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1. 胆汁うっ滞系酵素の測定（アルカリホスファターゼ、5' -ヌクレオチダーゼ、γ-グルタミルトランスペプチダーゼなど）enzymatic measures of cholestasis eg alkaline phosphatase 5 nucleotidase gamma glutamyl transpeptidase [show details]
…or 2 mol urea . Placental alkaline phosphatase and an isoenzyme found in certain cancers, the Regan isoenzyme, are fully heat-stable after exposure to a temperature of 56°C for 15 minutes . Thus, the finding …
2. ホスホグリセリン酸キナーゼ欠損症およびホスホグリセリン酸ムターゼ欠損症phosphoglycerate kinase deficiency and phosphoglycerate mutase deficiency [show details]
…Human PGAM is a dimer consisting of different amounts of muscle (MM) isozyme, brain (BB) isozyme, and the intermediate hybrid (MB) isozyme. Inheritance is autosomal recessive. Various distinct point mutations…
3. アスピリン：リウマチ性疾患における作用機序、主な毒性、および使用aspirin mechanism of action major toxicities and use in rheumatic diseases [show details]
…site of aspirin and nonsalicylate NSAID binding . Mammalian cells contain two related but unique isozymes of COX: PG endoperoxide H2 synthase-1 and -2 (COX-1 and COX-2, respectively). Both catalyze the …
4. グリコーゲン代謝のその他の障害：GLUT2欠損症およびアルドラーゼA欠損症other disorders of glycogen metabolism glut2 deficiency and aldolase a deficiency [show details]
…#611881) is a rare GSD associated with hereditary hemolytic anemia. In the glycolytic pathway, three isozymes of aldolase (A, B, and C) are responsible for the conversion of fructose-1,6-biphosphate into g …
5. 家族性アルドステロン症familial hyperaldosteronism [show details]
…the zona fasciculata. Two isozymes of 11-beta-hydroxylase encoded by two genes on chromosome 8 are responsible for the biosynthesis of aldosterone and cortisol : The isozyme in the zona glomerulosa (CYP11B2 …

English Journal

PMID 29083622

Regan isoenzyme of alkaline phosphatase as a tumour marker for renal cell carcinoma.

Bukowczan J, Pattman S, Jenkinson F, Quinton R.
Annals of clinical biochemistry. 2014 Sep;51(Pt 5)611-4.
Alkaline phosphatase is an enzyme present in all tissues of the human body. Several isoforms of this enzyme have been described with different catalytic nature, stability and antigenic structure. Rises in the activity of alkaline phosphatase are recognised in various states including bone diseases,
PMID 24615345

Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity.

Chen-Roetling J, Li Z, Regan RF.
Current neurovascular research. 2008 Aug;5(3)193-8.
The heme oxygenase (HO) enzymes catalyze the rate-limiting step of heme breakdown, and may accelerate oxidative injury to neurons exposed to heme or hemoglobin. HO-1 and HO-2 are activated in vitro by the phos-phatidylinositol 3-kinase (PI3K)/Akt and protein kinase C (PKC)/CK2 pathways, respectively
PMID 18691077

Japanese Journal

ニッポンバラタナゴの遺伝的変異性と亜種間交雑に関する研究

長田芳和,片山めぐみ,田部雅昭 [他],福原修一,加納義彦
大阪教育大学紀要 3 自然科学・応用科学 52(1), 29-40, 2003-09
八尾市内の溜池の1個体群と北九州佐賀県内の2河川および福岡県内の溜池の合計4個体群について, ニッポンバラタナゴの遺伝的差異を調べるためにアイソザイム分析を行った。北九州産では八尾市産より集団内の変異性が大きく, 地域による差異も認められた。北九州産のうち川に生息する個体群は八尾市溜池産との間に遺伝的差異が大きいのに対し, 溜池の個体群は八尾市産との間に遺伝的に類似性が高かった。地域による遺伝的差 …
NAID 110000561554

Cellular localization of alkaline phosphatase isozymes in three human cancer cell lines: Methodological considerations based on electron cytochemical studies.

MIYAYAMA HARUHIKO,TOKUMITSU SHINICHI,NOMURA HIROTSUNE,TAKEYA MOTOHIRO
Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 16(4), 415-430, 1983
… d Regan isozymes in HeLa S3-10 respectively.<BR>First, it is confirmed that the optimal conditions of the cell fixation, the substrate concentration and the cultured method, as factors which influenced on the electron cytochemical demonstration of alkaline phosphatase should be thoroughly studied cell-line to cell-line in order to accurately interpret the localization of each isozyme concerned.<BR>Second, it is shown that all of the enzyme activities of the early placental, Kasahara and Regan …
NAID 110003149111

Ultracytochemical localization of alkaline phosphatase isozymes in human cancer cell lines in vitro.

TAKEYA MOTOHIRO
Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 14(3), 223-235, 1981
… Biochemically identified cancer-associated alkaline phosphatase (orthophosphoric monoester phosphohydrolase, EC 3.1.3.1) isozymes were studied by electron microscopic cytochemistry in four human cancer cell lines, as follows: chorion isozyme in KMK-2, Regan isozyme in CaR-1 and HeLa S3-10, and Kasahara isozyme in HeLa S3-5. …
NAID 110003148778