644740.
- Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC, Kroemer G (Sep 1998). "Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science 281 (5385): 2027–31. doi:10.1126/science.281.5385.2027. PMID 9748162.
- Kaukonen J, Zeviani M, Comi GP, Piscaglia MG, Peltonen L, Suomalainen A (Jul 1999). "A third locus predisposing to multiple deletions of mtDNA in autosomal dominant progressive external ophthalmoplegia". American Journal of Human Genetics 65 (1): 256–61. doi:10.1086/302445. PMC 1378100. PMID 10364542.
- Jacotot E, Ravagnan L, Loeffler M, Ferri KF, Vieira HL, Zamzami N, Costantini P, Druillennec S, Hoebeke J, Briand JP, Irinopoulou T, Daugas E, Susin SA, Cointe D, Xie ZH, Reed JC, Roques BP, Kroemer G (Jan 2000). "The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore". The Journal of Experimental Medicine 191 (1): 33–46. doi:10.1084/jem.191.1.33. PMC 2195797. PMID 10620603.
External links
- SLC25A4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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PDB gallery
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1okc: STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE
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2c3e: THE BOVINE MITOCHONDRIAL ADP-ATP CARRIER
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Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
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Ion pumps
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| Symporter, Cotransporter |
- Na+/K+,l-
- Na/Pi3
- Na+/Cl-
- Na/glucose
- Na+/I-
- Cl-/K+
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| Antiporter (exchanger) |
- Na+/H+
- Na+/Ca2+
- Na+/(Ca2+-K+) - Cl-/HCO3- (Band 3)
- Cl-formate exchanger
- Cl-oxalate exchanger
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see also solute carrier disorders
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Index of cells
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| Description |
- Structure
- Organelles
- peroxisome
- cytoskeleton
- centrosome
- epithelia
- cilia
- mitochondria
- Membranes
- Membrane transport
- ion channels
- vesicular transport
- solute carrier
- ABC transporters
- ATPase
- oxidoreduction-driven
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| Disease |
- Structural
- peroxisome
- cytoskeleton
- cilia
- mitochondria
- nucleus
- scleroprotein
- Membrane
- channelopathy
- solute carrier
- ATPase
- ABC transporters
- other
- extracellular ligands
- cell surface receptors
- intracellular signalling
- Vesicular transport
- Pore-forming toxins
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UpToDate Contents
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English Journal
- Comprehensive analysis of the whole transcriptomes from two different pig breeds using RNA-Seq method.
- Ropka-Molik K1, Zukowski K, Eckert R, Gurgul A, Piórkowska K, Oczkowicz M.
- Animal genetics.Anim Genet.2014 Oct;45(5):674-84. doi: 10.1111/age.12184. Epub 2014 Jun 24.
- Next-generation sequencing RNA-Seq technology is a powerful tool that creates new possibilities for whole-transcriptome analysis. In our study, the RNA-Seq method was applied to analyze global changes in transcriptome from muscle tissue (m. semimembranosus) in two pig breeds (Pietrain and Polish Lan
- PMID 24961663
- SANDO syndrome in a cohort of 107 patients with CPEO and mitochondrial DNA deletions.
- Hanisch F1, Kornhuber M1, Alston CL2, Taylor RW2, Deschauer M1, Zierz S1.
- Journal of neurology, neurosurgery, and psychiatry.J Neurol Neurosurg Psychiatry.2014 Aug 20. pii: jnnp-2013-306748. doi: 10.1136/jnnp-2013-306748. [Epub ahead of print]
- OBJECTIVE: The sensory ataxic neuropathy with dysarthria and ophthalmoparesis (SANDO) syndrome is a subgroup of mitochondrial chronic progressive external ophthalmoplegia (CPEO)-plus disorders associated with multiple mitochondrial DNA (mtDNA) deletions. There is no systematic survey on SANDO in pat
- PMID 25143630
- Adenine Nucleotide Translocase 4 is Expressed Within Embryonic Ovaries and Dispensable During Oogenesis.
- Lim CH1, Brower JV2, Resnick JL3, Oh SP4, Terada N5.
- Reproductive sciences (Thousand Oaks, Calif.).Reprod Sci.2014 Jul 16. pii: 1933719114542026. [Epub ahead of print]
- Adenine nucleotide translocase (Ant) facilitates the exchange of adenosine triphosphate across the mitochondrial inner membrane and plays a critical role for bioenergetics in eukaryotes. Mice have 3 Ant paralogs, Ant1 (Slc25a4), Ant2 (Slc25a5), and Ant4 (Slc25a31), which are expressed in a tissue-de
- PMID 25031318
Japanese Journal
- Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor α (PPARα) Stimulation
- Miyazaki Masafumi,Nakagawa Ippei,Koga Shigeru [他],KASAHARA Yasushi,PATRICELLI Matthew P.
- Journal of toxicological sciences 35(1), 131-135, 2010-02-01
- … Fenofibrate and clofibrate reduced the expression of 10 and 12 proteins, respectively with the expression of ACSL1, SLC25A4, A1BG, HADHA, ATP2A2, BDH1, ETFDH, HADHB, and CPT2 being reduced in common with both of fibrate-treated groups. …
- NAID 10025983590
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