SLC1A1

• excitatory amino acid transporter 3

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/16 15:58:31」(JST)

wiki en

[Wiki en表示]

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Identifiers
Symbols	SLC1A1 ; DCBXA; EAAC1; EAAT3; SCZD18
External IDs	OMIM: 133550 MGI: 105083 HomoloGene: 20881 ChEMBL: 2721 GeneCards: SLC1A1 Gene
Gene ontology Molecular function • L-glutamate transmembrane transporter activity • protein binding • glutamate:sodium symporter activity • glutamate binding • sodium:dicarboxylate symporter activity • cysteine transmembrane transporter activity Cellular component • plasma membrane • integral component of plasma membrane • membrane • apical plasma membrane • extracellular exosome Biological process • ion transport • synaptic transmission • neurotransmitter secretion • positive regulation of heart rate • glutamate secretion • cysteine transport • protein homooligomerization • L-glutamate import • transmembrane transport • D-aspartate import • L-glutamate transmembrane transport • cysteine transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6505	20510
Ensembl	ENSG00000106688	ENSMUSG00000024935
UniProt	P43005	P51906
RefSeq (mRNA)	NM_004170	NM_009199
RefSeq (protein)	NP_004161	NP_033225
Location (UCSC)	Chr 9: 4.49 – 4.59 Mb	Chr 19: 28.84 – 28.91 Mb
PubMed search	[1]	[2]

SLC1A1, also known as excitatory amino-acid transporter 3 (EAAT3), is a protein that in humans is encoded by the SLC1A1 gene.

Function

Excitatory amino-acid transporter 3 is a member of the high-affinity glutamate transporters which plays an essential role in transporting glutamate across plasma membranes in neurons. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect.

Interactions

SLC1A1 has been shown to interact with ARL6IP5.

See also

• Glutamate transporter
• Solute carrier family

References

Further reading

• Nieoullon A, Canolle B, Masmejean F, Guillet B, Pisano P, Lortet S (2006). "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". J. Neurochem. 98 (4): 1007–18. doi:10.1111/j.1471-4159.2006.03978.x. PMID 16800850. 
• Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG (1994). "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex". J. Neurosci. 14 (9): 5559–69. PMID 7521911. 
• Shashidharan P, Huntley GW, Meyer T, Morrison JH, Plaitakis A (1994). "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain". Brain Res. 662 (1-2): 245–50. doi:10.1016/0006-8993(94)90819-2. PMID 7859077. 
• Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert SC, Smith CP, Hediger MA (1994). "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport". J. Biol. Chem. 269 (32): 20599–606. PMID 7914198. 
• Zerangue N, Kavanaugh MP (1996). "Interaction of L-cysteine with a human excitatory amino acid transporter". J. Physiol. (Lond.). 493 ( Pt 2) (Pt 2): 419–23. PMC 1158927. PMID 8782106. 
• Bar-Peled O, Ben-Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, Rothstein JD (1997). "Distribution of glutamate transporter subtypes during human brain development". J. Neurochem. 69 (6): 2571–80. doi:10.1046/j.1471-4159.1997.69062571.x. PMID 9375691. 
• He Y, Janssen WG, Rothstein JD, Morrison JH (2000). "Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus". J. Comp. Neurol. 418 (3): 255–69. doi:10.1002/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6. PMID 10701825. 
• Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046. 
• Veenstra-VanderWeele J, Kim SJ, Gonen D, Hanna GL, Leventhal BL, Cook EH (2001). "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder". Mol. Psychiatry 6 (2): 160–7. doi:10.1038/sj.mp.4000806. PMID 11317217. 
• Borre L, Kavanaugh MP, Kanner BI (2002). "Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter". J. Biol. Chem. 277 (16): 13501–7. doi:10.1074/jbc.M110861200. PMID 11823462. 
• González MI, Bannerman PG, Robinson MB (2003). "Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1". J. Neurosci. 23 (13): 5589–93. PMID 12843260. 
• Noorlander CW, de Graan PN, Nikkels PG, Schrama LH, Visser GH (2004). "Distribution of glutamate transporters in the human placenta". Placenta 25 (6): 489–95. doi:10.1016/j.placenta.2003.10.018. PMID 15135231. 
• Koch HP, Larsson HP (2005). "Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters". J. Neurosci. 25 (7): 1730–6. doi:10.1523/JNEUROSCI.4138-04.2005. PMID 15716409. 
• Vallejo-Illarramendi A, Domercq M, Pérez-Cerdá F, Ravid R, Matute C (2006). "Increased expression and function of glutamate transporters in multiple sclerosis". Neurobiol. Dis. 21 (1): 154–64. doi:10.1016/j.nbd.2005.06.017. PMID 16061389. 
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Rainesalo S, Keränen T, Saransaari P, Honkaniemi J (2005). "GABA and glutamate transporters are expressed in human platelets". Brain Res. Mol. Brain Res. 141 (2): 161–5. doi:10.1016/j.molbrainres.2005.08.013. PMID 16198020. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 小児および思春期における強迫性障害：疫学、病因、臨床症状、経過、評価、および診断 obsessive compulsive disorder in children and adolescents epidemiology pathogenesis clinical manifestations course assessment and diagnosis

