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Transcriptomic study of ciprofloxacin resistance in Streptomyces coelicolor A3(2).

Patkari M, Mehra S.SourceDepartment of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai - 400076, India. sarika@che.iitb.ac.in.
Molecular bioSystems.Mol Biosyst.2013 Dec 29;9(12):3101-16. doi: 10.1039/c3mb70341j. Epub 2013 Oct 8.
Soil organisms exhibit resistance to a wide range of antibiotics as they either need to protect themselves from endogenous antibiotics or from those present in their soil environment. The soil could serve as a reservoir for resistance mechanisms that have already emerged or have the potential to eme
PMID 24100886

Putative Role of a Streptomyces coelicolor-Derived α-Mannosidase in Deglycosylation and Antibiotic Production.

Rajesh T, Jeon JM, Song E, Park HM, Seo HM, Kim HJ, Yi DH, Kim YH, Choi KY, Kim YG, Park HY, Lee YK, Yang YH.SourceDepartment of Microbial Engineering, College of Engineering, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701, South Korea.
Applied biochemistry and biotechnology.Appl Biochem Biotechnol.2013 Nov 17. [Epub ahead of print]
SCO0948 was found to be the single open reading frame annotated to encode an α-mannosidase (AM1) in Streptomyces coelicolor M145. To characterize the protein, we overexpressed SCO0948 in Escherichia coli BL21(DE3). Recombinant AM1, with a molecular weight of 110 kDa, exhibited α-mannosidase activ
PMID 24242072

Inverse regulation of Fe- and Ni-containing SOD genes by a Fur family regulator Nur through small RNA processed from 3'UTR of the sodF mRNA.

Kim HM, Shin JH, Cho YB, Roe JH.SourceLaboratory of Molecular Microbiology, School of Biological Sciences, Institute of Microbiology, Seoul National University, Seoul 151-742, Korea.
Nucleic acids research.Nucleic Acids Res.2013 Nov 13. [Epub ahead of print]
Superoxide dismutases (SODs) are widely distributed enzymes that convert superoxides to hydrogen peroxide and molecular oxygen, using various metals as cofactors. Many actinobacteria contain genes for both Ni-containing (sodN) and Fe-containing (sodF) SODs. In Streptomyces coelicolor, expression of
PMID 24234448