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Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death.

Conradt L, Henrich A, Wirth M, Reichert M, Lesina M, Algül H, Schmid RM, Krämer OH, Saur D, Schneider G.SourceII. Medizinische Klinik, Technische Universität München, München, Germany.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 May 15;132(10):2248-57. doi: 10.1002/ijc.27916. Epub 2012 Nov 26.
Pancreatic ductal adenocarcinoma (PDAC) represents the fourth leading cause of cancer death in the western world, with a 5-year survival rate below 5%. Murine double minute 2 (Mdm2) is an important negative regulator of the tumor suppressor p53. Reactivation of wild-type p53 is a promising treatment
PMID 23115126

Expression of the calcium sensing receptor in human peripheral blood T lymphocyte and its contribution to cytokine secretion through MAPKs or NF-κB pathways.

Li T, Sun M, Yin X, Wu C, Wu Q, Feng S, Li H, Luan Y, Wen J, Yan L, Zhao B, Xu C, Sun Y.SourceDepartment of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Molecular immunology.Mol Immunol.2013 Apr;53(4):414-20. doi: 10.1016/j.molimm.2012.09.010. Epub 2012 Oct 24.
The calcium-sensing receptor (CaSR) has been reported to play an important role in many tissues and organs. However, studies about the expression and function of CaSR in T lymphocytes are still not very lucid. In this study, we investigated the above-mentioned issues using RT-PCR, immunofluorescence
PMID 23103379

Disruption of asymmetric dimethylarginine-induced RelA/P65 association with actin in endothelial cells.

Guo W, Zhang D, Wang L, Zhang Y, Liu W.SourceDepartment of Nephrology, Affiliated Beijing Friendship Hospital, Faculty of Kidney Diseases, Capital Medical University, Beijing 100050, China.
Acta biochimica et biophysica Sinica.Acta Biochim Biophys Sin (Shanghai).2013 Mar;45(3):229-35. doi: 10.1093/abbs/gms120. Epub 2013 Jan 7.
Asymmetric dimethylarginine (ADMA) activates nuclear factor (NF)-κB in endothelial cells, while actin-stabilizing or -destabilizing drugs prevent ADMA-induced activation of NF-κB. Here we investigated how actin-targeting drugs regulated ADMA-induced NF-κB activation in endothelial cells. Human um
PMID 23296075