SLC20A1

• type III sodium-phosphate cotransporter protein

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/30 10:21:39」(JST)

wiki en

[Wiki en表示]

Solute carrier family 20 (phosphate transporter), member 1
Identifiers
Symbols	SLC20A1 ; GLVR1; Glvr-1; PIT1; PiT-1
External IDs	OMIM: 137570 MGI: 108392 HomoloGene: 38049 GeneCards: SLC20A1 Gene
Gene ontology Molecular function • signal transducer activity • receptor activity • inorganic phosphate transmembrane transporter activity • high-affinity inorganic phosphate:sodium symporter activity • sodium:phosphate symporter activity • sodium:inorganic phosphate symporter activity Cellular component • plasma membrane • integral component of plasma membrane • membrane Biological process • phosphate-containing compound metabolic process • transport • ion transport • signal transduction • phosphate ion transmembrane transport • sodium ion transmembrane transport • positive regulation of I-kappaB kinase/NF-kappaB signaling • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6574	20515
Ensembl	ENSG00000144136	ENSMUSG00000027397
UniProt	Q8WUM9	Q61609
RefSeq (mRNA)	NM_005415	NM_001159593
RefSeq (protein)	NP_005406	NP_001153065
Location (UCSC)	Chr 2: 112.65 – 112.66 Mb	Chr 2: 129.2 – 129.21 Mb
PubMed search	[1]	[2]

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene.

Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.[supplied by OMIM]

See also

• Solute carrier family

References

Further reading

• Takeuchi Y, Vile RG, Simpson G et al. (1992). "Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus.". J. Virol. 66 (2): 1219–22. PMC 240831. PMID 1309898.  CS1 maint: Explicit use of et al. (link)
• Johann SV, Gibbons JJ, O'Hara B (1992). "GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus.". J. Virol. 66 (3): 1635–40. PMC 240899. PMID 1531369. 
• Kaelbling M, Eddy R, Shows TB et al. (1991). "Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2.". J. Virol. 65 (4): 1743–7. PMC 239979. PMID 1672162.  CS1 maint: Explicit use of et al. (link)
• O'Hara B, Johann SV, Klinger HP et al. (1991). "Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus.". Cell Growth Differ. 1 (3): 119–27. PMID 2078500.  CS1 maint: Explicit use of et al. (link)
• Olah Z, Lehel C, Anderson WB et al. (1994). "The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.". J. Biol. Chem. 269 (41): 25426–31. PMID 7929240.  CS1 maint: Explicit use of et al. (link)
• Miller DG, Miller AD (1994). "A family of retroviruses that utilize related phosphate transporters for cell entry.". J. Virol. 68 (12): 8270–6. PMC 237294. PMID 7966619. 
• Johann SV, van Zeijl M, Cekleniak J, O'Hara B (1993). "Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species.". J. Virol. 67 (11): 6733–6. PMC 238113. PMID 8411375. 
• Tatsumi S, Segawa H, Morita K et al. (1998). "Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands.". Endocrinology 139 (4): 1692–9. doi:10.1210/en.139.4.1692. PMID 9528951.  CS1 maint: Explicit use of et al. (link)
• Palmer G, Manen D, Bonjour JP, Caverzasio J (1999). "Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region.". Gene 226 (1): 25–33. doi:10.1016/S0378-1119(98)00572-1. PMID 9889306. 
• Jono S, McKee MD, Murry CE et al. (2000). "Phosphate regulation of vascular smooth muscle cell calcification.". Circ. Res. 87 (7): E10–7. PMID 11009570.  CS1 maint: Explicit use of et al. (link)
• Farrell KB, Russ JL, Murthy RK, Eiden MV (2002). "Reassessing the role of region A in Pit1-mediated viral entry.". J. Virol. 76 (15): 7683–93. doi:10.1128/JVI.76.15.7683-7693.2002. PMC 136385. PMID 12097582. 
• Bottger P, Pedersen L (2003). "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function.". J. Biol. Chem. 277 (45): 42741–7. doi:10.1074/jbc.M207096200. PMID 12205090. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  CS1 maint: Explicit use of et al. (link)
• Matsuda A, Suzuki Y, Honda G et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.  CS1 maint: Explicit use of et al. (link)
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  CS1 maint: Explicit use of et al. (link)
• Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R (2005). "Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.". Arthritis Rheum. 52 (1): 144–54. doi:10.1002/art.20748. PMID 15641067. 
• Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  CS1 maint: Explicit use of et al. (link)
• Li X, Yang HY, Giachelli CM (2006). "Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification.". Circ. Res. 98 (7): 905–12. doi:10.1161/01.RES.0000216409.20863.e7. PMID 16527991. 
• Bøttger P, Hede SE, Grunnet M et al. (2007). "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.". Am. J. Physiol., Cell Physiol. 291 (6): C1377–87. doi:10.1152/ajpcell.00015.2006. PMID 16790504.  CS1 maint: Explicit use of et al. (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

• Extracellular Phosphate Induces the Expression of Dentin Matrix Protein 1 through the FGF Receptor in Osteoblasts.

• Nishino J1,2, Yamazaki M1, Kawai M1, Tachikawa K1, Yamamoto K1,3, Miyagawa K1,2, Kogo M2, Ozono K3, Michigami T4.
• Journal of cellular biochemistry.J Cell Biochem.2016 Sep 17. doi: 10.1002/jcb.25742. [Epub ahead of print]
• Dentin matrix protein 1 (DMP1) is an extracellular matrix protein involved in phosphate metabolism and biomineralization, and its expression markedly increases during the maturation of osteoblasts into osteocytes. We previously reported that an increased level of inorganic phosphate (Pi) in media up
• PMID 27639037

• Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction.

• Forand A1, Koumakis E2, Rousseau A3, Sassier Y3, Journe C4, Merlin JF5, Leroy C3, Boitez V3, Codogno P3, Friedlander G3, Cohen I3.
• Cell reports.Cell Rep.2016 Sep 6;16(10):2736-48. doi: 10.1016/j.celrep.2016.08.012. Epub 2016 Aug 25.
• The liver plays a central role in whole-body lipid and glucose homeostasis. Increasing dietary fat intake results in increased hepatic fat deposition, which is associated with a risk for development of insulin resistance and type 2 diabetes. In this study, we demonstrate a role for the phosphate i
• PMID 27568561

• Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice.

• Yadav MC1, Bottini M2,3, Cory E4, Bhattacharya K5, Kuss P1, Narisawa S1, Sah RL4, Beck L6, Fadeel B5, Farquharson C7, Millán JL1.
• Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.J Bone Miner Res.2016 Jun;31(6):1275-86. doi: 10.1002/jbmr.2790. Epub 2016 May 17.
• We have previously shown that ablation of either the Phospho1 or Alpl gene, encoding PHOSPHO1 and tissue-nonspecific alkaline phosphatase (TNAP) respectively, lead to hyperosteoidosis, but that their chondrocyte-derived and osteoblast-derived matrix vesicles (MVs) are able to initiate mineralization
• PMID 26773408

Related Links

• SLC20A1 Gene - GeneCards | S20A1 Protein | S20A1 Antibody

Complete information for SLC20A1 gene (protein-coding), solute carrier family 20 (phosphate transporter), member 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... ...

• PiT1/SLC20A1 (D1Z4X) Rabbit mAb #12765 | CST 抗体

米国CST社の日本法人CSTジャパン株式会社【公式サイト】PiT1/SLC20A1 (D1Z4X) Rabbit mAbページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。

Related Pictures