English Journal

• Gene Signatures of 1,25-Dihydroxyvitamin D3 Exposure in Normal and Transformed Mammary Cells.

• Simmons KM1, Beaudin SG1, Narvaez CJ1, Welsh J1,2.
• Journal of cellular biochemistry.J Cell Biochem.2015 Aug;116(8):1693-711. doi: 10.1002/jcb.25129.
• To elucidate potential mediators of vitamin D receptor (VDR) action in breast cancer, we profiled the genomic effects of its ligand 1,25-dihydroxyvitamin D3 (1,25D) in cells derived from normal mammary tissue and breast cancer. In non-transformed hTERT-HME cells, 483 1,25D responsive entities in 42
• PMID 25736056

• Association between the efficacy of fluoxetine treatment in obsessive-compulsive disorder patients and SLC1A1 in a Han Chinese population.

• Zhang K1, Cao L1, Zhu W1, Wang G2, Wang Q3, Hu H3, Zhao M4.
• Psychiatry research.Psychiatry Res.2015 Jun 27. pii: S0165-1781(15)00440-0. doi: 10.1016/j.psychres.2015.06.039. [Epub ahead of print]
• PMID 26154820

• The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells.

• Pedraz-Cuesta E1, Christensen S2, Jensen AA3, Jensen NF4, Bunch L5, Romer MU6,7, Brünner N8, Stenvang J9, Pedersen SF10.
• BMC cancer.BMC Cancer.2015 May 16;15:411. doi: 10.1186/s12885-015-1405-8.
• BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer death globally and new biomarkers and treatments are severely needed.METHODS: Here, we employed HCT116 and LoVo human CRC cells made resistant to either SN38 or oxaliplatin, to investigate whether altered expression of the high affinit
• PMID 25981639

Japanese Journal

• Select Nutrients in the Uterine Lumen of Sheep and Pigs Affect Conceptus Development

• BAZER Fuller W.,KIM Jinyoung,KA Hakhyun [他],JOHNSON Gregory A.,WU Guoyao,SONG Gwonhwa
• The Journal of reproduction and development 58(2), 180-188, 2012-04-01
• … Transporters for glutamate and neutral (SLC1A1, SLC1A4) and cationic (SLC7A1, SLC7A2, SLC7A7, SLC7A9) amino acids are expressed in uterine LE and SLC7A3 mRNA is expressed in conceptus Tr. …
• NAID 10030753562

• Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder

• VEENSTRA-VANDER WEELE J.
• Mol Psychiatry 6, 160-167, 2001
• NAID 30014083896

Related Links

• SLC1A1 Gene - GeneCards | EAA3 Protein | EAA3 Antibody

SLC1A1 (Solute Carrier Family 1 Member 1) is a Protein Coding gene. Diseases associated with SLC1A1 include Dicarboxylic Aminoaciduria and Schizophrenia Susceptibility 18.

• SLC1A1 solute carrier family 1 member 1 [ (human)]

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the ...

Related Pictures